Ask about this productRelated genes to: MYL3 antibody
- Gene:
- MYL3 NIH gene
- Name:
- myosin light chain 3
- Previous symbol:
- -
- Synonyms:
- CMH8, VLC1, MLC1V, MLC1SB
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: MYL3 antibody
Related articles to: MYL3 antibody
- Feed scarcity constrains livestock production, particularly on the Qinghai-Tibet Plateau. The effects of green alfalfa (GA) on Diqing Tibetan pig performance remain unclear. This study aimed to evaluate GA effects on Diqing Tibetan pig performance and to explore the potential underlying mechanisms through integrated metagenomic, transcriptomic, and metabolomic analyses. Thirty-six Diqing Tibetan pigs were randomly assigned to two groups and fed either a basal diet or a diet containing 90% basal diet and 10% GA. GA did not adversely affect growth performance but reduced 6-7 rib backfat thickness and muscle water loss rate by 19.79% (FDR = 0.027) and 17.80% (FDR = 0.036), while increasing muscle moisture content by 3.51% (FDR = 0.036). GA increased cecal microbial alpha diversity, Bacteroidota-related taxa, and functional genes related to lipid and vitamin metabolism, while decreasing Bacillota and . In the longissimus dorsi, , and were upregulated, whereas and were downregulated; GA increased vanillyl alcohol, L-histidine, LPE (0:0/22:5), and licochalcone B, but decreased glyceryl monostearate, benzaldehyde, cortisol, tryptamine, 4-ethyloctanoic acid, 8-methylnonanoic acid, and purine. Overall, 10% GA reshaped gut microbial, muscle transcriptomic, metabolomic profiles and collectively influenced 6-7 rib backfat thickness and muscle water-holding capacity in Diqing Tibetan pigs. - Source: PubMed
Publication date: 2026/07/17
Huang HeteLi XinpengZhang KangLiang BingkunBai SiyaDong XinxingYan Dawei - Apolipoprotein A-IV (apoA-IV) plays key roles in lipid metabolism, reverse cholesterol transport, and kidney function, yet its genetic determinants remain poorly defined. We conduct a genome-wide association study (GWAS) meta-analysis of apoA-IV concentrations measured by ELISA in 25,181 individuals and combine these with proteomic data from 33,995 UK Biobank participants (Olink platform), yielding a total sample of 59,176. We perform genetic correlations and colocalization analyses to explore links with lipid, renal, and other complex traits. - Source: PubMed
Publication date: 2026/07/14
Koller AdrianaSchnitzer FlorianKollerits BarbaraLamina ClaudiaMoix SamuelClaringbould AnniqueMishra Binisha HLu HaojieSchachtl-Riess Johanna FForer LukasGieger ChristianKheirkhah AzinLehtimäki TerhoMarques-Vidal PedroSchönherr SebastianStark Klaus JWürzner ReinhardEckardt Kai-UweHeid Iris MKavousi MaryamKöttgen AnnaRaitakari OlliSijbrands Eric J GPeters AnnetteVollenweider PeterKronenberg Florian - Hypertrophic cardiomyopathy (HCM) variants in genes encoding the myosin heavy chain (MHC) (), myosin light chains ( and ), and cardiac myosin binding protein-C (cMyBP-C, ) lead to cardiac hypertrophy, with abnormal contractility, relaxation, and energy consumption. Here, we defined the structural consequences of pathogenic and benign missense variants in these genes by mapping 233 variants (, n = 175; , n = 41; , n = 12; , n = 5) onto a cryo-EM-based atomic model of the human cardiac thick filament. We identified HCM variants residing in 30 molecular interfaces of the complex thick filament interactome, including the two main interfaces of the myosin interacting-heads motif (IHM), and interfaces involving the MHC, essential and regulatory light chains, and cMyBP-C. None of the 21 variants classified as benign were within interfaces. We demonstrated earlier disease onset and adverse outcomes in HCM patients with pathogenic variants within vs. outside of molecular interfaces, emphasizing their importance in normal thick filament function and improving risk stratification of patients. - Source: PubMed
Publication date: 2026/06/29
Dutta DebabrataKim YuriHo Carolyn YSeidman Jonathan GSeidman Christine ECraig RogerPadrón Raúl - Although the Kazakh horse is a dual-purpose breed renowned for both milk and meat production, the extent to which surgical castration alters gene expression in its muscles has not yet been fully elucidated. In this study, left longissimus dorsi muscle (LDM) samples were obtained from six Kazakh stallions (W group) and six Kazakh geldings (S group) to comparatively evaluate meat quality parameters, examine histological characteristics in tissue sections, and apply transcriptomic profiling to comprehensively explore the principal regulatory pathways and candidate genes through which surgical castration modulates LDM growth. The results demonstrated that surgical castration did not induce significant alterations in meat color or pH-related parameters. However, cooking loss and shear force values were markedly diminished, accompanied by a marked decrease in muscle fiber cross-sectional area. Transcriptomic analysis identified 848 differentially expressed genes (DEGs) in total, comprising 415 upregulated and 433 markedly downregulated DEGs, which were predominantly enriched in key biological pathways, including actin cytoskeleton regulation. Moreover, eleven core candidate genes, including MYL2, MYL3, and TNNI1, were further screened and identified. - Source: PubMed
Publication date: 2026/06/18
Li ZexuRen WanluWang RanLi LulingMa ShikunSu YiShan DehaxiHuang QiupingWang Jianwen - This study aimed to clarify the molecular mechanisms of muscle growth/development in Liaoning cashmere goats and intestinal flora's regulatory role to improve meat production. Muscle tissues (intercostal, hindlimb biceps femoris, longissimus dorsi) and digestive contents (rumen, small intestine, cecum, feces) from goats at 6, 12, 18 months were analyzed via transcriptomics, proteomics, metabolomics, 16S rRNA sequencing, and multi-omics integration. Results: hindlimb biceps femoris optimally developed at 12 months (significantly associated with jejunal g_Lachnospiraceae_NK3A20_group, HOXC10, MYL3, cAMP pathway); longissimus dorsi actively grew at 12 months (closely related to ruminal/cecal g_Christensenellaceae_R-7_group, MEF2A, MYH6; COL1A1/COL1A2 via purine metabolism for fat deposition); intercostal muscle proliferated at 6 months (closely correlated with g_Aeriscardovia, Actin, L-malic acid, l-serine) and GDI was potentially related to its 18-month fat deposition. Multi-omics showed Goat muscle development is coordinately regulated by specific genes, proteins, metabolites, and flora, providing breeding targets for better meat production. - Source: PubMed
Publication date: 2026/06/02
Sun YinggangDou XingtangYuan QingyuDuan RanZhan QiyingHui TaiyuQiao YanjunLi JiaqiLi WangshuGuo YunlongLyu DakunGe JiaqiXin JianingLiu FengzhiWang Zeying