Ask about this productRelated genes to: GRAP antibody
- Gene:
- GRAP NIH gene
- Name:
- GRB2 related adaptor protein
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-29
- Date modifiied:
- 2018-03-06
Related products to: GRAP antibody
Related articles to: GRAP antibody
- While binge drinking can significantly impact health negatively, it has become increasingly important to understand how sex differences contribute to this hazardous behavior, which may also serve as a risk factor for alcohol use disorder. We employed the binge drinking experimental model we developed previously to specifically analyze sex differences. Forty male and 40 female Long Evans rats were tested in the alcohol self-administration procedure, operationalized as alcohol responding in short daily session. We tested other parameters, including motivation, seeking, responses during cue omission sessions, withdrawal scores, and relapse after abstinence. We also conducted experiments to assess perseverance despite satiety. For the analysis we used first an unsupervised clustering approach using drinking speed and frequency of alcohol responses and then we analyzed our data by taking sex as the differentiating factor. Unbiased clustering analysis revealed four distinct groups: Fast Bingers, Bingers, Extreme Bingers and Low drinkers. Higher alcohol consumption and faster consumption speed correlated with elevated withdrawal scores. Sex-related differences were observed, with females outnumbering males in Extreme bingers. Females also exhibited higher alcohol-seeking behavior, relapse rates, and withdrawal scores. In addition, females exhibit lower sensitivity to devaluation in the satiety test. Our results suggest that females display greater vulnerability to cue-mediated alcohol-seeking behaviors and a more inflexible behavior. This underscores the importance of considering sex as a biological variable in both preclinical and clinical research on binge drinking behaviors that is not only a hazardous behavior but may also be a critical factor in AUD vulnerability, particularly in females. - Source: PubMed
Publication date: 2026/04/29
Jeanblanc JérômeSoyer AmélieNaassila Mickaël - Cobalt and nitrogen co-doped catalysts have been widely reported in Fenton-like processes for water decontamination. However, there is not yet clear how the interaction between cobalt and nitrogen regulates the non-radical electron transfer mechanism. Here, a carbon nanotube (CNT) catalyst (CoN/C-8) containing nitrogen element and a beads-on-string cobalt nanoparticles (Co NPs) was synthesized to utilize peroxymonosulfate (PMS). The CoN/C-8/PMS process exhibited excellent stability and reusability for water treatment, maintaining above 95% of tetracycline hydrochloride (TCH) removal under a continuous-flow operation of 600 min. A series of electrochemical tests, COMSOL multiphysics simulations, and density functional theory calculations collectively elucidate an electron transfer pathway from TCH to the complex of catalyst and PMS (PMS*) and the synergistic effect of graphitic N (Grap-N) and Co NPs during the CoN/C-8/PMS process. Interestingly, although the total number of electrons from the catalyst to PMS increases after the Grap-N interface covering the Co NPs, the main electron donor shifts from the Co NPs to the Grap-N-containing carbon layer interface. These results suggest that the Grap-N interface as an electron transfer highway could protect the easily deactivated cobalt nanoparticles and effectively enhance the stability and life of the catalyst, thus providing valuable guidance for water decontamination. - Source: PubMed
Publication date: 2026/04/29
Liang HaoQin ShuhanZhang XiaonaXu HuiyingZhao MeihuiGuo YangChen JianqiuZuo SijinZhang YinqiaoZhou Minghua - Glutamatergic and dopaminergic dysregulations are major features of alcohol use disorder (AUD). The trace amine-associated receptor 1 (TAAR1), which modulates both systems, has emerged as a promising therapeutic target, although the underlying mechanisms remain unclear. Here, we used male serine racemase knockout (SRKO) mice, a model of chronic NMDA receptor hypofunction and mesolimbic hyperdopaminergia, to investigate how TAAR1 activation shapes alcohol consumption and ethanol-induced dopamine release. Ethanol intake was measured during adolescence and adulthood, and ex vivo fast-scan cyclic voltammetry was used to examine dopamine release in the nucleus accumbens (NAc) core. SRKO mice consumed less alcohol than wild-type controls during adolescence, an effect amplified in adulthood and associated with a blunted dopaminergic response to acute ethanol. Adult SRKO mice previously exposed to alcohol during adolescence displayed an enhanced sensitivity to the TAAR1 full agonist RO5166017, which markedly reduced alcohol consumption and normalized dopamine signaling across groups, leading to similar ethanol-evoked decreases in NAc dopamine release. These findings show that NMDA receptor hypofunction and adolescent alcohol exposure increase TAAR1 signaling sensitivity, making TAAR1 activation particularly effective at reducing alcohol consumption and normalizing dopamine function. This work supports TAAR1 as a relevant molecular target for AUD, especially in conditions involving glutamatergic dysfunction and a history of adolescent alcohol exposure. - Source: PubMed
