Ask about this productRelated genes to: KIAA0515 antibody
- Gene:
- PRRC2B NIH gene
- Name:
- proline rich coiled-coil 2B
- Previous symbol:
- KIAA0515, BAT2L, BAT2L1
- Synonyms:
- MGC10526, LQFBS-1
- Chromosome:
- 9q34.13
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-27
- Date modifiied:
- 2016-01-25
Related products to: KIAA0515 antibody
Related articles to: KIAA0515 antibody
- Ischemic brain injury (IBI) is a severe neurological disorder with poorly defined pathogenesis and limited treatments. Cold-inducible RNA-binding protein (CIRBP) mediates stress responses, yet its post-transcriptional regulatory role in IBI remains unclear. This study investigated CIRBP's function and mechanisms to provide IBI therapeutic insights. - Source: PubMed
Publication date: 2026/06/23
Tang DangLong JiangGao BiboRen Zhongkun - To analyze the heterogeneity of response to first-line camrelizumab combined with chemotherapy in patients with esophageal squamous cell carcinoma (ESCC) by pretreatment circulating cell-free DNA (cfDNA) sequencing. A total of 30 patients with human epidermal growth factor receptor 2-negative locally advanced or advanced ESCC who received first-line camrelizumab combined with chemotherapy in the Department of Oncology, Changzhi People's Hospital, from June 2020 to April 2023 were enrolled. Follow-up was conducted until May 30, 2024, with a median follow-up duration of 15.9 months. Differences in cfDNA sequencing profiles between the ORR group (complete response + partial response, =15), and the Non-ORR group (stable disease + progressive disease, =15), were analyzed. Base substitution types, functional mutation categories, and mutation frequencies were compared to identify differentially mutated cfDNA genes. The associations between gene mutation status and progression-free survival (PFS) and overall survival (OS) were further evaluated. In both the Non-ORR and ORR groups, the insert fragment lengths showed a unimodal distribution (160-180 bp), consistent with the typical characteristics of cfDNA. C>T transition was the predominant base substitution type (47.6% in the Non-ORR group and 45.9% in the ORR group). Missense mutation was the most common functional mutation type (80.9% in the Non-ORR group and 81.1% in the ORR group). Six differentially mutated genes were identified between the Non-ORR and ORR groups, including , , , , , and . Mutations in , , and may be associated with lack of objective response (all ＜0.05), whereas mutations may be associated with a better treatment response (=0.050). Survival analysis showed that, within the sample size and follow-up period of this cohort, the median PFS of patients with mutant-type and wild-type was not reached and 9.70 months, respectively, and the median OS was 30.90 and 17.80 months, respectively. mutation was associated with better PFS (=2.658, =0.049 7) and better OS (=3.029, =0.033). After treatment with camrelizumab combined with chemotherapy for ESCC, molecular characteristics differ among patients with different treatment responses. mutation is associated with improved PFS and OS. However, these findings require further validation in larger cohorts. - Source: PubMed
Zhang X LWang HFan W XSong G HGuo Z DDu Y YZhang Y XSu FYang BLiu MGao Y JHu W QZhao J - Regulation of mRNA translation is essential for cellular homeostasis, and its dysregulation contributes to cancer, neurodegeneration, and developmental disorders. Stress granules are cytosolic condensates that form during stress-induced translation arrest and are enriched in mRNAs, translation factors, and RNA-binding proteins, but how stress granule proteins modulate translation remains poorly understood. Here, we identify the stress granule components Proline-Rich Coiled-Coil A, B, and C (PRRC2 proteins) as translation regulators. PRRC2 proteins are large, intrinsically disordered paralogs conserved across jawed vertebrates. Functional proteomics revealed that all PRRC2 proteins associate with the 48S translation initiation complex (PIC), whereas PRRC2B additionally interacts with nuclear proteins. Under stress, the proximal interaction network of PRRC2 proteins undergoes dynamic remodeling, including increased interactions with the stress granule scaffold G3BP1. Genetic perturbation shows that the PRRC2 proteins influence stress granule assembly in a context-specific manner, and are collectively required for cell growth in basal conditions due to their essential role in translation. Cells with reduced PRRC2 proteins exhibit a significant reduction in the abundance of more than half of