Ask about this productRelated genes to: ARHGAP28 antibody
- Gene:
- ARHGAP28 NIH gene
- Name:
- Rho GTPase activating protein 28
- Previous symbol:
- -
- Synonyms:
- KIAA1314, FLJ10312
- Chromosome:
- 18p11.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-18
- Date modifiied:
- 2016-11-11
Related products to: ARHGAP28 antibody
Related articles to: ARHGAP28 antibody
- Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Although PEG-asparaginase (PEG-ASNase) is a key drug in treatment, hypersensitivity reactions, pancreatitis, and silent inactivation remain major challenges. Interindividual genetic variability influences drug metabolism and toxicity, and pharmacogenetic research aims to identify these variants early to predict specific responses effectively. - Source: PubMed
Publication date: 2025/11/13
Cecconello Daiane Kellerde Souza Silva Klerize Anecelyde Senna Evelin Cristine MendonçaCarlotto Lucas Alfeude Souza Amanda MásculoLins Mecneide MendesMagalhães Isis Maria Quezado Soaresde Sousa Ana Virgínia LopesEpelman SidneiCristofani LilianBarros Tais TerezianoPianovski MaraMoreira Larissa PolisRechenmacher CilianaDaudt Liane EstevesMichalowski Mariana Bohns - The present review summarizes recent studies indicating that the tail blastema of the lizard Podarcis muralis, initially represents a tumor-like outgrowth that later regulates its own proliferation and growth, producing a new tail. This regulation determines the formation of numerous integrated tissues in the regenerating tail that can be considered an example of natural cancer self-remission. This regulative ability likely derives from a balanced equilibrium between activated oncogenes and tumor suppressors, some of which are known from published studies on tail transcriptome and gene expression in P. muralis. The present review is centered on tumor suppressors and their tissue localization in the growing blastema-cone. A further indication for the presence of lizard tumor suppressors derives from recent experiments that tested proteins and RNAs extracted from lizard blastema-cones on human cancer cells vitality. These tests showed that these molecules inhibit proliferation of aggressive breast and prostate human cancer cells in-vitro. This inhibition suggests that lizard tumor suppressors can also influence human cancer cells, many of which degenerate after 3-4 days from the delivery of lizard proteins or RNAs-encapsulated into liposomes. These studies indicated that, aside main tumor suppressor proteins present in the blastema such as Arhgap28, APC, p53, RB, Fat2, also main ncRNAs such as Snord26, Snord50, and possibly also Snora24, might inhibit cancer cells proliferation. The identification of the main tumor suppressors in the regenerating blastema that inhibit human cancer cells in-vitro remains open. The evolution of this process of tumor self-remission indicated as tail regeneration in lizards remains unknown but is worth for further research. - Source: PubMed
Publication date: 2025/10/08
Alibardi Lorenzo - Diabetic kidney disease (DKD) represents serious diabetes-associated complications, and podocyte loss is an important histologic sign of DKD. The cellular and molecular profiles of podocytes in DKD have yet to be fully elucidated. - Source: PubMed
Publication date: 2025/04/02
Zhang FengxiaTang XianhuZeng ZhimeiCao ChunyuYun CaocuiShen YueNie ChaohongXiong YingChulian MaoWu YuehengXu Ruiquan - Acute lymphoblastic leukemia represents the most prevalent childhood cancer. Modern chemotherapy has significantly improved outcomes, achieving EFS rates of 80% and OS rates nearing 90% in developed nations, while in developing regions, rates remain below 50%, highlighting disparities, and this difference is due to several factors. Genetic variability plays a role in these drug response disparities, presenting single-nucleotide variations (SNVs). Pharmacogenetic research aims to pinpoint these SNVs early in treatment to predict specific drug responses effectively. This review aims to explore advancements in pharmacogenetics associated with asparaginase (ASNase). ASNase plays a crucial role in the treatment of ALL and is available in three formulations: , , and PEG ASNase. ASNase therapy presents challenges due to adverse effects, like hypersensitivity reactions. Identifying predictive markers for hypersensitivity development beforehand is crucial for optimizing treatments. Several pharmacogenetic studies have investigated the association between SNVs and the risk of hypersensitivity. Key genes include , , , , , and . Studies have highlighted associations between SNVs within these genes and hypersensitivity reactions. Notably, most pharmacogenetic investigations of hypersensitivity have focused on patients treated with , emphasizing the need for broader exploration across different formulations. Future research investigating these variants holds promise for advancing our understanding of ASNase's pharmacogenetics. - Source: PubMed
Publication date: 2024/08/28
Cecconello Daiane KellerSilva Klerize Anecely de Souzade Senna Evelin Cristine MendonçaRechenmacher CilianaDaudt Liane EstevesMichalowski Mariana Bohns - Gene expression patterns differ in different tissues, and the expression pattern of genes in the mammalian testis is known to be extremely variable in different species. To clarify how the testis transcriptomic pattern has evolved in particular species, we examined the evolution of the adult testis transcriptome in Theria using 10 species: two marsupials (opossum and Tasmanian devil), six eutherian (placental) mammals (human, chimpanzee, bonobo, gorilla, rhesus macaque, and mouse), and two outgroup species (platypus and chicken). We show that 22 testis-expressed genes are marsupial-specific, suggesting their acquisition in the stem lineage of marsupials after the divergence from eutherians. Despite the time length of the eutherian stem lineage being similar to that of the marsupial lineage, acquisition of testis-expressed genes was not found in the stem lineage of eutherians; rather, their expression patterns differed by species, suggesting rapid gene evolution in the eutherian ancestors. Fifteen testis-expressed genes are therian-specific, and for three of these genes, the evolutionary tempo is markedly faster in eutherians than in marsupials. Our phylogenetic analysis of () suggests the adaptive evolution of this gene in the eutherians, probably together with the expression pattern differentiation. - Source: PubMed
Publication date: 2024/08/09
Katsura YukakoShigenobu ShujiSatta Yoko