Ask about this productRelated genes to: TTC12 antibody
- Gene:
- TTC12 NIH gene
- Name:
- tetratricopeptide repeat domain 12
- Previous symbol:
- -
- Synonyms:
- FLJ13859, FLJ20535, TPARM
- Chromosome:
- 11q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-02
- Date modifiied:
- 2015-08-26
Related products to: TTC12 antibody
Related articles to: TTC12 antibody
- Little is known regarding the shared genetic architecture underlying the phenotypic associations between depression and preterm birth (PTB). We aim to investigate the genetic overlap and causality of depression with PTB. - Source: PubMed
Publication date: 2025/09/25
Zhang MinChen XinzhenZhou WenzhengZhou NiyaZhang CuihuaYang YunpingLi QiyinMing XinWu YifuQi HongboZhou Wei
- Source: PubMed
- Problematic alcohol use (PAU) adversely affects the clinical course of psychiatric disorders. Genetic studies have suggested that genetic factors underlie the co-occurrence of PAU with psychiatric disorders. This study aimed to elucidate shared genetic architectures, prioritizing genes that disorders may have in common. - Source: PubMed
Publication date: 2025/05/07
Ahn YeeunKim JaehyunJung KyeongminLee Dong JuneJung Jin YoungEom YewonPark SanghyeonKim JaeyoungKim HyejinJo HyeonbinHong SanghoonO'Connell Kevin SAndreassen Ole AMyung WoojaeWon Hong-Hee - Degenerative cervical myelopathy (DCM) is a progressive spinal condition that can lead to severe neurological dysfunction. Despite its degenerative pathophysiology, family history has shown to be a largely important factor in incidence and progression, suggesting that inherent genetic predisposition may play a role in pathophysiology. - Source: PubMed
Publication date: 2024/11/02
Seah CarinaKarabacak MertMargetis Konstantinos - Obesity is a risk factor for increased morbidity and mortality in viral respiratory infection. Mucociliary clearance (MCC) in the airway is the primary host defense against viral infections. However, the impact of obesity on MCC is unclear, prompting this study. Using murine tracheal tissue culture and in vitro influenza A virus (IAV) infection models, we analyzed cilia-driven flow and ciliary beat frequency (CBF) in the airway epithelium to evaluate MCC. Short-term IAV infection increased cilia-driven flow and CBF in control mice, but not in high-fat diet-induced obese mice. Basal cilia-driven flow and CBF were also lower in obese mice than in control mice. Mechanistically, the increase of extracellular adenosine triphosphate (ATP) release during IAV infection, which was observed in the control mice, was abolished in the obese mice; however, the addition of ATP increased cilia-driven flow and CBF both in control and obese mice to a similar extent. In addition, RNA sequencing and reverse transcription-polymerase chain reaction revealed the downregulation of several cilia-related genes, including , , and (the dynein-related genes); (the polychaete differentiation gene); (the ciliogenesis and intraflagellar transport gene); , , and (the radial spoke structure and assembly gene); and (the nexin-dynein regulatory complex genes) in obese murine tracheal tissues compared with their control levels. In conclusion, our studies demonstrate that obesity attenuates MCC under basal conditions and during IAV infection by downregulating the expression of cilia-related genes and suppressing the release of extracellular ATP, thereby increasing the susceptibility and severity of IAV infection. Our study shows that obesity impairs airway mucociliary clearance (MCC), an essential physical innate defense mechanism for viral infection. Mechanically, this is likely due to the obesity-induced downregulation of cilia-related genes and attenuation of extracellular ATP release. This study provides novel insights into the mechanisms driving the higher susceptibility and severity of viral respiratory infections in individuals with obesity. - Source: PubMed
Publication date: 2024/08/06
Tanaka YukoFujisawa TomoyukiYazawa ShusukeOhta IsaoTakaku YasuharuIto MasahikoInoue YusukeYasui HidekiHozumi HironaoKarayama MasatoSuzuki YuzoFuruhashi KazukiEnomoto NoriyukiSetou MitsutoshiInui NaokiSuzuki TetsuroSuda Takafumi