Ask about this productRelated genes to: FANCA antibody
- Gene:
- FANCA NIH gene
- Name:
- FA complementation group A
- Previous symbol:
- FACA, FANCH
- Synonyms:
- FAA, FA-H, FAH
- Chromosome:
- 16q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-12-22
- Date modifiied:
- 2019-04-23
Related products to: FANCA antibody
Related articles to: FANCA antibody
- Folate metabolites are chemically unstable: spontaneous decomposition releases formaldehyde, a genotoxin in blood stem cells and a human carcinogen. Despite this, folic acid consumption frequently exceeds the Recommended Dietary Allowance and is prescribed at high doses for patients with blood disorders. However, the impact of excess folate on endogenous formaldehyde genotoxicity in vivo has not been studied. We find that excess tetrahydrofolate (THF) treatment of cell lines elevates formaldehyde-DNA adducts and genotoxicity. To test this in vivo, we fed a high-folic acid diet (10-fold above standard) to mice with heightened sensitivity to formaldehyde: detoxification-impaired Adh5 mice, and Fanconi anemia DNA repair mutants Fanca and Fancj. In contrast to cell lines, elevated tissue THF was not associated with increased formaldehyde-DNA adducts nor blood stem cell attrition. Finally, in cancer patients, high-dose folic acid therapy elevated plasma folic acid but did not increase formaldehyde-DNA adducts in peripheral blood mononuclear cells. In conclusion, increased folate in vivo does not elevate endogenous formaldehyde genotoxicity in sensitized mouse models or humans. - Source: PubMed
Publication date: 2026/08/12
Mellor ChristopherJames Brandon TAzad SaeidehKosmeder Emma PPurello Chloe TSingh MonikaSimon VictoriaCheng Nicholas WNiedermaier JessicaBurgos-Barragan GuillermoBlenis John OMato Anthony RField Martha SWang Meng - To investigate the gene mutations in tumor tissues of patients with primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL), and analyze its relationship with clinical features and prognosis. - Source: PubMed
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Publication date: 2026/07/24
Dell'Elice AnastasiaPalmarini ClaudiaAnaclerio FedericoPilenzi LucreziaCalabrese GiuseppePalka ChiaraTinari NicolaGrassadonia AntoninoBallerini PatriziaGrossi SimonaVitali MarcoSecondi LorenzoAmerio PaoloGatta ValentinaStuppia LiborioAntonucci Ivana - This phase 2 trial investigated rucaparib (PARP inhibitor) in combination with nivolumab in patients with advanced BTC without progression after 4-6 months of first-line platinum-based chemotherapy. - Source: PubMed
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Mohan ArathiGriffith Kent AGoff Laura WCrysler OxanaEnzler ThomasCardin Dana BGunchick ValerieTsang Ashley PDippman DominiqueYoung Allison SOlivei Alberto CMannan RahulRao ArvindFrankel Timothy LKumar-Sinha ChandanZalupski Mark MSahai Vaibhav - The carcinogenesis of metastatic prostate cancer results from complex interactions between genetic and environmental factors. The genomic profiles of admixed populations, such as Brazilians, are still poorly explored, offering an opportunity to better understand the contribution of germline and somatic variants in these patients. - Source: PubMed
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