Ask about this productRelated genes to: NOB1 antibody
- Gene:
- NOB1 NIH gene
- Name:
- NIN1 (RPN12) binding protein 1 homolog
- Previous symbol:
- PSMD8BP1
- Synonyms:
- NOB1P, ART-4, MST158
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-27
- Date modifiied:
- 2019-03-15
Related products to: NOB1 antibody
Related articles to: NOB1 antibody
- Processing of the precursor ribosomal RNAs (pre-rRNAs) is a key aspect of ribosomal subunit assembly that is closely coordinated with other maturation events. The ribonucleases that mediate pre-rRNA cleavages require regulation to ensure that their activities are exerted in a timely manner. Post-translational modifications can influence protein functions, and although many human ribosome assembly factors are reported to be post-translationally modified, most of these sites remain unconfirmed and functional insights are lacking. Here, we show that NOB1, the PIN domain endoribonuclease responsible for cleavage of the 3' end of the 18S rRNA, is phosphorylated within an evolutionarily conserved acidic tract that can be modified by casein kinase II in vitro. Association of NOB1 with pre-ribosomes is independent of these phosphorylations, and lack of NOB1 phosphorylation only mildly perturbs the efficiency of SSU maturation events upstream of 3' end cleavage of the 18S rRNA. Interestingly, our analyses of pre-rRNA levels in cells depleted of NOB1 or lacking its catalytic activity revealed not only accumulation of the 18SE precursor of the 18S rRNA, but also altered levels of pre-rRNAs containing 5' external transcribed spacer (ETS) sequences (43S, 26S and 30S). This suggests that lack of NOB1-mediated pre-rRNA cleavage impairs recycling of assembly factors required during early biogenesis steps, leading to altered kinetics of 5' ETS processing. Taken together, these data provide new insights into the role of NOB1 during SSU biogenesis and the post-translational regulation of this ribonuclease. - Source: PubMed
Publication date: 2026/09/10
Bloch von Blottnitz Katja IHonemann-Capito MonaHackert PhilippDybkov OlexandrLenz ChristofBohnsack Markus TLorenz SonjaUrlaub HenningSchneider ClaudiaBohnsack Katherine E - Aberrant expression of , a microRNA involved in tumor suppression, has been associated with a broad range of diseases, including cancer and autoimmune disorders. The gene () is a critical component that plays a pivotal role in the biogenesis and proper functioning of the 26S proteasome. Researchers have found that acts as a regulator of expression by targeting its mRNA, ultimately leading to a decrease in protein translation. - Source: PubMed
Publication date: 2026/07/22
Noei MiladForouzesh FloraAbbasvandi FereshtehZare Amirhossein - - Source: PubMed
Zhang XiangminZhang DongxuQu FajunHong YiCao JianweiPan XiuwuLi LinHuang YiHuang HaiYin LeiChen LuRen JizhongWang ZhijunXu DanfengCui Xingang - The pericarp of Garcinia mangostana (L.) has been traditionally used in Southeast Asia and South China to alleviate diarrhea, regulate gastrointestinal functions, and promote wound healing. It is rich in xanthones, which exhibit significant antimicrobial activity. However, current research on the antimicrobial properties of mangosteen pericarp has primarily concentrated on the antibacterial effects of the xanthone compound α-mangostin, while studies on the antifungal activities of xanthones remain relatively limited. - Source: PubMed
Publication date: 2025/12/03
Li XiancaiChen ShaohuaWu YaodanLiu FenJumai AikebaierZhu BaojunXiong BinghongQiu Sheng-Xiang - The ribosome assembly factors PNO1 and NOB1 play crucial roles in the maturation of the 40S ribosomal small subunit. TurboID is an efficient biotin ligase that can biotinylate proteins in proximity to the target protein and is widely used to study complex biological processes within cells. In this study, we employed this technology to investigate the complex proximity network of PNO1 and NOB1 within the cell, further revealing their key roles in ribosome biogenesis. - Source: PubMed
Publication date: 2025/03/27
Xu XingyuanChen WenliZheng JiefuLiao Jian-YouYan HaiyanZhu Shuang