Ask about this productRelated genes to: VPS37C antibody
- Gene:
- VPS37C NIH gene
- Name:
- VPS37C subunit of ESCRT-I
- Previous symbol:
- -
- Synonyms:
- FLJ20847
- Chromosome:
- 11q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-17
- Date modifiied:
- 2019-01-31
Related products to: VPS37C antibody
Related articles to: VPS37C antibody
- We aimed to explore the global and sex-specific genetic variants associated with long COVID, as defined by patient-driven symptom recall. A 1-year cohort study of 2411 COVID-19 patients collected long COVID symptoms with an open-ended, non-directed questionnaire, and long COVID incidence was determined according to the World Health Organization definition. Global and sex-stratified genome-wide association analyses were conducted by logistic regression models adjusted for age, sex (in the global analysis), and the first 10 principal components. We assessed sex-variant interactions and performed gene-based analyses, gene mapping, and gene-set enrichment analyses. When comparing the 1392 long COVID cases with the non-cases, we identified 23 lead variants from suggestive signals: 13 from the global analysis, 5 from females, and 5 from males. Five variants showed a significant interaction with sex (two in females, three in males). We mapped 15 protein-coding genes related to diseases of the immune and nervous systems and tumoral processes. Notably, CD5 and VPS37C, linked to immune function, were significantly associated with long COVID in men. Our results suggest that persistent immune dysregulation may be involved in the development of precisely defined long COVID. - Source: PubMed
Publication date: 2025/09/22
Polo-Alonso SaraHernáez ÁlvaroDégano Irene RMartí-Lluch RuthPinsach-Abuin Mel LinaElosua RobertoSubirana IsaacPuigmulé MartaPérez AlexandraCruz RaquelDiz-de Almeida SilviaPuigdecant EulàliaSelga ElisabetNogues XavierMasclans Joan RamonGüerri-Fernández RobertoCubero-Gallego HéctorTizon-Marcos HelenaVaquerizo BeatrizBrugada RamonRamos RafelCamps-Vilaró AnnaMarrugat Jaume - Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a heterogeneous condition characterised by chronic gastrointestinal inflammation and dysregulated immune responses. Despite advances in transcriptomic analysis and machine learning (ML), consistent molecular subtyping across datasets remains a challenge. There is a critical need for robust subtypes that reflect disease heterogeneity and correlate with clinical outcomes. - Source: PubMed
Publication date: 2025/08/12
Saini NiyatiAcharjee Animesh - Previous studies have reported that exosomes produced by corneal stromal cells from keratoconus patients exhibit a molecular content distinct from those produced by cells from healthy donors. This study investigates differences in the expression of ESCRT components, regarded as the most critical mechanism in exosome biogenesis. The study included analysis of transcription levels of system-encoding genes using qRT-PCR reactions, as well as semiquantitative protein determination through immunocytochemistry. Of the 34 molecules analyzed, mRNA downregulation was observed in 8 in pathological cells. In keratoconus, genes encoding STAM2 from the ESCRT-0 complex and VPS37A, VPS37C, VPS37D and UBAP1 from the ESCRT-I complex were found to be underexpressed, although VPS37D could not be confirmed at the protein level. Additionally, two other expression alterations affected the ESCRT-III complex, involving the core protein CHMP4C and the regulatory protein CHMP1B. Finally, deregulation of the ubiquitin-specific peptidase UBPY was observed. Most changes identified in this study affected specific isoforms, which could suggest functional diversification and differences in cargo recognition in the context of pathology. Altogether, these findings suggest that the previously reported alteration in the molecular content of exosomes produced by stromal cells in keratoconus may be, at least partially, due to disruptions in the exosome synthesis machinery. - Source: PubMed
Publication date: 2025/01/30
Blanco-Agudín NoeliaYe SuhuiAlcalde IgnacioCorte-Torres María DanielaGalarreta DavidCaro-Magdaleno ManuelFernández-Vega IvánFernández-Vega Cueto LuisMerayo-Lloves JesúsQuirós Luis M - Identifying target proteins for bioactive molecules is essential for understanding their mechanisms, developing improved derivatives, and minimizing off-target effects. Despite advances in target identification (target-ID) technologies, significant challenges remain, impeding drug development. Most target-ID methods use cell lysates, but maintaining an intact cellular context is vital for capturing specific drug-protein interactions, such as those with transient protein complexes and membrane-associated proteins. To address these limitations, we developed POST-IT (Pup-On-target for Small molecule Target Identification Technology), a non-diffusive proximity tagging system for live cells, orthogonal to the eukaryotic system. POST-IT utilizes an engineered fusion of proteasomal accessory factor A and HaloTag to transfer Pup to proximal proteins upon directly binding to the small molecule. After significant optimization to eliminate self-pupylation and polypupylation, minimize depupylation, and optimize chemical linkers, POST-IT successfully identified known targets and discovered a new binder, SEPHS2, for dasatinib, and VPS37C as a new target for hydroxychloroquine, enhancing our understanding these drugs' mechanisms of action. Furthermore, we demonstrated the application of POST-IT in live zebrafish embryos, highlighting its potential for broad biological research and drug development. - Source: PubMed
Publication date: 2024/12/27
Sun YingjieLi ChanghengDeng XiaofeiLi WenjieDeng XiaoyiGe WeiqiShi MiaoyuanGuo YingYu Yanxun VZhou Hai-BingJin Youngnam N - Abdominal aortic aneurysms (AAAs) are focal dilatations of the abdominal aorta that expand progressively, increasing their risk of rupture. Rupture of an AAA is associated with high mortality rates, but the mechanisms underlying the initiation, expansion, and rupture of AAAs are not yet fully understood. We aimed to characterize the pathophysiology of AAAs and identify new genes associated with AAA initiation and progression. - Source: PubMed
Publication date: 2024/12/10
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