Ask about this productRelated genes to: HMBS antibody
- Gene:
- HMBS NIH gene
- Name:
- hydroxymethylbilane synthase
- Previous symbol:
- PBGD, UPS, PORC
- Synonyms:
- -
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: HMBS antibody
Related articles to: HMBS antibody
- In 2023, international consensus recommendations suggested the use of prolonged-infusion beta-lactam antibiotics over short-infusion dosing in severely ill adult patients to improve mortality or clinical cure, although the certainty of evidence was very low. With the availability of several new randomized controlled trials (RCTs), this focused update re-evaluates the efficacy of prolonged versus short infusion among severely ill adult patients. The original Population, Intervention, Comparator, and Outcome (PICO) question VII was separated into two questions addressing mortality (VIIa) and clinical cure (VIIb). Methods used for study identification, screening, and evidence grading were consistent with the original guideline, with the addition of Bayesian meta-analyses. A total of 28 RCTs evaluating mortality in severely ill adults were analyzed, with pooled estimates favoring prolonged infusion (RR 0.91; 95% confidence interval 0.85 to 0.97), supported by Bayesian analyses demonstrating a 98.76% posterior probability of benefit. Across 21 RCTs evaluating clinical cure, prolonged infusion improved outcomes compared with short infusion (RR 1.11; 95% confidence interval 1.06 to 1.17), supported by Bayesian analyses demonstrating a 99.97% posterior probability of benefit. Certainty of evidence was strengthened to moderate for mortality and low for clinical cure. Consistent with the original recommendation (PICO X), subgroup analyses evaluating loading doses suggested improved outcomes when a loading dose is used before continuous infusion. Overall, the cumulative evidence reinforces and strengthens the recommendation for use of prolonged-infusion beta-lactam therapy in severely ill adult patients to improve survival and clinical cure. Continued use of loading doses when initiating continuous-infusion therapy is suggested. Future research should identify subpopulations most likely to benefit, clarify optimal prolonged-infusion strategies, and define the role of therapeutic drug monitoring. - Source: PubMed
Hong Lisa TFakhriRavari AlirezaUlldemolins MartaRoberts Jason ABonomo Robert AScheetz Marc H - Human milk banks (HMBs) are an essential clinical service, providing safe, screened donor human milk (DHM) to clinically vulnerable infants, which can enable mothers to establish their own milk supply. While HMB processes share similarities with other medical products of human origin (e.g., blood, platelets), HMBs remain marginalised services with limited resilience to external or internal pressures. As demand for DHM increases, understanding how to mitigate these vulnerabilities is essential. In November 2022, a workshop organised by the Human Milk Foundation brought together UK milk bank leaders, academics, and planners. The workshop aimed to understand existing pressures faced by UK HMBs and create a network to support strategic, evidence-based responses. Emergent themes highlighted that HMBs are stretched, facilitated largely by goodwill. Most services are reliant on limited workforces with limitations in service continuity, training, and succession planning. COVID-19 exacerbated pressures, but led to HMBs cooperating more. Proposed responses included investment in staffing, training and IT resources, greater public awareness and inter-HMB cooperation, and a national HMB Risk Register. Service continuity needs to be urgently addressed through external multiagency engagement, operational support, and research prioritization (including qualitative, technological and implementation science), defining optimal service design and financial resourcing to meet nationally agreed needs. Without intervention, the UK milk bank network may be unable to respond to future significant pressures, including specialist infant feed or infant formula shortages. With appropriate investment, a comprehensive National Service can be created to provide equitable services underpinned by robust research and innovation. - Source: PubMed
Publication date: 2026/08/12
Shenker NatalieHatia AminaGriffin SamanthaChandler-Maini GemmaBailie LizBarnett DebbieSavage EmmaD'Souza AliceDowling CarmelGane TaniaStroud SusanWood AmandaHolder GemmaCrawley HelenSibson VickyGray HelenFallon NaomiBrackley MelissaHinds HelenTurner HelenHogan MattKemp DebbieKennedy AileenKerac MarkoMeeajan RehanaMistry HemaO'Sullivan LizPatton ClareStaff MartaZuber LauraThomson MerranShariff AsmaaPsaila VikkiGreen AmandaWatt JoPartridge GemmaCrombie TinaWebster FlicCameron SimonCheema SimranBrown AmyWeaver GillianEasthope Lucy - Ceftaroline and ceftobiprole are fifth-generation cephalosporins with activity against methicillin-resistant Staphylococcus aureus. Like other β-lactam antimicrobials, their efficacy correlates with the percentage of the dosing interval during which unbound drug concentrations exceed the minimum inhibitory concentration (MIC) of the pathogen (% fT). However, achieving optimal exposures may be challenging in patients with altered pharmacokinetics or deep-seated infections. - Source: PubMed
Publication date: 2026/08/10
Genovese CamillaColaneri MartaSguazzini EnricoMaddalena DonatellaAbdul-Aziz Mohd-HafizSime Fekade BSoriano AlexGori AndreaRoberts Jason AUlldemolins Marta - Estimating time since death, or Post-Mortem Interval (PMI), is a critical component of forensic veterinary pathology. Although many variables are implicated in the decomposition timescale, environmental temperature and its fluctuations significantly affect its progression and the accuracy of PMI estimates. Accumulated Degree Days (ADDs) assist in PMI determination by summing the daily average environmental temperatures. Biomolecular techniques, especially RNA-based analysis, offer promising applications due to the intrinsic instability of RNA after death. In this study, 54 deceased cats collected from veterinary clinics underwent post-mortem (PM) liver sampling. It was performed in 48 cats after exposure to either an outdoor environment ("in field") or stored at + 4 °C ("refrigerated") for 1, 3, 14 and 28 days (6 cats each time point). The remaining 6 cats were sampled within 1 h of death ("controls"). ADDs were subsequently calculated. Microfluidic electrophoresis was performed on RNA extracts from liver samples, obtaining RNA Integrity Number (RIN) and DV (percentage of RNA fragments above 200 nucleotides) values. The degradation of target reference gene mRNAs (RPL17, GAPDH, HMBS) was evaluated using qPCR and ddPCR. A statistically significant reduction (p < 0.05) of RIN, DV and RPL17-mRNA levels was observed in "in field" cats within the 51-200 ADDs range, compared to controls. In the "refrigerated" cats, similar degradation patterns were found between 14- and 28-day cats compared to controls (RIN, DV, and qPCR results on GAPDH-mRNA, p < 0.01). RIN and DV appear to be promising parameters for PMI estimation in cats, particularly for distinguishing recent deaths from those exceeding 50 ADDs. - Source: PubMed
Publication date: 2026/08/09
Botta LucaDivari SaraPregel PaolaRicci EmanueleRessel LorenzoScaglione Frine Eleonora - Critically ill patients exhibit altered pharmacokinetics, rendering antibiotic dosing challenging. Achieving therapeutic antibiotic exposures may be improved with the use of precision dosing software programs. - Source: PubMed
Williams PaulCotta Menino OsbertWilks KathrynFarkas AndrasSpelman TimRoberts Jason A