Ask about this productRelated genes to: CDRT4 antibody
- Gene:
- CDRT4 NIH gene
- Name:
- CMT1A duplicated region transcript 4
- Previous symbol:
- -
- Synonyms:
- FLJ36674
- Chromosome:
- 17p12
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-01
- Date modifiied:
- 2015-08-24
- Gene:
- TVP23C-CDRT4 NIH gene
- Name:
- TVP23C-CDRT4 readthrough
- Previous symbol:
- FAM18B2-CDRT4
- Synonyms:
- -
- Chromosome:
- 17p12
- Locus Type:
- readthrough
- Date approved:
- 2011-09-28
- Date modifiied:
- 2012-11-29
Related products to: CDRT4 antibody
Related articles to: CDRT4 antibody
- One of the major factors inducing senescence is reactive oxygen species (ROS) produced from dysfunctional mitochondria. Therapeutic strategies that reduce mitochondrial ROS generation are considered essential for rejuvenating senescence, but effective methods have not yet been established. Here, we screened phenylpropanoids (PPs), secondary metabolites produced in response to oxidative stress in plants, and identified dehydroacteoside as a potential candidate. Dehydroacteoside restored mitochondrial function, thereby reducing mitochondrial ROS generated by inefficient electron transport. Furthermore, senescence-associated phenotypes were restored by dehydroacteoside-mediated ROS reduction. Using RNA sequencing, we identified TVP23C-CDRT4 as a gene that plays a critical role in dehydroacteoside-mediated senescence rejuvenation. Knockdown of TVP23C-CDRT4 showed similar effects to dehydroacteoside, reducing ROS and subsequently restoring senescence-associated phenotypes. Taken together, our study uncovered a novel mechanism by which dehydroacteoside reduces mitochondrial ROS generation, thereby restoring senescence. Our findings open the way to a new field of anti-aging therapy aimed at controlling senescence by modulating ROS production in mitochondria. - Source: PubMed
Publication date: 2025/06/03
Lee Yoo JinSong Eun SeonLee Yun HaengLee Kyeong SeonSo ByeonghyeonPark Ji HoYoon Jee HeeKim DuyeolKim MinseonKwon Hyung WookByun YoungjooLee Ki YongPark Joon Tae - Phase-separated membraneless organelles often contain RNAs that exhibit unusual semi-extractability using the conventional RNA extraction method, and can be efficiently retrieved by needle shearing or heating during RNA extraction. Semi-extractable RNAs are promising resources for understanding RNA-centric phase separation. However, limited assessments have been performed to systematically identify and characterize semi-extractable RNAs. In this study, 1074 semi-extractable RNAs, including ASAP1, DANT2, EXT1, FTX, IGF1R, LIMS1, NEAT1, PHF21A, PVT1, SCMH1, STRG.3024.1, TBL1X, TCF7L2, TVP23C-CDRT4, UBE2E2, ZCCHC7, ZFAND3 and ZSWIM6, which exhibited consistent semi-extractability were identified across five human cell lines. By integrating publicly available datasets, we found that semi-extractable RNAs tend to be distributed in the nuclear compartments but are dissociated from the chromatin. Long and repeat-containing semi-extractable RNAs act as hubs to provide global RNA-RNA interactions. Semi-extractable RNAs were divided into four groups based on their k-mer content. The NEAT1 group preferred to interact with paraspeckle proteins, such as FUS and NONO, implying that RNAs in this group are potential candidates of architectural RNAs that constitute nuclear bodies. - Source: PubMed
Zeng ChaoChujo TakeshiHirose TetsuroHamada Michiaki - The aim of this study was to investigate the underlying mechanisms of adenoid cystic carcinoma (ACC) at the transcriptome level. We obtained paired tumor and normal salivary gland tissues from 15 ACC patients, which were prepared for RNA sequencing. Gene enrichment analysis revealed that the upregulated pathways were mainly involved in axonogenesis, and the downregulated pathways were mainly related to leukocyte migration, the adaptive immune response, lymphocyte-mediated immunity, and the humoral immune response. T-cells, B-cells and NK cells showed low infiltration in ACC tissues. In addition to the gene fusions MYB-NFIB and MYBL1-NFIB, a new gene fusion, TVP23C-CDRT4, was also detected in 3 ACC tissues. PRAME was significantly upregulated in ACC tissues, while antigen-presenting human leukocyte antigen (HLA) genes were downregulated. We found a new gene fusion, TVP23C-CDRT4, that was highly expressed in ACC. PRAME may be an attractive target for ACC immunotherapy. - Source: PubMed
Publication date: 2023/04/21
Tang Yu-FangAn Pu-GenGu Bao-XinYi ShuHu XiaoWu Wen-JieZhang Jie