Ask about this productRelated genes to: QRSL1 antibody
- Gene:
- QRSL1 NIH gene
- Name:
- glutaminyl-tRNA amidotransferase subunit QRSL1
- Previous symbol:
- -
- Synonyms:
- GatA, FLJ10989, FLJ12189, DKFZP564C1278, FLJ13447
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-06
- Date modifiied:
- 2019-01-22
Related products to: QRSL1 antibody
Related articles to: QRSL1 antibody
- Mitochondrial dysfunction is implicated in mitral valve diseases (MVD), but specific genetically predicted genes and molecular mechanisms remain undefined. - Source: PubMed
Publication date: 2026/07/16
Tian BaiyuMeng FeiWang JiangangZhang HaiboLuo TiangeFu JintaoLiu KeminZhang WenboZhao ChengJiao YuqingSun Junhui - Tilapia ( spp.) is a globally important farmed fish. Analyses of genetic variation across different types of tilapia are essential for the development of superior breeding populations. We investigated the genetic structures of breeding populations of blue tilapia () (OA), Nile tilapia () (ON), and red tilapia ( spp.) (OS) by whole-genome resequencing. The results showed that the OS population had maintained high genetic diversity but significant genetic differentiation from the OA population. Principal component analysis, phylogenetic analysis, and genetic clustering analysis revealed a clear pattern of genetic differentiation among the three populations. The genetic structure of the ON population differed from that of the OA population but was similar to that of the OS population. Population kinship analysis revealed a close relationship between the ON and OS populations. Selective scanning analyses of three comparison groups (OA vs. ON, OA vs. OS, and ON vs. OS) revealed population-selected regions related to metabolism, endocrine, and immune systems, harboring key genes (, , , , , , , , and ). These key genes were related to growth, reproduction, and disease resistance, indicating that breeding programs have selected for these traits. Due to the lack of stable morphological characteristics of juvenile fish and the changes in external environmental conditions that lead to changes in individual morphological characteristics, SNP fingerprints were successfully constructed for the identification of the three populations based on the differences in SNPs. Based on the five core SNP markers, two combinations of SNP markers were developed to accurately identify the three populations of tilapia at the genomic level. These results provide new information about tilapia genetic resources and reference data for identification and breeding purposes. - Source: PubMed
Publication date: 2025/05/20
Hua JixiangTao YifanLu SiqiWang QingchunSun HuiDong YalunQiang Jun - The 3D multicellular tumor spheroid (MTS) model exhibits enhanced fidelity in replicating the tumor microenvironment and demonstrates exceptional resistance to clinical drugs compared to the 2D monolayer model. In this study, we used multiomics (transcriptome, proteomics, and metabolomics) tools to explore the molecular mechanisms and metabolic differences of the two culture models. Analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathways revealed that the differentially expressed genes between the two culture models were mainly enriched in cellular components and biological processes associated with extracellular matrix, extracellular structural organization, and mitochondrial function. An integrated analysis of three omics data revealed 11 possible drug resistance targets. Among these targets, seven genes, AKR1B1, ALDOC, GFPT2, GYS1, LAMB2, PFKFB4, and SLC2A1, exhibited significant upregulation. Conversely, four genes, COA7, DLD, IFNGR1, and QRSL1, were significantly downregulated. Clinical prognostic analysis using the TCGA survival database indicated that high-expression groups of SLC2A1, ALDOC, and PFKFB4 exhibited a significant negative correlation with patient survival. We further validated their involvement in chemotherapy drug resistance, indicating their potential significance in improving prognosis and chemotherapy outcomes. These results provide valuable insights into potential therapeutic targets that can potentially enhance treatment efficacy and patient outcomes. - Source: PubMed
Wang TongWang XuetingZheng XuliGuo ZhongfangMohsin AliZhuang YingpingWang Guan - Salt stress is one of the most important factors limiting rice growth and yield increase. Salt tolerance of rice at the bud burst (STB) stage determines whether germinated seeds can grow normally under salt stress, which is very important for direct seeding. However, reports on quantitative trait loci (QTLs) and candidate genes for STB in rice are very limited. In this study, a natural population of 130 indica and 81 japonica rice accessions was used to identify STB-related QTLs and candidate genes using a genome-wide association study (GWAS). Nine QTLs, including five for relative shoot length (RSL), two for relative root length (RRL), and two for relative root number (RRN), were identified. Five of these STB-related QTLs are located at the same site as the characterized salt tolerance genes, such as , , and . However, an important QTL related to RSL, , has not been previously identified and was detected on chromosome 1. The candidate region for was identified by linkage disequilibrium analysis, 18 genes were found to have altered expression levels under salt stress through the RNA-seq database, and 10 of them were found to be highly expressed in the shoot. It was also found that, eight candidate genes (, , , , , , and ) for carry different haplotypes between indica and japonica rice, which exactly corresponds to the significant difference in RSL values between indica and japonica rice in this study. Most of the accessions with elite haplotypes were indica rice, which had higher RSL values. These genes with indica-japonica specific haplotypes were identified as candidate genes. Rice accessions with elite haplotypes could be used as important resources for direct seeding. This study also provides new insights into the genetic mechanism of STB. - Source: PubMed
Publication date: 2024/01/08
Li CaijingLu ChangshengYang MengmengWu GuangliangNyasulu MvuyeniHe HaohuaHe XiaopengBian Jianmin - Testicular germ cell tumor (TGCT) is the most common cancer among young White men. TGCT is highly heritable, although there are no known high-penetrance predisposition genes. CHEK2 is associated with moderate TGCT risk. - Source: PubMed
Publication date: 2023/05/26
Pyle Louise CKim JungBradfield JonathanDamrauer Scott MD'Andrea KurtEinhorn Lawrence HGodse RamaHakonarson HakonKanetsky Peter AKember Rachel LJacobs Linda AMaxwell Kara NRader Daniel JVaughn David JWeathers BenitaWubbenhorst BradleyRegeneron Genetics Center Research Team Cancer Genomics Research Laboratory Greene Mark HNathanson Katherine LStewart Douglas R