Ask about this productRelated genes to: VPS52 antibody
- Gene:
- VPS52 NIH gene
- Name:
- VPS52 subunit of GARP complex
- Previous symbol:
- SACM2L
- Synonyms:
- ARE1
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-25
- Date modifiied:
- 2019-01-25
Related products to: VPS52 antibody
Related articles to: VPS52 antibody
- Pathogen and pest effectors play a crucial role in manipulating plant biological processes, facilitating infection and infestation. While pathogens and pests secrete repertoires of effectors into host plants, most effector function studies focus on characterising individual proteins. Our previous work identified a genetically linked and co-regulated gene pair in the aphid pest Myzus persicae encoding effectors Mp1 and Mp58. Here, we explored the functional link between these two effectors. We revealed that effectors Mp1 and Mp58 interact in planta and in vitro and form an oligomeric complex. The putative orthologs of the Mp1-Mp58 pair in the aphid species Rhopalosiphum padi, Rp1 and Rp58 also interact, but members of the pair cannot interact across aphid species, suggesting that effector pairs have co-evolved within each aphid species but diversified across species. Both Mp1 and Mp58 associate with the host Vacuolar Protein Sorting associated Protein 52 (VPS52) to form an Mp1-Mp58-VPS52 complex which localises at vesicle-like structures. Our findings point to effector complex formation in plant-insect interactions and highlight a further layer of complexity in the molecular dialogue between insects and their host plants. Our work highlights the importance of considering the context in which effectors may function within a larger effector repertoire. - Source: PubMed
Publication date: 2026/02/21
Bleau Jade RGaur NamamiFisher S RonanWaksman ThomasPorter MichaelBos Jorunn I B - To construct a diagnostic model of osteoarthritis related to methylation genes using machine learning algorithms, and analyze its prognostic value and biological functions. - Source: PubMed
Publication date: 2025/08/01
Cui XuJi HoulinGuo ShengyangLiu JuZhang LinyuanJia YongweiCui YinZhou Xiaoxiao - This study aim to leverage advanced machine learning techniques to develop and validate novel MRI imaging features and single nucleotide polymorphism (SNP) gene data fusion methodologies to enhance the early identification and diagnosis of Parkinson's disease (PD). - Source: PubMed
Publication date: 2025/02/04
Yang YifengHu LiangyunChen YangGu WeidongLin GuangwuXie YuanZhongNie Shengdong - Homozygous variants have been previously described in two unrelated patients with a neurodevelopmental disorder with microcephaly, seizures and neonatal cholestasis. encodes a subunit that is unique to the heterotetrameric endosome-associated recycling protein (EARP) complex. The other subunits of the EARP complex, such as VPS51, VPS52 and VPS53, are also shared by the Golgi-associated retrograde protein complex. We report on an 18-month-old female patient with biallelic variants. She carried a paternally inherited heterozygous nonsense c.13A>T; p.(Lys5*) variant. By long-read genome sequencing, we characterised a structural variant with a 4.3 Mb inversion flanked by deletions at both breakpoints on the maternal allele. The ~428 kb deletion at the telomeric inversion breakpoint encompasses the entire gene. We demonstrated a deficiency of VPS50 in patient-derived fibroblasts, confirming the loss-of-function nature of both variants. VPS53 and VPS52 protein levels were significantly reduced and absent, respectively, in fibroblasts of the patient. These data show that VPS50 and/or EARP deficiency and the associated functional defects underlie the phenotype in patients with pathogenic variants. The -related core phenotype comprises severe developmental delay, postnatal microcephaly, hypoplastic corpus callosum, neonatal low gamma-glutamyl transpeptidase cholestasis and failure to thrive. The disease is potentially fatal in early childhood. - Source: PubMed
Publication date: 2024/08/29
Hecher LauraGorski-Alberts EstherBegemann MatthiasHerwig JohannaLausberg EvaHillebrand GeorgVolk Alexander EKurth IngoKraft FlorianKutsche Kerstin - The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network. The tethering step requires several complexes, including the Golgi-associated retrograde protein complex, whose localization at the trans-Golgi network is determined by the activity of small GTPases of the Arl and Rab family. However, how the Golgi-associated retrograde protein complex recognizes the endosome-derived carriers that will fuse with the trans-Golgi network is still unknown. - Source: PubMed
Publication date: 2024/04/16
Gilleron JérômeChafik AbderrahmanLacas-Gervais SandraTanti Jean-FrançoisCormont Mireille