Ask about this productRelated genes to: PLA2G4E antibody
- Gene:
- PLA2G4E NIH gene
- Name:
- phospholipase A2 group IVE
- Previous symbol:
- -
- Synonyms:
- FLJ45651
- Chromosome:
- 15q15.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-04
- Date modifiied:
- 2015-11-18
Related products to: PLA2G4E antibody
Related articles to: PLA2G4E antibody
- The placenta shapes fetal brain development through metabolic and epigenetic regulation. The BTBR T Itpr3/J (BTBR) mouse provides a valuable model of neurodevelopmental vulnerability. This study investigates the cellular and spatial distribution of lipid metabolic and epigenetic alterations within the BTBR placenta. - Source: PubMed
Publication date: 2026/05/20
Viscomi Maria PiaZiętek Marta MarlenaWiniarczyk DawidSampino Silvestre - Hepatocellular carcinoma (HCC), the third leading cause of cancer mortality, is targeted by Lenvatinib-a multi-receptor tyrosine kinase (RTK) inhibitor suppressing VEGFR/FGFR signaling. This study explored whether lenvatinib modulates the tumor metabolic microenvironment to inhibit HCC progression. - Source: PubMed
Publication date: 2026/04/14
Zhao XiaofangYan ShengxiangMeng JingWang Limin - The phospholipase A (PLA) enzyme superfamily has been extensively studied, but comprehensive reviews on cytosolic phospholipase A group IVE (PLA2G4E) remain scarce, limiting our understanding of its role in lipid metabolism and disease. Our review synthesizes current findings on the human PLA2G4E gene and its murine ortholog Pla2g4e, drawing from multi-omics analyses and a range of functional studies. Pla2g4e exhibits distinct expression patterns across tissues, suggesting potential tissue-specific roles. In addition to its phospholipase activity, PLA2G4E exhibits N-acyltransferase activity and responds to calcium influx. Emerging evidence suggests possible involvement in metabolic disorders such as obesity and diabetes, particularly through effects on glucose uptake and insulin sensitivity. PLA2G4E has been implicated in the synthesis of N-acylethanolamines with potential effects on energy homeostasis, stress adaptation, neuronal signaling, pain perception, cognition, and motor coordination. Genomic and preliminary functional evidence further point to possible roles in immune regulation and neurobiology, with some associations reported in neurodegenerative diseases such as Alzheimer's disease. Comprehensive insights into the biological roles of PLA2G4E are essential for clarifying its enzymatic functions and potential involvement in disease mechanisms; however, further experimental and clinical studies are needed to substantiate these emerging associations and assess its therapeutic potential. - Source: PubMed
Publication date: 2025/11/11
Čater MašaŠimon MartinMorton Nicholas MKunej TanjaHorvat Simon - Sepsis is a leading global health burden in children, and its unavoidable heterogeneity has hindered providing therapies beyond antibiotics and supportive care. Recently, we identified four computable phenotypes showing distinct cytokine profiles, clinical outcomes, and therapeutic response characteristics (PedSep-A, B, C, and D) in a multicenter pediatric sepsis cohort. - Source: PubMed
Publication date: 2025/10/11
Qin YidiKernan Kate FBai YulongShaffer John RUrban ZsoltCanna ScottPollack Murray MMeert KathleenNewth ChristopherShanley TomHarrison Rick EHall MarkCarcillo Joseph APark Hyun-Jung - Chronic obstructive pulmonary disease (COPD) causes significant morbidity and mortality, ranking as the third leading cause of death globally. Cordyceps sinensis (C. sinensis), has long been used in Asia as a tonic of traditional Chinese medicine, to alleviate lung ailments, and exhibits a potential therapeutic effect on COPD. This study aimed to explore the protective effects of C. sinensis on COPD and elucidate the underlying molecular mechanism. In this study, COPD was induced in rats via cigarette smoke exposure combined with intratracheal lipopolysaccharide (LPS) administration, followed by C. sinensis treatment. Pathological alterations in lung tissue and inflammatory cytokines in serum and lung tissue were assessed, and an integrated analysis combining proteomics, metabolomics, serum pharmacochemistry, network pharmacology, and molecular biology was conducted. The result showed that C. sinensis treatment significantly alleviated lung tissue injury in COPD rats, with the medium dose exhibiting particularly notable efficacy. Furthermore, C. sinensis administration reduced the levels of inflammatory factors (TNF-α, IL-8, MMP-9) in serum and lung tissue, suggesting a potential anti-inflammatory role in COPD. Integrated metabolomics and proteomics analysis revealed that the protective effect of C. sinensis against COPD critically depended on regulating glycerophospholipid and sphingolipid metabolism by targeting PLA2G4E and B4GALT4 proteins, which confirmed by WB and qRT-PCR. The analysis of serum samples identified 20 blood-entering compounds from C. sinensis. Network pharmacology analysis revealed that sphingolipid components in C. sinensis exert therapeutic effects against COPD through multi-target interactions, primarily involving AKT1, ESR1, TLR4, and MMP9. The findings further revealed that C. sinensis mainly modulated COPD through the PI3K-AKT signaling pathway. Additionally, WB experiments verified that C. sinensis reversed p-AKT in the lung tissue of COPD rats. In conclusion, C. sinensis may influence the PI3K-AKT signaling pathway in COPD rats, potentially affecting glycerophospholipid metabolism and sphingolipid metabolism by targeting PLA2G4E and B4GALT4 proteins, thereby alleviating the inflammatory response and mitigating lung tissue damage caused by COPD. - Source: PubMed
Publication date: 2025/07/22
Zhou WenbinLiu YingyingGao YaqiSuonanlamao Ma YuananXiao YuancanWei Lixin