Publication date: 2026/02/13
Houdant CharlesRouanet CassandreBouet ValentineFreret ThomasBoulouard MichelLeo DamianaJeanblanc JérômeNaassila Mickaël - Optimisation of slaughter weight is crucial for efficient farm management in all-in-all-out systems, but growth variability within pig batches complicates uniform marketing. This study aimed to reduce heterogeneity by developing a decision support system (DSS) for precision feeding, improving BW performance, thereby reducing batch variability. A 103-day commercial trial involving 365 pigs compared conventional 3-phase feeding with individual precision feeding (IPF). Two control groups, Control A and Control B (n = 81 each, six pens/group), received diets with stepwise standardised ileal digestible lysine (SID Lys) concentrations (8.80, 9.80, 10.60 g/kg and 9.00, 10.00, 10.80 g/kg, respectively) from traditional feeders, with feed intake recorded manually. In contrast, the IPF group (n = 203, nine pens) utilised robotic feeders to provide individually tailored diets. These were formulated in real-time by blending high (11.83 g/kg) and low (6.59 g/kg) SID Lys feeds. A DSS, integrating a nutritional model, stakeholder directives (minimum and limited daily decreases in the SID Lys concentration), and a qualitative model, calculated each pig's requirements based on automatically collected real-time BW and feed intake data. Performance metrics were similar across all groups. However, the IPF group (18.55 g/kg) was more efficient in utilising SID Lys, requiring less per kg of live weight gain than Control A (19.67 g/kg) and Control B (19.71 g/kg). When pigs were classified by initial BW - heavy (HBW, IPF: 26; Control A: 23; Control B: 20 animals), moderate (MBW, IPF: 98; Control A: 39; Control B: 41 animals) and light-body-weight (LBW, IPF: 79; Control A: 19; Control B: 20 animals) - the IPF group showed an improvement of 4.2-6.8 kg in growth performance for HBW, and 2.6-4.3 kg in LBW, compared to controls, although not statistically significant. While overall batch variability remained similar (CV: 11.6% IPF, 11.9% Control A, 12.2% Control B), the IPF group was more homogeneous among LBW pigs (9.5%) compared to controls (11.5% and 13.8%). Greater HBW variation in IPF group balanced overall variability. Although direct feed cost savings and nitrogen excretion reductions were not achieved - attributed to technical feed distribution issues in the final phase and higher CP baselines in the experimental diets - an economic estimation revealed that the system's profitability was driven by output maximisation. In conclusion, the DSS proved feasible for real-time commercial application, successfully enhancing nutrient utilisation efficiency and optimising the growth of animals at the extremes of the population distribution. - Source: PubMed
Publication date: 2026/01/20
Sacanell V LPlà-Aragonés L MPomar J - At the national and state levels, data on changes over time in fruit and vegetable intake among young children are limited. Using nationally representative data from the National Survey of Children's Health during 2021-2023, we examined trends in daily fruit and vegetable intake among children aged 1 to 5 years. We conducted trend analyses nationally, by age, and by state. We found no significant linear trends in daily fruit or vegetable intake at the national level or by age. At the state level, fruit intake increased significantly from 2021 to 2023 in Connecticut (from 65.8% to 77.2%; = .049), Illinois (from 68.5% to 77.8%; = .03), and Montana (from 66.1% to 81.0%; = .01) and decreased significantly in Massachusetts (from 82.2% to 65.0%; = .001); no state had significant changes in daily vegetable intake. Lack of improvement in daily fruit and vegetable intake among young children emphasizes the continued need for monitoring and evidence-based interventions. - Source: PubMed
Publication date: 2026/01/28
Awan SofiaGrap Mary EllenGoding Sauer Ann MMarks Kristin JSelf Julie LDooyema Carrie AHamner Heather C