Ask about this productRelated genes to: SLC12A1 antibody
- Gene:
- SLC12A1 NIH gene
- Name:
- solute carrier family 12 member 1
- Previous symbol:
- -
- Synonyms:
- NKCC2
- Chromosome:
- 15q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-02-16
- Date modifiied:
- 2016-02-17
Related products to: SLC12A1 antibody
Related articles to: SLC12A1 antibody
- Whiplash-associated disorder grade II (WADII) is characterised by persistent pain in the absence of frank nerve injury, yet its molecular mechanisms remain unclear. - Source: PubMed
Publication date: 2026/07/31
Fundaun JoelRidehalgh ColetteDilley AndrewSchmid Annina BBaskozos Georgios - Environmental salinity instability associated with climate change increasingly challenges aquatic organisms inhabiting marine and estuarine ecosystems. Although osmotic acclimation mechanisms in euryhaline fish have been extensively investigated, whether ancestral osmotic stress exposure alters offspring osmotic responsiveness remains poorly understood. In the present study, marine medaka (Oryzias melastigma) derived from osmotic stress-experienced (EXP) and non-experienced (Non-Exp) F2 lineages were subjected to acute hypotonic challenge before gill RNA-sequencing analysis. Acute hypotonic exposure induced broader transcriptomic remodeling in the Non-Exp lineage, whereas the Exp lineage exhibited a smaller but more condensed enrichment profile associated with osmosensing- and ion transport-related pathways. The Non-Exp lineage predominantly enriched pathways related to RNA transcription, membrane trafficking, epithelial remodeling, and stress-associated signaling. In contrast, the Exp lineage preferentially enriched pathways associated with TRP channels, stimuli-sensing channels, ion channel transport, and SLC-mediated transmembrane transport. Representative osmoregulatory transcripts including trpv4, aqp3, and slc12a1 were additionally altered in the Exp lineage. Collectively, these findings suggest that ancestral osmotic stress exposure may influence offspring transcriptomic responses to acute hypotonic challenge and provide evidence for transgenerational plasticity in osmotic acclimation. - Source: PubMed
Publication date: 2026/07/16
Lai Keng PoQin XianChan Sidney Man NgaiWong Emily Sze WanQin JingruTse William Ka Fai - Longstanding observational work has associated Nonalcoholic Fatty Liver Disease (NAFLD) with hypertension and suggested that antihypertensive therapy may slow NAFLD progression. However, confounding and reverse causation in these studies obscure the effects on the risk for NAFLD. To tackle this problem, the study utilized Mendelian randomization (MR) to test the causal antihypertensive effects of drug targets on NAFLD and to evaluate safety. - Source: PubMed
Publication date: 2026/06/24
Zhang KanglongGuo LingGan YimingChen YihuaJiang ZhiweiYu ShuqinLei QiaoRan LinweiZheng JieHu Guoxin - Bartter syndrome (BS) is a general term for a group of rare genetic disorders in which the defective kidneys have impaired ability to reabsorb salt, resulting in salt wasting, hypokalemia, and metabolic alkalosis. Prenatal diagnosis of antenatal BS is challenging because of the absence of structural anomalies in the fetus. We here report four cases of antenatal BS identified in utero by fetal exome analysis. - Source: PubMed
Chen Gui-LanLi Dong-Zhi - This study employs network toxicology to screen for toxicological targets of cadmium chloride-induced male infertility, and validates the mechanism of Yishen Tongluo Formula in treating cadmium-induced male infertility through animal experiments. - Source: PubMed
Publication date: 2026/06/04
Hu JingWang YifeiMa SichengLiu HengZhang YinuoYu WenlinGao YizheLu JunZhang Chenming