Ask about this productRelated genes to: PELI3 antibody
- Gene:
- PELI3 NIH gene
- Name:
- pellino E3 ubiquitin protein ligase family member 3
- Previous symbol:
- -
- Synonyms:
- MGC35521
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-16
- Date modifiied:
- 2014-11-19
Related products to: PELI3 antibody
Related articles to: PELI3 antibody
- M2 macrophage-to-myofibroblast transformation (MMT) contributes to fibrosis. The role of interferon regulatory factor 4 (IRF4), a key transcription factor in M2 macrophage polarization, in M2 MMT remains unclear. This study aimed to elucidate the role of IRF4 in M2 MMT. - Source: PubMed
Publication date: 2026/04/22
Zhu JinglinZhao FangningZeng Gao - Tumor necrosis factor receptor 1-associated death domain protein (TRADD) can trigger proapoptotic autophagy in non-small cell lung cancer (NSCLC). While the potential ubiquitin-protein ligase (E3) against TRADD is not well deciphered. - Source: PubMed
Publication date: 2026/01/09
Li FannianLi XiaoningLi HaitaoLi ShuaiLiu YanchaoBai XianhuaQi TianjieZhao XiuminHe Yuzheng - Radiotherapy remains a cornerstone of treatment for non-small cell lung cancer (NSCLC). Despite its critical role, the emergence of radiation resistance remains a significant hurdle, often leading to therapeutic failure and disease progression. This research aimed to investigate the expression of Pellino E3 ubiquitin protein ligase family member 3 (PELI3) in NSCLC and examine its involvement in modulating the tumor's response to radiation. - Source: PubMed
Publication date: 2026/01/08
Li FannianLi XiaoningLi HaitaoLi ShuaiLiu YanchaoBai XianhuaQi TianjieZhao XiuminHe Yuzheng - Understanding the genetic mechanism of cold adaptation in cashmere goats and dairy goats is very important to improve their production performance. The purpose of this study was to comprehensively analyze the genetic basis of goat adaptation to cold environments, clarify the impact of environmental factors on genome diversity, and lay the foundation for breeding goat breeds to adapt to climate change. A total of 240 dairy goats were subjected to genome resequencing, and the whole genome sequencing data of 57 individuals from 6 published breeds were incorporated. By integrating multiple approaches such as phylogenetic analysis, population structure analysis, gene flow and population history exploration, selection signal analysis, and genome-environment association analysis, an in-depth investigation was carried out. Phylogenetic analysis unraveled the genetic relationships and differentiation patterns among dairy goats and other goat breeds. Through signal analysis (θπ, FST, XP-CLR), we identified numerous candidate genes associated with cold adaptation in dairy goats (STRIP1, ALX3, HTR4, NTRK2, MRPL11, PELI3, DPP3, BBS1) and cashmere goats (MED12L, MARC2, MARC1, DSG3, C6H4orf22, CHD7, MYPN, KIAA0825, MITF). Genome-environment association (GEA) analysis confirmed the link between these genes and environmental factors. Moreover, a detailed analysis of the critical genes C6H4orf22 and STRIP1 demonstrated their significant roles in the geographical variations of cold adaptation and allele frequency differences among different breeds. This study contributes to understanding the genetic basis of cold adaptation, providing crucial theoretical support for precision breeding programs aimed at improving production performance in cold regions by leveraging adaptive alleles, thereby ensuring sustainable animal husbandry. - Source: PubMed
Publication date: 2025/09/09
Zhao JianqingYao WeiweiLiu QingqingGong PingMu YuanpanWang WeiLiu BaolongLi CongShi HengboLuo Jun - This study aims to explore the causal relationship between programmed cell death (PCD) genes and the formation of hypertrophic scars (HS) using integrative multi-omics analysis (including DNA methylation, gene expression, and protein abundance) alongside preliminary experimental validation. - Source: PubMed
Publication date: 2025/08/19
Zhang YushenZhao ChenyuyaoZhao Ran