Ask about this productRelated genes to: RWDD4A antibody
- Gene:
- RWDD4 NIH gene
- Name:
- RWD domain containing 4
- Previous symbol:
- FAM28A, RWDD4A
- Synonyms:
- MGC10198
- Chromosome:
- 4q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-10-04
- Date modifiied:
- 2015-09-09
Related products to: RWDD4A antibody
Related articles to: RWDD4A antibody
- Long noncoding RNAs (lncRNA) exert essential functions during tumorigenesis. However, how lncRNAs participate in glioma development remains poorly researched. This study aimed to determine how DDX11-AS1 affects glioma progression. - Source: PubMed
Publication date: 2021/01/08
Zheng YanyanXie JingXu XiaominYang XiaoguoZhou YiYao QiongXiong Ye - The aim of this study was to identify the key differentially expressed genes (DEGs) and high-risk gene mutations in breast ductal carcinoma in situ (DCIS). - Source: PubMed
Publication date: 2020/03/10
Zhu CongyuanHu HaoLi JianpingWang JingliWang KeSun Jingqiu - MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell proliferation, migration and invasion. Additionally, upregulated miR-506 increased E-cadherin, and reduced N-cadherin and Vimentin expression levels, as markers of epithelial-to-mesenchymal transition. RWD domain containing 4 (RWDD4) was revealed to be a miR506 target in BCa cells, and the downregulation of RWDD4 was found to suppress BCa cell proliferation, migration and invasion. In summary, miR-506 may suppress the aggressive properties of human BCa cells by targeting RWDD4, and thus may be a novel therapeutic target in human BCa. - Source: PubMed
Publication date: 2018/10/18
Hou Yi - It is unclear how standing genetic variation affects the prognosis of prostate cancer patients. To provide one controlled answer to this problem, we crossed a dominant, penetrant mouse model of prostate cancer to Diversity Outbred mice, a collection of animals that carries over 40 million SNPs. Integration of disease phenotype and SNP variation data in 493 F1 males identified a metastasis modifier locus on Chromosome 8 (LOD = 8.42); further analysis identified the genes Rwdd4, Cenpu, and Casp3 as functional effectors of this locus. Accordingly, analysis of over 5,300 prostate cancer patient samples revealed correlations between the presence of genetic variants at these loci, their expression levels, cancer aggressiveness, and patient survival. We also observed that ectopic overexpression of RWDD4 and CENPU increased the aggressiveness of two human prostate cancer cell lines. In aggregate, our approach demonstrates how well-characterized genetic variation in mice can be harnessed in conjunction with systems genetics approaches to identify and characterize germline modifiers of human disease processes. - Source: PubMed
Publication date: 2016/12/01
Winter Jean MGildea Derek EAndreas Jonathan PGatti Daniel MWilliams Kendra ALee MinnkyongHu YingZhang Suiyuan Mullikin James CWolfsberg Tyra GMcDonnell Shannon KFogarty Zachary CLarson Melissa CFrench Amy JSchaid Daniel JThibodeau Stephen NChurchill Gary ACrawford Nigel P S