Ask about this productRelated genes to: FBXO39 antibody
- Gene:
- FBXO39 NIH gene
- Name:
- F-box protein 39
- Previous symbol:
- -
- Synonyms:
- MGC35179, Fbx39, CT144
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-15
- Date modifiied:
- 2019-02-20
Related products to: FBXO39 antibody
Related articles to: FBXO39 antibody
- Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Ubiquitination modification is extensively involved in various biological processes, including aerobic glycolysis and tumor development. TP53 mutations are present in nearly half of CRC patients, while in p53-wild type CRC, effective therapeutic targets remain relatively limited. - Source: PubMed
Publication date: 2026/04/01
Liu JipengXiao TaifuHuang Jun - The SCF (Skp-Cullin-F-box) complex is a major class of E3 ubiquitin ligases. F-box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F-box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes. - Source: PubMed
Publication date: 2026/03/31
Kaneda YukiMiyata HaruhikoIkawa Masahito - The global decline in male fertility highlights the need to understand the mechanisms of spermatogenesis. Mitochondrial dysfunction and ferroptosis have emerged as key contributors to spermatogenic impairment, although the molecular basis of this process is still poorly defined. F-Box Protein 39 (FBXO39), a testis-enriched F-box protein, has been preliminarily associated with cell survival. However, whether FBXO39 participates in mitochondrial functional regulation or ferroptosis signaling during spermatogenesis remains largely unexplored. In our study, FBXO39 knockdown resulted in abnormal testicular development, impaired spermatogenesis, abnormal sperm morphology, and reduced testicular cell viability. Further analysis revealed that FBXO39 deficiency caused mitochondrial dysfunction and ferroptosis, as reflected by decreased ATP production, reduced mitochondrial DNA content, elevated eactive oxygen species (ROS) levels, diminished expression of key mitochondrial proteins, and elevated lipid peroxidation. Mechanistically, FBXO39 maintains mitochondrial homeostasis by targeting lysine-specific demethylase 5A (KDM5A) for ubiquitination-dependent degradation. Conversely, the accumulation of KDM5A upon FBXO39 loss suppressed single-stranded DNA-binding protein 1 (SSBP1) levels through demethylation of Histone H3 lysine 4 trimethylation (H3K4me3) at the SSBP1 promoter. Importantly, restoration of SSBP1 expression functionally ameliorated mitochondrial dysfunction induced by FBXO39 knockdown. Overall, FBXO39 regulates mitochondrial function and ferroptosis in testicular cells through ubiquitinating KDM5A, which affects SSBP1 expression by modulating H3K4me3 demethylation at the SSBP1 promoter. This study elucidates the role of FBXO39 in spermatogenesis and suggested that targeting this regulatory axis may offer novel therapeutic strategies for male infertility. - Source: PubMed
Publication date: 2026/03/04
Li TaoWang KunChen YuxiangLi ZhuochengLi ShandaZhang YuZhu XuyuanShi HaoranGao LiangJiang Hongtao - This study aimed to identify cytotoxic T lymphocyte (CTL)-specific epitopes from three tumor-associated antigens (TAAs)-Dickkopf-like 1 (DKKL1), F-box protein 39 (FBXO39), and Opa-interacting protein 5 (OIP5)-which are overexpressed in colorectal cancer (CRC), as potential candidates for CTL-mediated immunotherapy. - Source: PubMed
Publication date: 2025/06/17
Sun PeiweiWang LuolinLiu ZhongXu Zhenglei - Glioblastoma multiform (GBM) is a primary brain malignancy resistant to conventional therapies, with poor survival. Cancer testis antigens (CTAs) are important cancer diagnostic biomarkers and therapeutic targets. Bioinformatics analysis of GBM clinical and molecular data was undertaken to identify and validate the key CTA genes, whose expression correlates with the survival of GBM patients. - Source: PubMed
Publication date: 2025/06/12
Azimi ParisaBazrgar MaryamYazdanian TaravatTotonchi MehdiAhmadiani Abolhassan