Ask about this productRelated genes to: FAM76B antibody
- Gene:
- FAM76B NIH gene
- Name:
- family with sequence similarity 76 member B
- Previous symbol:
- -
- Synonyms:
- MGC33371
- Chromosome:
- 11q21
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-15
- Date modifiied:
- 2017-11-28
Related products to: FAM76B antibody
Related articles to: FAM76B antibody
- Oncogenic fusions of with , , , and retain the transactivating domain (TAD) and are believed to drive aberrant gene transcription. While the oncogenic roles of these known fusions have been established, we aimed to identify novel fusions across a range of human malignancies. - Source: PubMed
Publication date: 2025/09/27
Komiya TakefumiSweeney KieranHuang Chao HCrymes AnthonyAntonarakis Emmanuel SElliott AndrewOberley Matthew JEvans Mark G - Osteosarcoma (OS), a prevalent malignancy primarily in young individuals, often evades T cell based immunotherapy due to an immunosuppressive myeloid cell-mediated microenvironment. This study investigated the role of FAM76B in OS and its impact on macrophage polarization and tumor immune response. - Source: PubMed
Publication date: 2025/08/05
Zhou TianshengYang XiangyuZhao DingTan XiaoqianLiu YingqiLi TianZhu Guanghui - Intermittent hypoxia (IH), as a key pathogenic factor of obstructive sleep apnea syndrome (OSAS), can cause many diseases, such as increased inflammation and oxidative stress, diabetes, cardiovascular disease, and Alzheimer's disease (AD). The response of cells to hypoxia involves multiple levels of regulatory mechanisms, including transcriptional regulation of gene expression, regulation of mRNA stability, post-transcriptional regulation, and post-translational modification regulation. - Source: PubMed
Liu ChunchengQu DonghuiLi ChaoxunPu WenhuaLi JunCai Lu - Ewing sarcoma (EwS) is a highly malignant and heterogeneous tumor. Exploring clinicopathological characteristics and genetic features of EwS is critical for prognosis and treatment regimen. - Source: PubMed
Publication date: 2024/09/16
Li JialiJi Yuan - Macrophage polarization is closely related to inflammation development, yet how macrophages are polarized remains unclear. In our study, the number of M1 macrophages was markedly increased in Fam76b knockout U937 cells vs. wild-type U937 cells, and FAM76B expression was decreased in M1 macrophages induced from different sources of macrophages. Moreover, Fam76b knockout enhanced the mRNA and protein levels of M1 macrophage-associated marker genes. These results suggest that FAM76B inhibits M1 macrophage polarization. We then further explored the mechanism by which FAM76B regulates macrophage polarization. We found that FAM76B can regulate PI3K/Akt/NF-κB pathway-mediated M1 macrophage polarization by stabilizing PIK3CD mRNA. Finally, FAM76B was proven to protect against inflammatory bowel disease (IBD) by inhibiting M1 macrophage polarization through the PI3K/Akt/NF-κB pathway in vivo. In summary, FAM76B regulates M1 macrophage polarization through the PI3K/Akt/NF-κB pathway in vitro and in vivo, which may inform the development of future therapeutic strategies for IBD and other inflammatory diseases. - Source: PubMed
Publication date: 2024/02/29
Wang JuanZhao XinyueWang QizhiZheng XiaojingSimayi DilihumaerZhao JunliYang PeiyanMao QinwenXia Haibin