Ask about this productRelated genes to: NOC3L antibody
- Gene:
- NOC3L NIH gene
- Name:
- NOC3 like DNA replication regulator
- Previous symbol:
- C10orf117
- Synonyms:
- AD24, FLJ12820, FAD24
- Chromosome:
- 10q23.33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-20
- Date modifiied:
- 2016-02-01
Related products to: NOC3L antibody
Related articles to: NOC3L antibody
- - Source: PubMed
Publication date: 2026/02/11
Rambaldelli GuglielmoManara ValeriaVutera Cuda AndreaBertalot GiovanniPenzo MariannaBellosta Paola - NOC1, NOC2 and NOC3 are evolutionarily conserved nucleolar proteins that play an essential role in the maturation and processing of ribosomal RNA (rRNA). NOC1 in Drosophila is necessary to sustain rRNA processing, whereas its depletion leads to impaired polysome formation, reduced protein synthesis and induces apoptosis. In this study, we demonstrated that the RNA-regulatory functions of NOC1 are conserved in vertebrates, where the reduction of CEBPZ, the homolog of NOC1, leads to the accumulation of unprocessed 45S pre-rRNA, a reduction in protein synthesis, and inhibition of cell growth. Gene Ontology and bioinformatic analyses of CEBPZ, NOC2L and NOC3L in tumors highlight a significant correlation between their expression and processes that regulate rRNA processing and ribosomal maturation. Moreover, comparative analysis of TCGA datasets from tumor databases revealed that CEBPZ, NOC2L and NOC3L exhibit contrasting expression patterns across tumor types. This context-dependent behavior suggests that overexpression of these proteins might promote tumor growth, whereas reduced expression could exert tumor-suppressive effects, underscoring their complex and unexpected regulatory roles in cancer. - Source: PubMed
Publication date: 2025/09/12
Rambaldelli GuglielmoManara ValeriaVutera Cuda AndreaBertalot GiovanniPenzo MariannaBellosta Paola - Aortic aneurysm (AA) is a genetic cardiovascular disease marked by progressive weakening and dilation of the aortic wall, often resulting in high mortality if untreated. Early diagnosis and prevention remain challenging. This study integrated genome-wide association studies (GWAS), proteome-wide Mendelian randomization (PW-MR), and single-cell RNA sequencing data from large-scale cohorts (FinnGen, deCODE Genetics, and UK Biobank Pharma Proteomics Project) to identify new biomarkers and therapeutic targets for AA. Analyzing genetic data from 8125 AA patients and 381,977 controls, we identified four significant loci (ADAMTS8, PLCE1, NOC3L, and SPSB1). PW-MR highlighted numerous plasma proteins, with interleukin-6 receptor (IL6R) showing strong association and colocalization in both deCODE and UK Biobank Pharma Proteomics Project (UKB-PPP) datasets. Multi-trait colocalization analysis supports IL6R's role, suggesting that drugs targeting IL6R, such as tocilizumab, may benefit AA treatment, though potential side effects warrant consideration. Single-cell analysis indicated that macrophages are crucial in AA progression, particularly through the IL6R-mediated inflammatory response. These findings emphasize IL6R as a potential target for early intervention and AA prevention. By integrating genetic associations, proteomic evidence, and single-cell insights, this study offers new strategies for identifying biomarkers, understanding disease mechanisms, and developing targeted therapies for aortic aneurysm. - Source: PubMed
Publication date: 2025/05/21
Bai ZihaoAn JiaHan JingruZhang YuxiWang HaoYang ZhaocongMo Xuming - Paternal exposure to drugs of abuse can impact addiction-related behaviours in progeny via germline epigenome remodelling. Previously, we found that offspring of morphine-exposed male rats showed increased morphine-taking, diminished adolescent social play, and increased sensitivity to morphine-derived analgesia. Here, we first tested the impact of a 90-day paternal abstinence period following morphine self-administration on the transmission of the aforementioned phenotypes. The previously observed changes in morphine-related behaviours were no longer present in offspring of morphine-abstinent sires. We next compared small RNA (smRNA) content in sperm collected from four sire intravenous self-administration groups: morphine, saline, abstinent morphine, and abstinent saline. Two smRNAs (rno-miR-150-5p and an snoRNA annotated to /) were differentially expressed specifically between morphine- and saline-treated sperm. No differential expression between abstinent morphine and saline sperm was observed. These data begin to delineate the temporal limits of heritable germline modifications associated with morphine exposure, in addition to identifying F0 germline factors coinciding with the manifestation of F1 multigenerational phenotypes. Furthermore, these data suggest that paternal abstinence at conception can prevent inheritance of germline factors that may alter offspring susceptibility to addiction-related endophenotypes. - Source: PubMed
Publication date: 2025/03/20
Zeid DanaToussaint Andre BDressler CarmenHarbeck AngelaKarbalaei RezaCintrón YandrésPan AndrewWimmer Mathieu - NOC1, NOC2, and NOC3 are evolutionarily conserved nucleolar proteins that play an essential role in the maturation and processing of ribosomal RNA (rRNA). NOC1, in is necessary to sustain rRNA processing, whereas its depletion leads to impaired polysome formation, reduced protein synthesis, and induces apoptosis. In this study, we demonstrated that the RNA-regulatory functions of NOC1 are conserved in vertebrates, where the reduction of the CEBPZ homolog of NOC1 leads to the accumulation of unprocessed 45S pre-rRNA, a reduction in protein synthesis, and inhibition of cell growth. Gene Ontology and bioinformatic analyses of CEBPZ, NOC2L, and NOC3L in tumors highlight a significant correlation between their expression and processes that regulate rRNA processing and ribosomal maturation. Moreover, comparative analysis of TCGA datasets from tumor databases revealed that CEBPZ, NOC2L, and NOC3L exhibit contrasting expression patterns across tumor types. This context-dependent behavior suggests that overexpression of these proteins may promote tumor growth, whereas reduced expression could exert tumor-suppressive effects, underscoring their complex and unexpected regulatory roles in cancer. - Source: PubMed
Publication date: 2025/04/23
Rambaldelli GuglielmoManara ValeriaVutera Cuda AndreaBertalot GiovanniPenzo MariannaBellosta Paola