Ask about this productRelated genes to: STK32A antibody
- Gene:
- STK32A NIH gene
- Name:
- serine/threonine kinase 32A
- Previous symbol:
- -
- Synonyms:
- MGC22688, YANK1
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-20
- Date modifiied:
- 2018-05-17
Related products to: STK32A antibody
Related articles to: STK32A antibody
- Lung adenocarcinoma (LUAD) represents an aggressive malignancy characterized by high metastatic potential. Emerging evidence suggests mitochondrial DNA methylation (MTDM) plays a pivotal role in regulating gene expression through protein synthesis modulation, yet its mechanistic involvement in LUAD pathogenesis remains poorly understood. - Source: PubMed
Publication date: 2026/02/10
Ding JianCheng GangXue QianGuo WeizhenCheng YikunYang ChengTong JiabingLi ZegengGao Yating - Classical studies identified a critical role for the hypothalamus in regulating sleep and wake states, but few such hypothalamic neuronal populations have been identified. Here, we describe a sleep-promoting population of hypothalamic neurons that expresses the neuropeptides QRFP and parathyroid hormone 4 (Pth4) in zebrafish. Optogenetic stimulation of these neurons results in a large increase in sleep that requires pth4 but not qrfp. Noradrenergic locus coeruleus (LC) neurons and serotonergic (5HT) raphe nuclei (RNs) in the hindbrain express distinct pth receptors, and genetic epistasis and cell ablation experiments revealed that Pth4 neuron-induced sleep is suppressed in mutants that lack noradrenaline in the LC or lack the 5HT RNs. Pth4 neuron-induced sleep is also suppressed in serine/threonine kinase 32a (stk32a) mutants, possibly via stk32a-expressing neurons in the prethalamus that express pth receptors. These results identify QRFP/Pth4 neurons as a novel hypothalamic sleep-promoting population and support a model in which distinct sleep- and wake-promoting hypothalamic populations act via monoaminergic neurons in the hindbrain to control vigilance state. - Source: PubMed
Publication date: 2025/12/16
Herget UlrichTran StevenSingh ChanpreetOikonomou GrigoriosRyu SoojinRotllant JosepProber David A - As a subgroup of AGC kinases, serine/threonine kinase 32 family (STK32, also known as Yet Another Novel Kinases family) consists of three members: STK32A, STK32B and STK32C. Recently, emerging evidences have implicated the aberrant expression and dysregulated functions of STK32 kinases in human malignancies. However, there is a lack of systematic review on this topic. Here, we aim to detailly examine the expression and functional features of STK32 family kinases within the context of present reports and public datasets related, and outline current understanding on the multifunctional roles and up-stream regulatory mechanisms and down-stream effectors of STK32 kinases to highlight key research focus for future exploration and provide rationale for developing STK32-targeted therapeutics in cancer. - Source: PubMed
Publication date: 2025/11/22
Liu LongqiaoFeng YuanLiu YangCheng LinCheng Peng - Hair cells in the utricle and saccule form two groups with oppositely oriented stereociliary bundles that enable detection of broad ranges of motion. These groups are aligned along a common polarity axis established by core planar cell polarity (PCP) proteins, which individual cells interpret differently to generate opposing bundle orientations. EMX2, GPR156 and STK32A determine how these groups integrate PCP signaling during this process. We tested functional interactions between these factors using genetic epistasis experiments and evaluating hair cells in mice with combined mutations in Gpr156 and Stk32a or Emx2 and Stk32a. We show in the utricle that: (1) GPR156 functions to reverse stereociliary bundles relative to the PCP axis but can be blocked by STK32A; and (2) EMX2 establishes the boundary between the two groups by repressing Stk32a transcription. We further demonstrate that these factors have similar functional relationships in the cochlea, despite the absence of polarity reversal in that tissue. Together, these phenotypes support a mechanism whereby EMX2 regulates Stk32a transcription, thereby allowing GPR156 to reverse the orientation of stereociliary bundles in one group of hair cells. - Source: PubMed
Publication date: 2025/12/11
Jia ShihaiGoodrich Ellison JTarchini BasileDeans Michael R - Classical studies identified a critical role for the hypothalamus in regulating sleep and wake states, but few such hypothalamic neuronal populations have been identified. Here we describe a sleep-promoting population of hypothalamic neurons that expresses the neuropeptides QRFP and parathyroid hormone 4 (Pth4) in zebrafish. Optogenetic stimulation of these neurons results in a large increase in sleep that requires but not . Noradrenergic locus coeruleus (LC) neurons and serotonergic raphe neurons (RN) in the hindbrain express distinct , and genetic epistasis and cell ablation experiments revealed that Pth4 neuron-induced sleep is suppressed in mutants that lack noradrenaline in the LC or lack the serotonergic RN. Pth4 neuron-induced sleep is also suppressed in () mutants, possibly via -expressing neurons in the prethalamus that express . These results identify QRFP/Pth4 neurons as a novel hypothalamic sleep-promoting population and support a model in which distinct sleep- and wake-promoting hypothalamic populations act via monoaminergic neurons in the hindbrain to control vigilance state. - Source: PubMed
Publication date: 2025/09/11
Herget UlrichTran StevenSingh ChanpreetOikonomou GrigoriosRyu SoojinRotllant JosepProber David A