Ask about this productRelated genes to: CHKA antibody
- Gene:
- CHKA NIH gene
- Name:
- choline kinase alpha
- Previous symbol:
- CHK
- Synonyms:
- CKI
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-01-15
- Date modifiied:
- 2016-10-05
Related products to: CHKA antibody
Related articles to: CHKA antibody
- This study aimed to comprehensively analyze differentially expressed genes (DEGs) in chondrocytes from patients with knee osteoarthritis (OA) by integrating multiple machine learning algorithms and bioinformatics techniques, to unravel the underlying molecular mechanisms associated with OA chondrocytes, and to provide novel insights for the innovation of clinical therapeutic strategies. - Source: PubMed
Publication date: 2026/06/16
Zhuge Jing-leLi Xi-YongWang Yong-leMa Juan-Fen - Cholesterol metabolism is critical in cancer biology, yet its role in hepatocellular carcinoma (HCC) remains poorly understood. We investigated the expression and prognostic significance of cholesterol homeostasis genes in HCC to identify potential biomarkers for risk stratification. Using data from The Cancer Genome Atlas, we identified differentially expressed cholesterol-related genes (logFC ≥ 1.5, false discovery rate < 0.05), intersecting them with genes annotated in the Molecular Signatures Database. Prognostic biomarkers were evaluated using univariate and multivariate Cox regression. A predictive model was constructed to assess survival outcomes. Cholesterol homeostasis genes, particularly fatty acid-binding protein 5 (FABP5) and alcohol dehydrogenase 4 (ADH4), are key prognostic biomarkers in HCC. The proposed model provides a novel approach for predicting outcomes and may inform therapeutic strategies. Further studies are needed to validate these findings and explore their clinical utility. Nine cholesterol homeostasis genes were differentially expressed, including 6 upregulated (choline kinase alpha, FABP5, fatty acid synthase, farnesyl diphosphate synthase, mevalonate diphosphate decarboxylase, and squalene epoxidase) and 3 downregulated (ADH4, activating transcription factor 5, and arginine vasopressin receptor 1A). FABP5 and ADH4 emerged as independent prognostic factors: high FABP5 expression was associated with poor prognosis, while high ADH4 expression predicted improved survival. A prognostic model integrating FABP5 and ADH4 and clinical characteristics achieved a concordance index of 0.683, effectively stratifying patients into high-risk and low-risk groups (χ2 = 20.60, P < .001) with median survival times of 1135 and 2532 days, respectively. - Source: PubMed
Ding ChongyuHuo JianghuaXu Ya-QianZhang HuiGong YuluHao DarongMeng Dan - Pork is a primary dietary protein source for humans, with its lipid composition being a critical determinant of meat quality and nutritional value. Existing studies have confirmed that intramuscular fat (IMF) and subcutaneous fat possess distinct lipid metabolic profiles. However, the lipid profiles of cultured fats from distinct seed cells remain uncharacterized. Here, we compared lipid composition of cultured fats produced from porcine subcutaneous pre-adipocytes (SAT) and fibro-adipogenic progenitors (FAPs) using a liquid chromatography-mass spectrometry approach. The FAPs-derived cultured fat exhibited significantly lower total lipid content but higher proportions of glycerophospholipids, whereas SAT-derived cultured fat showed higher levels of triglycerides and ceramides. Transcriptomics revealed distinct expression patterns of key genes involved in glycerolipid, glycerophospholipid, and sphingolipid metabolism, including DGAT1/2, CHKA, CHPT1, CEPT1, and CERS1, underpinning the observed lipid differences. Our findings provide insights into cell-type-specific lipid characteristics and a basis for optimizing cultured fat nutritional quality via seed cell selection. - Source: PubMed
Publication date: 2026/05/17
Gu XinLi QianqianLiu ShiqiTan Lay PohValencak Teresa GShan Tizhong - Variants in the CHKA gene, encoding choline kinase alpha (CHKA), are associated with epilepsy, intellectual disability, and movement disorders. The neurobiological mechanisms remain unclear. This study examined neuronal subcellular structural changes and molecular pathways in CHKA deficiency. - Source: PubMed
Publication date: 2026/04/24
Liu Hai-BoQian XinChen Shi-DongFeng JinZou You-RuiLiu YangGao PengMa Hui - Glutamine metabolism is essential for tumor cell proliferation and biosynthesis. However, solid tumors often face chronic glutamine deprivation, and the underlying adaptive mechanisms remain incompletely understood. Here, we show that glutamine scarcity upregulates choline kinase alpha (CHKA), whose monomerization enhances its noncanonical protein kinase activity. CHKA phosphorylates promyelocytic leukemia (PML) at tyrosine 339, promoting its cytoplasmic localization. Notably, this reflects a compartment-specific switch in PML activity: while nuclear PML facilitates protein degradation through Small Ubiquitin-like Modifier (SUMO)-ubiquitin cascades, cytoplasmic PML acts oppositely to block degradation. Specifically, cytoplasmic PML then induces SUMOylation of WD Repeat Domain Phosphoinositide-Interacting Protein 2 (WIPI2) at lysines 281 and 283, thereby blocking HUWE1-mediated ubiquitination and proteasomal degradation. Stabilized WIPI2 increases autophagic flux, supporting tumor cell survival under metabolic stress. This study identifies a critical CHKA-PML-WIPI2 axis mediating adaptation to glutamine deprivation, providing insight into metabolic plasticity and a potential therapeutic target for glutamine-dependent cancers. - Source: PubMed
Publication date: 2026/03/19
Wang RuijieCao LeixiHe XianweiThorne Rick FrancisWu QichenDing CaoyuanZhang JinjingLi MengfanShi ZeyuanDong XinyiLi JingLi HongxiangGao SuhuaLi JinmingZhang Xu DongJin LeiFan TianliWu Mian