the proteome, with a bias toward translational targets of eIF3d and eIF4G2. Interaction domain mapping and AlphaFold3 modeling revealed that an α helix within the putative coiled-coil domain of PRRC2C mediates interactions with the eIF3 core complex. This modeling places the PRRC2C α helix in a previously unassigned region of a published cryo-EM density map, validating the protein interaction and the mechanistic role of PRRC2C in translation control. Together, these findings establish PRRC2 proteins as components of the translation initiation machinery that regulate translation through their interactions with the eIF3 complex and other components of the 48S PIC factors, providing a direct mechanistic link between stress granule proteins and translational control. - Source: PubMed
Publication date: 2026/02/25
Huang Jie QiKadijk EileighSchreiber Karl JLiu Zi HaoChiang Rachel WZhang ZhixinGuttman KevinHuang Tian HaoAlmeida Sylvia M TZhulyn OlenaMoses AlanForman-Kay Julie DRubinstein John LYoun Ji-Young - PRRC2B is an intrinsically disordered RNA-binding protein that is part of the cell's translation machinery. Here, we show that PRRC2B has two alternatively spliced mRNA transcripts producing major long and minor short isoforms. Mass spectrometry-based interaction studies indicated that both isoforms associate with the 40S ribosomal subunit and translation initiation factors. Importantly, the long isoform also interacted with additional RNA-binding proteins through its unique Arg/Gly-rich region. Among these is LARP1, a regulator of 5' terminal oligopyrimidine (TOP) mRNAs under conditions of mTOR inhibition. We discovered that, like LARP1, PRRC2B-long isoform binds to 5' TOP mRNAs. Moreover, it is necessary for the post-transcriptional preservation of their mRNA levels, particularly those encoding ribosomal proteins, during amino acid starvation. In its absence, the rapid de novo translation of ribosomal proteins that takes place upon nutrient recovery is impeded. Overall, our study elucidates a newly discovered function for PRRC2B as an RNA-binding protein that regulates ribosomal biogenesis upon metabolic shift, in addition to its established function in initiating translation of specific mRNA targets. - Source: PubMed
Goldberg NadavBril DoronEisenstein MiriamOlender TsviyaSavidor AlonBialik ShaniPietrokovski ShmuelKimchi Adi - Chronic venous disease (CVD) is a prevalent condition in adults, significantly affecting the global elderly population, with a higher incidence in women than in men. The modulation of gene expression through microRNA (miRNA) partly regulated the development of cardiovascular disease (CVD). Previous research identified a functional analysis of seven genes (CDS2, HDAC5, PPP6R2, PRRC2B, TBC1D22A, WNK1, and PABPC3) as targets of miRNAs related to CVD. In this context, miRNAs emerge as essential candidates for CVD diagnosis, representing novel molecular and biological knowledge. This work aims to identify, by network analysis, the miRNAs involved in CVD as potential biomarkers, either by interacting with small molecules such as toxins and pollutants or by searching for new drugs. Our study shows an updated landscape of the signaling pathways involving miRNAs in CVD pathology. This latest research includes data found through experimental tests and uses predictions to propose both miRNAs and genes as potential biomarkers to develop diagnostic and therapeutic methods for the early detection of CVD in the clinical setting. In addition, our pharmacological network analysis has, for the first time, shown how to use these potential biomarkers to find small molecules that may regulate them. Between the small molecules in this research, toxins, pollutants, and drugs showed outstanding interactions with these miRNAs. One of them, hesperidin, a widely prescribed drug for treating CVD and modulating the gene expression associated with CVD, was used as a reference for searching for new molecules that may interact with miRNAs involved in CVD. Among the drugs that exhibit the same miRNA expression profile as hesperidin, potential candidates include desoximetasone, curcumin, flurandrenolide, trifluridine, fludrocortisone, diflorasone, gemcitabine, floxuridine, and reversine. Further investigation of these drugs is essential to improve the treatment of cardiovascular disease. Additionally, supporting the clinical use of miRNAs as biomarkers for diagnosing and predicting CVD is crucial. - Source: PubMed
Publication date: 2024/10/15
Barrera-Vázquez Oscar SalvadorEscobar-Ramírez Juan LuisMagos-Guerrero Gil Alfonso