Ask about this productRelated genes to: CCDC96 antibody
- Gene:
- CCDC96 NIH gene
- Name:
- coiled-coil domain containing 96
- Previous symbol:
- -
- Synonyms:
- FLJ90575
- Chromosome:
- 4p16.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-03-24
- Date modifiied:
- 2014-12-03
Related products to: CCDC96 antibody
Related articles to: CCDC96 antibody
- Non-obstructive azoospermia (NOA) is a severe cause of male infertility. Testicular sperm extraction has limited success, largely due to the absence of reliable, non-invasive biomarkers to predict outcomes. Emerging evidence highlights the role of non-coding RNAs in spermatogenesis, providing promising targets for biomarker development. - Source: PubMed
Publication date: 2026/05/17
Babakhanzadeh EmadKhodadadian AliNazari MajidMozhdeh MahyaFazeli JavadVahidi SerajoddinJafari Mohammad HassanDehghani MohammadrezaGhafouri-Fard SoudehGhasemi Nasrin - Tongue squamous cell carcinoma (TSCC) is clinically heterogeneous, and patients with a similar TNM stage can experience markedly different outcomes. We systematically reviewed omics-driven studies to identify prognostic TSCC biomarkers. Although fundamentally prognostic, we discussed their theoretical translational relevance regarding future clinical decisions-such as treatment stratification or surveillance intensity-while strictly framing them as preliminary, hypothesis-generating targets. PubMed, Scopus, Web of Science, and Cochrane were searched for original human studies published between 2014 and 2024 using high-throughput genomic or transcriptomic profiling. Study selection followed referred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), data were extracted with a structured workbook, and risk of bias was assessed using QUIPS and PROBAST, with reporting completeness appraised using REMARK. Seventeen studies were included, identifying 85 distinct biomarkers. Across biomarkers supported by multivariable overall survival analyses, higher-risk associations were reported for , , , , and , whereas lower-risk associations were reported for , , , , and . Recurrent biological themes included IL-17 signaling, ECM-receptor interaction, and focal adhesion. was the only biomarker reported in more than one included study, supporting its prioritization for validation. Although the evidence remains heterogeneous and largely hypothesis-generating, these markers may support the future validation of response-oriented therapeutic stratification in TSCC. - Source: PubMed
Publication date: 2026/04/10
Astreidis IoannisKostidis IliasMalousi AndigoniParaskevopoulos KonstantinosAndreadis DimitriosVahtsevanos KonstantinosVizirianakis Ioannis - Cilia are hairlike protrusions that project from the surface of eukaryotic cells and play key roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein regulatory complex (N-DRC), which links adjacent doublet microtubules and regulates and coordinates the activity of outer doublet complexes. Despite its critical role in cilia motility, the assembly and molecular basis of the regulatory mechanism are poorly understood. Here, using cryo-electron microscopy in conjunction with biochemical cross-linking and integrative modeling, we localize 12 DRC subunits in the N-DRC structure of Tetrahymena thermophila. We also find that the CCDC96/113 complex is in close contact with the DRC9/10 in the linker region. In addition, we reveal that the N-DRC is associated with a network of coiled-coil proteins that most likely mediates N-DRC regulatory activity. - Source: PubMed
Publication date: 2023/09/15
Ghanaeian AvrinMajhi SumitaMcCafferty Caitlyn LNami BabakBlack Corbin SYang Shun KaiLegal ThibaultPapoulas OpheliaJanowska MartynaValente-Paterno MelissaMarcotte Edward MWloga DorotaBui Khanh Huy - Cilia are hairlike protrusions that project from the surface of eukaryotic cells and play key roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein regulatory complex (N-DRC), which links adjacent doublet microtubules and regulates and coordinates the activity of outer doublet complexes. Despite its critical role in cilia motility, the assembly and molecular basis of the regulatory mechanism are poorly understood. Here, utilizing cryo-electron microscopy in conjunction with biochemical cross-linking and integrative modeling, we localized 12 DRC subunits in the N-DRC structure of . We also found that the CCDC96/113 complex is in close contact with the N-DRC. In addition, we revealed that the N-DRC is associated with a network of coiled-coil proteins that most likely mediates N-DRC regulatory activity. - Source: PubMed
Publication date: 2023/06/01
Ghanaeian AvrinMajhi SumitaMcCaffrey Caitie LNami BabakBlack Corbin SYang Shun KaiLegal ThibaultPapoulas OpheliaJanowska MartynaValente-Paterno MelissaMarcotte Edward MWloga DorotaBui Khanh Huy - Oral tongue squamous cell carcinoma (OTSCC) is a devastating tumor with poor prognosis. There is an urgent need for reliable biomarkers to help predict prognosis and guide treatment for OTSCC. In the current study, we aimed to develop a robust multi-gene signature and prognostic nomogram to predict the prognosis of patients with non-distant metastatic OTSCC. - Source: PubMed
Publication date: 2021/03/09
Liu MuyuanTong LitianLiang BinSong XuhongXie LingzhuPeng HanweiHuang Dongyang