Ask about this productRelated genes to: IFI44 antibody
- Gene:
- IFI44 NIH gene
- Name:
- interferon induced protein 44
- Previous symbol:
- -
- Synonyms:
- MTAP44, p44, TLDC5
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-19
- Date modifiied:
- 2015-11-27
Related products to: IFI44 antibody
Related articles to: IFI44 antibody
- Malignant progression of bladder cancer (BC) is frequently caused by its complex molecular regulation, leading to unfavorable clinical outcomes. Our research indicates that interferon-induced protein 44 (IFI44) is significantly overexpressed in BC, thereby facilitating its malignant progression. Mechanistically, BC's progression is impeded by the knockdown of IFI44, partially due to the inhibition of the PI3K/AKT signaling pathway. In addition, we constructed a Zeolitic Imidazolate Framework-8 (ZIF-8) nanoplatform, incorporating ZIF-8@siIFI44, ZIF-8@siIFI44@PEG and ZIF-8@siIFI44@PEG-RGD. Subsequent experiments demonstrated that ZIF-8@siIFI44 and ZIF-8@siIFI44@PEG possess anti-tumor property, while ZIF-8@siIFI44@PEG-RGD exhibited enhanced anti-tumor efficacy due to the inclusion of RGD targeting peptides which especially target tumors. Additionally, our study confirmed that the ZIF-8 nanoplatform enables targeted delivery of IFI44 siRNA, therefore preventing BC development partially by influencing the PI3K/AKT signaling pathway. Our findings identify IFI44 as an element that aids in the malignant development of BC, emphasizing its promise as a target for therapy. - Source: PubMed
Publication date: 2026/04/30
Zhu ChaoLiu MengweiLiu XiaohuaZhang SifanHe YunChen MengHuang HaoxuanYu KuaiLe Aiping - Bovine viral diarrhea virus (BVDV) strains of differing virulence are associated with distinct clinical and lymphoid outcomes, but transcriptional responses within peripheral lymphocyte compartments remain incompletely defined. Here, we performed RNA-seq on CD4/CD8β/TcR1 bead-enriched peripheral lymphocyte fractions from calves experimentally infected with low-virulence or high-virulence noncytopathic BVDV strains (BVDV2-RS886 and BVDV2-1373, respectively) and sampled on days 0, 3, and 15 days post-inoculation. Because group sizes were small (n = 3 per group), analyses were interpreted as exploratory. Marker-gene analyses indicated that the sequenced material represented a T-cell-enriched but compositionally heterogeneous peripheral lymphocyte fraction. At day 3, both infection groups showed strong induction of interferon-responsive genes, including OAS family members, ISG15, IFI44/IFI44L, RSAD2, DDX58, and ZBP1. The high-virulence group additionally showed broader reduction of transcripts associated with lymphocyte signaling, trafficking, and biosynthetic activity. By day 15, the low-virulence group showed only a small residual response, whereas the high-virulence group remained broadly perturbed, with reduced abundance of multiple adaptive immune and antigen-presentation-associated transcripts in the bead-enriched fraction. These data define divergent temporal transcriptomic trajectories associated with BVDV2 virulence and provide a hypothesis-generating resource for future studies using phenotypically defined bovine lymphocyte subsets. - Source: PubMed
Publication date: 2026/04/23
Bauermann Fernando VicosaBayles Darrell OFalkenberg Shollie MMaggioli Mayara FRidpath Julia F - Pregnancy loss (PL) in lactating dairy cows disrupts reproductive efficiency, yet the timing and physiological mechanisms underlying early losses remain poorly defined. We evaluated cervical interferon-stimulated gene (ISG) expression (d12, d14, and d16 after artificial insemination [AI] in inseminated cows; corresponding days of the estrous cycle in cyclic controls), circulating progesterone (P4; d12, d14, d16, and d21 after AI or equivalent cycle days), and pregnancy-associated glycoprotein (PAG; d28 after AI) profiles in lactating Holstein cows (n = 67; 57 inseminated and 10 cyclic controls) to characterize temporal patterns associated with pregnancy establishment and loss, and to infer the timing of pregnancy loss. Pregnancy was also diagnosed by transrectal ultrasonography on d28 and d60. Based on individual longitudinal ISG profiles, evidence of conceptus signaling (≥2.5-fold increase in d12, d14 and/or d16) was detected in 94.7% of inseminated cows, indicating 5.3% loss before d12 (non-fertilization or early embryo degeneration). Subsequent PL occurred in 9.3% (5/54) of cows between d12 and d16 (elevated ISG15 on d12 and d14 but not on d16), in 32.7% (16/49) between d16 and d21 (elevated ISG15 on d16 but low P4 by d21), in 24.2% (8/33) between d21 and d28 (elevated ISG15 d16, elevated P4 d21, but no embryo or PAG on d28), and in 20.0% (5/25) between d28 and d60 (embryo and PAG d28 but no embryo d60), resulting in pregnancy per AI of 43.8% at d28 and 35.1% at d60. For cows with PL from d12-d16 or PL d16-21, corpus luteum (CL) regression was detectable by d21 (low P4, ≤ 1 ng/mL). In contrast, cows with PL between d21 and d28 exhibited ISG and P4 profiles similar to pregnant cows through d16-21 but had lower PAG concentrations on d28. Cows with PL between d28 and d60 had PAG concentrations consistent with pregnancy at d28, indicating conceptus attachment followed by subsequent pregnancy failure. An exploratory evaluation of other ISGs in the cervical cytobrush collections on d12, d14, and d16 in a subset of cows (n = 32) indicated that they provided complementary information to ISG15, although IFI44 enabled detection of pregnant cows at the earliest time point (d12). In conclusion, PL before d21 was associated with patterns consistent with reduced conceptus interferon signaling and insufficient luteal support, whereas PL after d21 occurred despite evidence of early conceptus signaling and functional luteal maintenance, suggesting a shift from failure of pregnancy recognition to failure of pregnancy maintenance. Cervical ISG profiling may provide a useful approach to determine the timing and underlying biology of PL in dairy cows. - Source: PubMed
Publication date: 2026/04/23
Vivián Rodrigode Brun VictoriaNaya HugoGil Jorgede Lourdes Adrien MariaWiltbank Milo CMeikle Ana - Although IFI44 is recognized for its crucial role in autoimmune disorders, its function in breast cancer (BC) remains unclear. This study aimed to investigate the immune-related and prognostic significance of IFI44 in BC. - Source: PubMed
Publication date: 2026/04/08
Wu JiahuiYi WangLiu MengtingLi YingliangZhou BoxuanWu ZiyunCao WeiShi QingfengCai XiangkaiXiong Haiwei - Sepsis, a life-threatening condition with high mortality, is closely linked to energy metabolism (EM) and immune-inflammatory responses. However, the precise mechanisms remain incompletely understood. This research aims to identity EM-related genes (EMRGs) in sepsis and examine the diagnostic potential and molecular mechanisms through machine learning and single-cell RNA sequencing (scRNA-seq). - Source: PubMed
Publication date: 2026/02/03
Yu XiaoLiu CongruiJia LibinWan BingjieFeng JunWu YonghongTang JinJia YachunLiu HongweiLuo SiyuLi QiaoKong GuangyaoLi Ping