Ask about this productRelated genes to: COPG2 antibody
- Gene:
- COPG2 NIH gene
- Name:
- coatomer protein complex subunit gamma 2
- Previous symbol:
- -
- Synonyms:
- 2-COP
- Chromosome:
- 7q32.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-17
- Date modifiied:
- 2016-10-05
- Gene:
- COPG2IT1 NIH gene
- Name:
- COPG2 imprinted transcript 1
- Previous symbol:
- -
- Synonyms:
- CIT1, NCRNA00170, COPG2AS
- Chromosome:
- 7q32
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2000-05-19
- Date modifiied:
- 2018-05-16
Related products to: COPG2 antibody
Related articles to: COPG2 antibody
- MEST is one of the imprinted genes in human. With the assistance of our integration map and the complete sequence in the registry, we mapped a total of 16 genes/transcripts at the 1.5-Mb MEST-flanking region at 7q32. This region has been suggested to form an imprinted gene cluster, because MEST and its three flanking genes/transcripts (MESTIT1, CPA4, and COPG2IT1) were reported to be imprinted, although two (TSGA14 and COPG2) were shown to escape imprinting. In this study, 10 other genes/transcripts were examined for their imprinting status in human fetal tissues. The results indicated that 8 genes/transcripts (NRF1, UBE2H, HSPC216, KIAA0265, FLJ14803, CPA2, CPA1, and DKFZp667F0312) were expressed biallelically. The imprinting status of two (TSGA13 and CPA5) was not conclusive, because of their weak and/or tissue-specific expression and inconstant results. These findings provided evidence that only 4 of the 16 genes/transcripts located to the region show monoallelic expression, while others are not involved in imprinting. Therefore, it is less likely that the MEST-flanking 7q32 region forms a large imprinted domain. - Source: PubMed
Yamada TakahiroMitsuya KohzohKayashima TomohikoYamasaki KentaroOhta TohruYoshiura Koh-ichiroMatsumoto NaomichiYamada HidetoMinakami HisanoriOshimura MitsuoNiikawa NorioKishino Tatsuya - We identified the gene TSGA14, encoding the testis-specific protein A14 and located 50 kb proximal to the imprinted gene MEST in a head-to-head orientation. TSGA14 has at least two transcripts: a long-type (l-type) transcript, and a short-type (s-type) transcript. Since the COPG2IT1 gene in the vicinity of MEST has been reported to be imprinted, we presumed that TSGA14 might also be imprinted. We thus analyzed the imprinting status of TSGA14 l-type and s-type transcripts in various fetal tissues. TSGA14 l-type transcript, which consists of 11 exons and encodes a l-type isoform with 373 amino acids, is biallelically expressed in the fetal tissues including the testis. TSGA14 s-type transcript, which consists of three exons and encodes a s-type isoform with 54 amino acids, also showed biallelic expression in the fetal brain and liver. No allele-specific methylation in the TSGA14 CpG island was detected. The fact that COPG2 and TSGA14, both neighbors of MEST, escape genomic imprinting suggests that the 7q32 imprinted region may be small and not similar to other imprinted domains, such as those at 15q11-13 and 11p15.5. - Source: PubMed
Yamada TakahiroKayashima TomohikoYamasaki KentaroOhta TohruYoshiura Koh ichiroMatsumoto NaomichiFujimoto SeiichiroNiikawa NorioKishino Tatsuya