Ask about this productRelated genes to: FLJ33790 antibody
- Gene:
- KLHL35 NIH gene
- Name:
- kelch like family member 35
- Previous symbol:
- -
- Synonyms:
- FLJ33790
- Chromosome:
- 11q13.4
- Locus Type:
- gene with protein product
- Date approved:
- 2008-07-07
- Date modifiied:
- 2016-04-25
Related products to: FLJ33790 antibody
Related articles to: FLJ33790 antibody
- This study investigates the expression patterns and clinical relevance of KLHL35 (Kelch-Like Family Member 35) across various cancer types, with a focus on colorectal cancer. Comprehensive analysis of RNA sequencing data from The Cancer Genome Atlas (TCGA) and protein expression data from the Human Protein Atlas (HPA) revealed significant overexpression of KLHL35 in 13 tumor types, including colorectal cancer. Increased KLHL35 expression was associated with poor clinical outcomes, including overall survival (OS), progression-free interval (PFI), and disease-specific survival (DSS). Receiver operating characteristic (ROC) curve analysis suggested promising but exploratory diagnostic value for KLHL35, with area under the curve (AUC) values exceeding 0.9 in colorectal cancer. Functional enrichment analyses suggested potential associations between KLHL35 and cell cycle/apoptosis pathways, while immune infiltration correlations hinted at a possible role in immune microenvironment remodeling. In vitro assays confirmed KLHL35’s role in promoting cancer cell proliferation, invasion, and migration. These findings suggest that KLHL35 could serve as a valuable diagnostic and prognostic biomarker and a potential therapeutic target, particularly in colorectal cancer. While these findings nominate KLHL35 as a candidate for therapeutic targeting, further mechanistic studies are required to validate its function.” - Source: PubMed
Publication date: 2025/10/20
Qin RongDuan YiyaoBao ShashaWang HuiZhou JingFan XiruiLi XiangLi GuoyuHu Jun - - Source: PubMed
Publication date: 2025/10/09
Ye JiayouZhang TingtingWang GuangshengBian GuofengChen AijunZhou Xin - Colorectal cancer (CRC) ranks among the frequently occurring malignant neoplasms affecting the gastrointestinal tract. This study aimed to explore JAK-STAT signaling pathway related genes in CRC and establish a new prognostic model. - Source: PubMed
Publication date: 2025/02/07
Zhang NanYue WenliJiao BihangCheng DuoWang JingjingLiang FangWang YingnanLiang XiyueLi KunkunLiu JunweiLi Yadong - Human identical twins are born at a rate of 3-4 per 1000 live births. Many other mammals also occasionally produce monozygotic twins, referred to as sporadic polyembryony. The underlying mechanisms are unknown. Through epigenome-wide association studies (EWAS), we identified a robust DNA methylation signature in somatic tissues from human monozygotic (MZ) twins, comprising 834 differentially methylated positions (MZ-DMPs). The results point to a connection between monozygotic twinning and early genome programming and enable new angles to study monozygotic twinning. - Source: PubMed
Publication date: 2024/10/06
van Dongen JennyBreeze Charles ETwinning Genetics Consortium - Necroptosis, a programmed cell death pathway, has been demonstrated to be activated in Alzheimer's disease (AD). However, the precise role of necroptosis and its correlation with immune cell infiltration in AD remains unclear. In this study, we conducted non-negative matrix factorization clustering analysis to identify three subtypes of AD based on necroptosis-relevant genes. Notably, these subtypes exhibited varying necroptosis scores, clinical characteristics and immune infiltration signatures. Cluster B, characterized by high necroptosis scores, showed higher immune cell infiltration and was associated with a more severe pathology, potentially representing a high-risk subgroup. To identify potential biomarkers for AD within cluster B, we employed two machine learning algorithms: the least absolute shrinkage and selection operator regression and Random Forest. Subsequently, we identified eight feature genes (CARTPT, KLHL35, NRN1, NT5DC3, PCYOX1L, RHOQ, SLC6A12, and SLC38A2) that were utilized to develop a diagnosis model with remarkable predictive capacity for AD. Moreover, we conducted validation using bulk RNA-seq, single-nucleus RNA-seq, and in vivo experiments to confirm the expression of these feature genes. In summary, our study identified a novel necroptosis-related subtype of AD and eight diagnostic biomarkers, explored the roles of necroptosis in AD progression and shed new light for the clinical diagnosis and treatment of this disease. - Source: PubMed
Publication date: 2024/03/13
Lian PiaopiaoCai XingYang XiaomanMa ZhuoranWang CailinLiu KeWu YiCao XuebingXu Yan