Ask about this productRelated genes to: DCTD antibody
- Gene:
- DCTD NIH gene
- Name:
- dCMP deaminase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-10-02
- Date modifiied:
- 2014-11-19
Related products to: DCTD antibody
Related articles to: DCTD antibody
- : Nucleotide metabolism plays a critical role in cancer development, but the prognostic significance of genetic variants in nucleotide metabolism genes for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients remains unclear. : We performed Cox proportional hazards regression analyses to evaluate the association between genetic variants in 94 nucleotide metabolism-related genes and overall survival (OS) in 866 HBV-HCC patients. To assess the potential biological relevance of the identified variants, the Bayesian false discovery probability and false-positive report probability were applied for multiple testing correction. : Two independent SNPs, rs17074255 G>A (HR = 1.22, 95% CI: 1.06-1.40, = 0.005) and rs3763662 G>A (HR = 1.18, 95% CI: 1.03-1.34, = 0.015), were significantly associated with OS. A significant dose-dependent association between the number of risk genotypes and poorer OS was observed ( < 0.001). Luciferase reporter assays demonstrated allele-specific regulatory effects of rs3763662 on expression ( < 0.001). and mRNA expression levels were significantly elevated in HCC tumors in the UALCAN database and in our 103 paired samples. Higher expression levels of both genes were associated with poorer survival in the TCGA cohort ( = 0.003 and < 0.001). : Our findings suggest that rs3763662 (supported by direct functional evidence) and rs17074255 (supported by eQTL and expression associations) may serve as potential prognostic indicators for HBV-HCC through the regulation of mRNA expression. These findings provide new insights into the role of nucleotide metabolism-related genetic variation in HBV-HCC progression and may facilitate prognostic assessment, pending replication in independent cohorts. - Source: PubMed
Publication date: 2026/07/14
Mao YanLin QiulingLiu YingchunWei XiaoxiaZhou ZihanWen QiupingJiang YanjiChen PeiqinLiang XiumeiWei YuyingWei QingyiZhou WenjingYu Hongping - We introduce a novel automated well plate sampling system (AmbiSampler) using laser ablation-rapid evaporative ionization mass spectrometry (LA-REIMS) for label-free high-throughput biochemical screening for small volume biological fluid samples and cell line panels from multiwell plates. The human blood serum samples featured intensive signals in the low m/z range including fatty acids and metabolites and in the higher (m/z > 600) range associated with complex lipids, peptides, and proteins. We demonstrate the current quantification performance of the system through blood serum samples spiked with labelled amino acid mix. Cell line analysis was demonstrated by analyzing the NCI60 human cell lines panel grown in multiwell plates. Without any sample preparation, these experiments yielded rich metabolic and lipidomic mass spectrometry profiles, with classification results showing a 98.7% correct classification rate. We demonstrated that the new high-throughput setup using LA-REIMS technology provides an efficient and versatile approach for ambient ionization mass spectrometric analysis of various biological samples in a high-throughput manner. - Source: PubMed
Publication date: 2026/04/28
Horkovics-Kováts Gabriel SSimon DanielSchäffer RichárdPap IstvánNozari ZahraKönig AlexanderDecking-Paede SonjaSzand RolandMolnár AdriennSchlosser GittaKucsma NóraSzakács GergelyTakáts ZoltánBalog Júlia - - Source: PubMed
Publication date: 2026/04/28
Ettedgui JessicaBlackman BurchelleRaju NatarajanKotler Samuel AChekmenev Eduard YGoodson Boyd MMerkle HellmutWoodroofe Carolyn CLeClair Christopher AKrishna Murali CSwenson Rolf E - Dr. C. Norman Coleman's impact is difficult to measure overall, even if one focuses only on his work as NCI's Radiation Research Program (RRP) leader. His laboratory work spanned immune-oncology and radiation therapy, RNA biology, normal tissue and tumor tissue radiobiology, and the development of tissue chips for use in radiation biology research. His programmatic leadership helped the RRP develop health equity programs addressing Native American access to optimal cancer care, evaluation of hadron therapy biology, radiation biology, reproducibility and rigor, foundational molecular biology of the tumor and normal tissue caused by radiation therapy dynamically, and global health and security issues. While doing all these things, he found time to mentor countless people in the field, many now leaders, and to read and discuss science across disciplines. He was a dedicated, caring, kind scientist who truly wanted to help and improve the world for others. - Source: PubMed
Publication date: 2026/03/24
Aryankalayil Molykutty JPrasanna Pataji G SBuchsbaum Jeffrey C - - Source: PubMed
Publication date: 2026/01/29
Zhong YuanpingZhang ChaoLi YuanChen DongqinTang ChunchunZheng XueZhu Zhaoqiong