Ask about this productRelated genes to: WDR66 antibody
- Gene:
- WDR66 NIH gene
- Name:
- WD repeat domain 66
- Previous symbol:
- -
- Synonyms:
- MGC33630, CaM-IP4
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-26
- Date modifiied:
- 2014-07-31
Related products to: WDR66 antibody
Related articles to: WDR66 antibody
- The progressive process from normal oral tissue (ONT) to precancerous lesions (oral dysplasia [OD], leukoplakia-oral precancerous lesion [OPL]) and ultimately to oral squamous cell carcinoma (OSCC) involves dynamic molecular and immunological alterations. - Source: PubMed
Publication date: 2025/10/29
Liao ZixuanLi XiaofeiMa QingchenShi ChengWang XuanZhang Yang - CircRNAs are implicated in colorectal cancer (CRC) development and progression. Protein O-fucosyltransferase 1 (POFUT1) plays an oncogenic role via activating Notch1 signaling in CRC. However, the roles of circPOFUT1, which is originated from POFUT1, have not been investigated. Our study showed circPOFUT1 was highly expressed in CRC tissues and cells. CircPOFUT1 enhanced the proliferation, migration and invasion of CRC cells, and promoted tumor growth and liver metastasis . It also reinforced stemness and chemoresistance of CRC cells. Mechanistically, circPOFUT1 regulated the function of E2F7 via sponging miR-653-5p, thereby transcriptionally inducing WDR66 expression and further promoting metastasis in CRC. On the other hand, circPOFUT1 promoted stemness and chemoresistance of CRC cells via stabilizing BMI1 in an IGF2BP1-dependent manner. In conclusion, circPOFUT1 fosters CRC metastasis and chemoresistance via decoying miR-653-5p/E2F7/WDR66 axis and stabilizing BMI1. - Source: PubMed
Publication date: 2023/12/14
Long FeiTian BuningLi LiangMa MinChen ZhijianTan GuojiangYin NingZhong ChongleiYu BowenGuo YihangChen MiaoHu Gui - Male infertility is common and complex, presenting a wide range of heterogeneous phenotypes. Although about 50% of cases are estimated to have a genetic component, the underlying cause often remains undetermined. Here, from whole-exome sequencing on samples from 168 infertile men with asthenoteratozoospermia due to severe sperm flagellum, we identified homozygous variants in four unrelated patients. In sperm cells from these individuals, immunofluorescence revealed altered localization of DNAH1, DNALI1, WDR66, and TTC29. Axonemal localization of ZMYND12 ortholog TbTAX-1 was confirmed using the model. RNAi knock-down of TbTAX-1 dramatically affected flagellar motility, with a phenotype similar to the sperm from men bearing homozygous variants. Co-immunoprecipitation and ultrastructure expansion microscopy in revealed TbTAX-1 to form a complex with TTC29. Comparative proteomics with samples from and KO mice identified a third member of this complex: DNAH1. The data presented revealed that ZMYND12 is part of the same axonemal complex as TTC29 and DNAH1, which is critical for flagellum function and assembly in humans, and . ZMYND12 is thus a new asthenoteratozoospermia-associated gene, bi-allelic variants of which cause severe flagellum malformations and primary male infertility. - Source: PubMed
Publication date: 2023/11/07
Dacheux DenisMartinez GuillaumeBroster Reix Christine EBeurois JulieLores PatrickTounkara MagambaDupuy Jean-WilliamRobinson Derrick RoyLoeuillet CorinneLambert EmelineWehbe ZeinaEscoffier JessicaAmiri-Yekta AmirDaneshipour AbbasHosseini Seyedeh-HaniehZouari RaoudhaMustapha Selima Fourati BenHalouani LazharJiang XiaohuiShen YingLiu ChunyuThierry-Mieg NicolasSeptier AmandineBidart MarieSatre VéroniqueCazin CarolineKherraf Zine EddineArnoult ChristopheRay Pierre FToure AminataBonhivers MélanieCoutton Charles - Although male factor accounts for 40%-50% of unintended childlessness, we are far from fully understanding the detailed causes. Usually, affected men cannot even be provided with a molecular diagnosis. - Source: PubMed
Publication date: 2023/04/13
Greither ThomasDejung MarioBehre Hermann MButter FalkHerlyn Holger - - Source: PubMed