Ask about this productRelated genes to: GFOD1 antibody
- Gene:
- GFOD1 NIH gene
- Name:
- glucose-fructose oxidoreductase domain containing 1
- Previous symbol:
- C6orf114
- Synonyms:
- FLJ20330, ADG-90
- Chromosome:
- 6p24.1-p23
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-19
- Date modifiied:
- 2018-02-13
Related products to: GFOD1 antibody
Related articles to: GFOD1 antibody
- Lumpy Skin Disease (LSD) is a transboundary viral disease of cattle associated with substantial economic losses. During an LSD outbreak at ICAR-National Dairy Research Institute, Sahiwal cattle maintained at the institute and vaccinated with a live attenuated goatpox vaccine exhibited considerable variation in disease response. Based on clinical presentation, animals were classified into clinically affected (G1) and clinically non-affected (G2) groups. This study represents a preliminary investigation aimed at exploring genomic variants associated with differential disease response. Whole-genome sequencing was performed to identify variants linked to clinical outcome.Genome-wide allelic association analysis identified 160 single nucleotide polymorphisms (SNPs) representing putative SNPs differentiating the two groups. clinically affected animals, SNPs rs30477737 and rs26324422 mapped to regions containing ZSCAN26 and PGBD1, respectively, whereas in clinically non-affected animals, SNP rs43160202 was located near PHACTR1, GFOD1, TBC1D7, and SIRT5. These genes are implicated in transcriptional regulation, intracellular signaling, metabolic processes, and cellular stress responses. The identified genomic regions provide a foundation for future functional validation and may contribute to a better understanding of the genetic mechanisms underlying variation in host immune response to LSD in cattle. - Source: PubMed
Publication date: 2026/08/15
Misal SnehalPatil AkshataChhotaray SupriyaAlex RaniGandham Ravi KumarVohra Vikas - Ischemic cardiomyopathy (ICM) is a condition characterized by inadequate blood supply to the coronary arteries, resulting in myocardial damage and decreased cardiac functionality. This study aimed to identify potential biomarkers and regulatory networks in ICM, providing a foundation for further mechanistic and therapeutic investigations. - Source: PubMed
Publication date: 2026/07/29
Ye XianhuaWu GuoxiangXie JialanWu YanqingChen DaqiuChen YixingXu ShanghuaLuo Shunxiang - Investigating the genetic attributes of indigenous goat breeds is crucial for their conservation and breeding. The Matou goat, a valued native breed of Southern China, is characterized by high meat quality and reproductive efficiency, representing an important genetic resource for livestock production. Its genetic basis underlying productive traits remains unclear at the whole-genome level. Therefore, this study aimed to elucidate its genomic diversity and selection signatures with whole-genome sequencing (WGS), in order to provide a basis for its future conservation and breeding. Population structure analyses, including principal component analysis, phylogenetic tree construction, and admixture analysis, revealed that the 128 sampled individuals could be divided into two subgroups. One subgroup exhibited greater genetic diversity, as reflected by higher heterozygosity and lower inbreeding coefficients, along with a higher frequency of private alleles indicative of a more closed breeding history. The slower linkage disequilibrium decay observed in this subgroup suggests it has undergone stronger selection. By integrating Fst, XP‑CLR, and XP‑EHH analyses, we identified 215 genes within 306 candidate regions under selection. Several of these genes (ARHGAP31, CHURC1, ITGA11, and GFOD1) harbor variants that overlap with QTLs and are associated with production traits in livestock. These findings provide a basis for conservation and breeding of the Matou goat. - Source: PubMed
Cheng LeiYu JieChen HongboXiang MinYang WujunWang ChenyanYan RubingDeng TingxianLiu Chenhui - Acute and chronic high-temperature stress negatively impact olive flounder (Paralichthys olivaceus) aquaculture, weakening immune function and increasing mortality. This study conducted a genome-wide association study (GWAS) to identify genetic markers linked to thermal stress resilience. A total of 384 fish were exposed to acute stress (29 °C for 30 min and 1 h) and chronic stress (19.8-30 °C for 16 days). Genomic DNA from 329 deceased and 55 surviving fish was genotyped using a 70 K SNP chip, yielding 57,638 SNPs from 376 fish after quality filtering. GWAS identified 34 SNPs associated with both acute and chronic thermal stress on chromosomes 4, 10, 11, 15, 18, 19, and 23, surpassing the suggestive (p < 1 × 10) and Bonferroni-corrected (p < 8.6 × 10) thresholds. Genes myhc, nlrc5, hydin, and gfod1 were linked to thermal stress. These findings may support marker-assisted selection for thermal stress resilience strains, promoting sustainable aquaculture. - Source: PubMed
Publication date: 2025/09/30
Hanchapola H A C RGong PoKim GaeunLiyanage D SOmeka W K MKim JeongeunKodagoda Yasara KavindiDilshan M A HRodrigo D C GGanepola G A N PiyumikaMassault CecileJerry Dean RLee JihunLee Jehee - The potential of inhibiting hsa-miR-19b-3p as a therapeutic approach for triple-negative breast cancer (TNBC) was investigated. To explore this, we studied the function of hsa-miR-19b-3p in TNBC cells, specifically the MDA-MB-231 cell line. We transfected these cells with LNA-anti-miR to inhibit the miRNA and then used qRT-PCR to measure the level of inhibition. Interestingly, we observed over 95 % inhibition at 24 h, and even at 48 h, the inhibition remained high at over 75 %. Upon closer examination, we determined the impact of this inhibition on cell viability using MTT assays, which showed a significant decrease in cell numbers following treatment with LNA-anti-miR-19b-3p. Furthermore, our apoptosis analysis, using Annexin V/Propidium iodide staining, revealed an increased apoptosis rate in the transfected cells compared to the controls. Alongside these experimental studies, we employed computational methods to investigate hsa-miR-19b-3p in greater detail, including RNA-Seq analysis of TCGA data, which identified 2585 upregulated and 4251 downregulated genes. Cross-referencing downregulated genes with target genes from miRTarBase, RNAInter, and miRWalk led to the identification of four potential hsa-miR-19b-3p targets: TMTC1, MBNL3, FAT3, and GFOD1, with TMTC1 and MBNL3 showing statistically significant downregulation. Additionally, we screened for potential small molecule inhibitors, identifying four promising candidates, including Dovitinib, S-Adenosylmethionine, Guanosine-5',3'-tetraphosphate, and Neomycin, which exhibited favorable drug-like characteristics. In conclusion, our multifaceted approach demonstrates the significant potential of LNA-anti-miR-19b-3p as a therapeutic option for TNBC patients, and the small molecule inhibitors we've uncovered could open new avenues for treating this aggressive form of breast cancer. - Source: PubMed
Publication date: 2025/07/14
Kamali Mohammad JavadSaeedi FatemehKhoshghiafeh AzinMir Mahsa AghajaniAram CenaAhmadifard Mohamadreza