Ask about this productRelated genes to: PLSCR1 antibody
- Gene:
- PLSCR1 NIH gene
- Name:
- phospholipid scramblase 1
- Previous symbol:
- -
- Synonyms:
- MMTRA1B
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-08
- Date modifiied:
- 2016-10-05
Related products to: PLSCR1 antibody
Related articles to: PLSCR1 antibody
- Triple-negative breast cancer (TNBC) frequently acquires chemoresistance, leading to poor clinical outcomes. Phospholipid scramblase 1 (PLSCR1) has been implicated in breast cancer progression, yet its precise role and underlying mechanisms in TNBC chemoresistance remain elusive. Here, we demonstrate that PLSCR1 is significantly upregulated in chemoresistant TNBC cell lines and patient samples. Mechanistically, PLSCR1 interacts with EGFR, promoting its phosphorylation and subsequent activation of the MAPK signaling pathway, which in turn upregulates the efflux pumps P-gp and MRP1. Concurrently, PLSCR1 mRNA undergoes METTL3-mediated m6A modification, which is recognized by the m6A reader IGF2BP3, leading to enhanced mRNA stability and translational efficiency. Functional studies revealed that PLSCR1 knockdown resensitizes resistant cells to epirubicin, whereas its overexpression exacerbates resistance both in vitro and in vivo. Clinically, elevated PLSCR1 expression correlates with reduced sensitivity to neoadjuvant chemotherapy and poorer prognosis in TNBC patients. Notably, Mogroside IV-A, a specific PLSCR1 inhibitor, effectively overcomes chemoresistance by disrupting PLSCR1-mediated EGFR activation. Collectively, our findings establish PLSCR1 as a critical node integrating the METTL3/IGF2BP3 epigenetic axis with EGFR-MAPK signaling to drive TNBC chemoresistance, and highlight PLSCR1 as a promising therapeutic target for combating drug resistance in TNBC. - Source: PubMed
Publication date: 2026/05/15
Lu YaoZeng XueliangPeng ShixiongZhan YangyangLiu WenyuZhao RuiLi JingHuang QiangYe TingtingYuan ZixuanHuang Panpan - We constructed a gene coexpression network to uncover central key genes related to Sjögren's disease (SjD), and investigated the clinical significance of bone marrow stromal antigen 2 (BST2) in SjD. - Source: PubMed
Publication date: 2026/04/09
Ren TianZhou XinZhou EryeLiu CuipingWu JianChang XinChen Weichang - Phosphatidylserine (PS) exposure on the surface of red blood cells (RBC) is a hallmark of membrane asymmetry loss and a prothrombotic signal often induced by oxidative stress and heavy metal toxicity. Mercury (Hg) is known to disrupt cellular redox balance and calcium homeostasis, leading to PS externalization and increased thrombotic risk. Natural antioxidants such as polyphenols may provide protection against these effects. The apple ( Mill. cv. ), a cultivar rich in procyanidins and phenolic compounds, has shown antioxidant and membrane-stabilizing properties. - Source: PubMed
Publication date: 2026/02/23
Perrone PasqualeMoriello ClaudiaAlessio NicolaContri AlbertoManna CaterinaD'Angelo Stefania - Liver fibrosis is a critical pathological stage in the progression of chronic liver diseases, yet safe and effective antifibrotic agents remain lacking. Anwulignan (Anwu), a lignan component derived from the traditional hepatoprotective herb Schisandra chinensis (Turcz.) Baill., possesses hepatoprotective properties; however, its antifibrotic potential and underlying mechanism remain undefined. - Source: PubMed
Publication date: 2026/02/06
Shang YuePeng Yan-GuiWang YanHuo Xiao-KuiZhang Hou-LiHao Tang-NaMa Xiao-Chi - Bluetongue virus (BTV) infects various ruminant species, posing significant threats to animal health and causing substantial economic losses to the livestock industry. Ovine type II alveolar epithelial cells (OAECIIs) play crucial roles in maintaining pulmonary structural integrity and modulating immune responses. Their dysfunction is closely associated with lung disease pathogenesis, making them important therapeutic targets. However, OAECIIs' immunoregulatory functions and early response mechanisms during BTV infection remain unclear. To address this, we analyzed transcriptomic changes in OAECIIs following BTV-1 infection. RNA-seq revealed 1047 and 852 differentially expressed genes (DEGs) at 8 and 12 h post-infection (hpi), respectively, compared to uninfected controls. Bioinformatics analysis showed significant upregulation of nucleic acid-sensing receptors, interferon-stimulating factors, inflammatory mediators, and cytokines during early infection, mediated primarily through type I interferon signaling, TNF signaling, and cytosolic DNA-sensing pathways. We identified MAD5, ZNFX1, cGAS, OAS, PKR and ZBP1 as key pattern recognition receptors in OAECIIs during BTV infection. The IFN-β, MX1/2, RSAD2 and PLSCR1 pathways mediated antiviral responses, while IL-15, CXCL10, CCL2 triggered inflammatory responses, collectively causing structural alterations through AQP1/9 and tight junction protein modulation. These findings provide critical insights into early antiviral mechanisms and cellular structural changes in OAECIIs during BTV infection, establishing a foundation for understanding pneumonia pathogenesis and developing targeted BTV therapies. - Source: PubMed
Publication date: 2026/01/13
Chen YunyiLei NijingYe ZhenghaoPu ShaohuaLuo ShimeiMa XianpingYang ShaoyuWang GuanghuaJia HuaijieYi Huashan