Ask about this productRelated genes to: PLSCR1 antibody
- Gene:
- PLSCR1 NIH gene
- Name:
- phospholipid scramblase 1
- Previous symbol:
- -
- Synonyms:
- MMTRA1B
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-08
- Date modifiied:
- 2016-10-05
Related products to: PLSCR1 antibody
Related articles to: PLSCR1 antibody
- We constructed a gene coexpression network to uncover central key genes related to Sjögren's disease (SjD), and investigated the clinical significance of bone marrow stromal antigen 2 (BST2) in SjD. - Source: PubMed
Publication date: 2026/04/09
Ren TianZhou XinZhou EryeLiu CuipingWu JianChang XinChen Weichang - Phosphatidylserine (PS) exposure on the surface of red blood cells (RBC) is a hallmark of membrane asymmetry loss and a prothrombotic signal often induced by oxidative stress and heavy metal toxicity. Mercury (Hg) is known to disrupt cellular redox balance and calcium homeostasis, leading to PS externalization and increased thrombotic risk. Natural antioxidants such as polyphenols may provide protection against these effects. The apple ( Mill. cv. ), a cultivar rich in procyanidins and phenolic compounds, has shown antioxidant and membrane-stabilizing properties. - Source: PubMed
Publication date: 2026/02/23
Perrone PasqualeMoriello ClaudiaAlessio NicolaContri AlbertoManna CaterinaD'Angelo Stefania - Liver fibrosis is a critical pathological stage in the progression of chronic liver diseases, yet safe and effective antifibrotic agents remain lacking. Anwulignan (Anwu), a lignan component derived from the traditional hepatoprotective herb Schisandra chinensis (Turcz.) Baill., possesses hepatoprotective properties; however, its antifibrotic potential and underlying mechanism remain undefined. - Source: PubMed
Publication date: 2026/02/06
Shang YuePeng Yan-GuiWang YanHuo Xiao-KuiZhang Hou-LiHao Tang-NaMa Xiao-Chi - Bluetongue virus (BTV) infects various ruminant species, posing significant threats to animal health and causing substantial economic losses to the livestock industry. Ovine type II alveolar epithelial cells (OAECIIs) play crucial roles in maintaining pulmonary structural integrity and modulating immune responses. Their dysfunction is closely associated with lung disease pathogenesis, making them important therapeutic targets. However, OAECIIs' immunoregulatory functions and early response mechanisms during BTV infection remain unclear. To address this, we analyzed transcriptomic changes in OAECIIs following BTV-1 infection. RNA-seq revealed 1047 and 852 differentially expressed genes (DEGs) at 8 and 12 h post-infection (hpi), respectively, compared to uninfected controls. Bioinformatics analysis showed significant upregulation of nucleic acid-sensing receptors, interferon-stimulating factors, inflammatory mediators, and cytokines during early infection, mediated primarily through type I interferon signaling, TNF signaling, and cytosolic DNA-sensing pathways. We identified MAD5, ZNFX1, cGAS, OAS, PKR and ZBP1 as key pattern recognition receptors in OAECIIs during BTV infection. The IFN-β, MX1/2, RSAD2 and PLSCR1 pathways mediated antiviral responses, while IL-15, CXCL10, CCL2 triggered inflammatory responses, collectively causing structural alterations through AQP1/9 and tight junction protein modulation. These findings provide critical insights into early antiviral mechanisms and cellular structural changes in OAECIIs during BTV infection, establishing a foundation for understanding pneumonia pathogenesis and developing targeted BTV therapies. - Source: PubMed
Publication date: 2026/01/13
Chen YunyiLei NijingYe ZhenghaoPu ShaohuaLuo ShimeiMa XianpingYang ShaoyuWang GuanghuaJia HuaijieYi Huashan - Efficient nuclear delivery of DNA remains a major challenge in non-viral gene therapy. While nuclear localization signal (NLS) peptides have been explored for enhancing nuclear translocation of DNA, their efficacy has been limited by DNA-peptide conjugation strategies. Leveraging E. coli tRNA guanine transglycosylase, we present a modular workflow for generating DNA oligonucleotide-peptide conjugates which are ligated to linear DNA to generate peptide-modified gene cassettes (DNA-PepTAG). Using an eGFP reporter delivered via lipofection to growth-arrested cells, NLS-modified gene cassettes significantly increases nuclear localization, mRNA transcription, and expression up to ~10 fold compared to unmodified gene cassettes. Screening multiple NLS peptides in growth-arrested human cell lines reveal cell-type-specific preferences for nuclear translocation of DNA cargo. Two NLS peptides, PLSCR-1 and extSV40, exhibit consistently high expression across tested cell types, indicating broad applicability for nuclear delivery. We evaluate the generality of our approach by delivering DNA payloads encoding for both cytosolic and secreted proteins, as well as gene cassettes ranging in size from 1.3 kbp to 7 kbp. These findings support the potential of DNA-NLS conjugates as a viable strategy for non-viral gene therapy, enabling enhanced nuclear delivery of therapeutic genes while minimizing the required DNA dose. - Source: PubMed
Publication date: 2026/01/07
Mohamedshah Zulfiqar YChi Chih-ChinTota Ember MKomor Alexis CDevaraj Neal K