Ask about this productRelated genes to: TTC33 antibody
- Gene:
- TTC33 NIH gene
- Name:
- tetratricopeptide repeat domain 33
- Previous symbol:
- -
- Synonyms:
- OSRF
- Chromosome:
- 5p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-24
- Date modifiied:
- 2014-11-19
Related products to: TTC33 antibody
Related articles to: TTC33 antibody
- The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners using comparative label-free mass spectrometry. The TTC33-associated network (TAN) comprises WDR61, CCDC97, UNG1/2, PP2A-B55α, PHF5A, and components of the SF3B U2 spliceosomal complex. Using a combination of biochemical assays, structural modeling and molecular dynamics we show that TTC33 directly recruits WDR61 and PHF5A to assemble into a trimeric core complex (TANC), which then forms distinct interactions with either UNG1/2 or SF3B-CCDC97. Somatic TTC33 mutations at key TANC interface residues reduce complex stability and weaken the interaction network. We further show that WDR61 stabilizes TTC33 by protecting it from proteolytic degradation. Loss of network components induces genomic instability and activates DNA damage markers, including γH2AX and p53 phosphorylation. - Source: PubMed
Publication date: 2026/08/21
Tomecki RafałDrabko MałgorzataSiek MałgorzataMatykiewicz MariaLudwinek MiłoszBorowski Łukasz SJurkiewicz AnetaKobyłecki KamilJabłońska AgnieszkaCysewski DominikMalinowska AgataBakun MagdalenaPłoski RafałSzczęsny Roman JTudek Agnieszka - Clinical and epidemiological evidence has suggested a potential association between kidney dysfunction and bladder cancer (BC). One hypothesis for this comorbidity is the presence of a common genetic etiology. However, little is known about the shared genetics and causality of this association. Thus, we aimed to investigate shared genetic architecture and the causal link between kidney dysfunction and bladder cancer. - Source: PubMed
Lin YifeiXiang NanyanYang YongHuang ShujunSu ShiqiFu TingtingLuo YuruiWang ZengShi RuiZheng TaoLiao BanghuaHuang Jin - For this study, we investigated comprehensive expression of conjoined genes (CGs) in non-Hodgkin B-cell lymphoma (B-NHL) cell line KPUM-UH1 by using paired-end RNA sequencing. Furthermore, we analyzed the expression of these transcripts in an additional 21 cell lines, 37 primary samples of various malignancies and peripheral blood mononuclear cells of four normal individuals. Seventeen CGs were detected in KPUM-UH1: CTBS-GNG5, SRP9-EPHX1, RMND5A-ANAPC, OTX1-EHBP1, ATF2-CHN1, PRKAA1-TTC33, LARP1-MRPL22, LOC105379697-BAK1, TIAM2-SCAF8, SPAG1-VPS13B, WBP1L-CNNM2, NARS2-GAB2, CTSC-RAB38, VAMP1-CD27-AS1, LRRC37A2-NSF, UBA2-WTIP and ZNF600-ZNF611. To our knowledge, 10 of these genes have not been previously reported. The various characteristics of the CGs included in- and out-of-frame fusions, chimeras involving non-coding RNA and transcript variants. A finding of note was that LARP1-MRPL2 was characterized as in-frame fusion and was recurrently expressed in B-NHL samples. In this study, variety of CGs was expressed both in malignant and normal cells, some of which might be specific to lymphoma. - Source: PubMed
Publication date: 2021/04/20
Matsumoto YosukeTsukamoto TakuChinen YoshiakiShimura YujiSasaki NanaNagoshi HisaoSato RyuichiAdachi HirokoNakano MasakazuHoriike ShigeoKuroda JunyaTaki TomohikoTashiro KeiTaniwaki Masafumi