Ask about this productRelated genes to: NOLA3 antibody
- Gene:
- NOP10 NIH gene
- Name:
- NOP10 ribonucleoprotein
- Previous symbol:
- NOLA3
- Synonyms:
- NOP10P, MGC70651
- Chromosome:
- 15q14
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-06
- Date modifiied:
- 2019-04-23
Related products to: NOLA3 antibody
Related articles to: NOLA3 antibody
- - Source: PubMed
Publication date: 2026/01/23
Franco GiovanniBruno Lucia PiaAlviano Antonio MariaVankann LuciaBrümmendorf TimGuerra FabiolaVendemini FrancescaFaverio PaolaL'Imperio VincenzoCazzaniga GiovanniLuppi FabrizioBiondi AndreaBalduzzi AdrianaBeier FabianSaettini Francesco - Diffuse large B-cell lymphoma (DLBCL) is the most common non- Hodgkin lymphoma. Despite its high prevalence, treatment options remain limited, and molecular mechanisms underlying its pathogenesis remain poorly understood. This study aimed to identify potential biomarkers for DLBCL by integrating microarray analysis, Mendelian randomization (MR), and experimental validation. - Source: PubMed
Publication date: 2026/01/08
Zhang TingHe LiZhu Yidong - H/ACA small nucleolar ribonucleoproteins (H/ACA snoRNPs) facilitate essential cellular processes such as RNA modification, folding, and stability. Here, we present multiple cryo-EM structures of endogenous insect H/ACA snoRNPs containing two protomers assembled on a two-hairpin H/ACA snoRNA. By characterizing key protein-protein and protein-RNA interactions, we reveal the coordination of pseudouridylation activity across the two protomers which explains the predominance of two-hairpin structures in eukaryotic H/ACA snoRNAs. Moreover, we found that several mutations in H/ACA proteins associated with dyskeratosis congenita (DC) directly impair pseudouridine formation suggesting how these mutations disrupt RNA modification and ribosome biogenesis in this disease. Additionally, we uncover coordinated structural changes between Nop10, Nhp2, and the N-terminal extensions of Cbf5 in the 3' protomer that resemble active and inactive conformations and may regulate H/ACA snoRNP activity. In summary, this study provides detailed insight into the structure and function of RNA modification-competent H/ACA snoRNPs, which play pivotal roles in cellular processes including ribosome biogenesis, rRNA folding, (m)RNA modification, and telomere maintenance. - Source: PubMed
Publication date: 2025/12/18
Panwar Hemendra SinghVos Timothy JXie XiaoyanJang H JoshLee HyoungjooSheldon Ryan DWorden Evan JKothe Ute - Clear cell renal cell carcinoma (ccRCC) presents significant clinical challenges. This study investigates the causal relationship between telomere length (TL) and ccRCC risk using a comprehensive multicohort genetic approach. - Source: PubMed
Publication date: 2025/11/27
Zhang KaixiangHuang CongjunZhou JingFan KaiRuan MingXiao Youping - Glioma, the most prevalent primary brain tumor, exhibits dysregulated ribosome biogenesis closely linked to malignant behavior. However, the role of ribosome biogenesis in glioma and prognosis remains incompletely understood. This study aimed to construct a molecular signature based on ribosome biogenesis-related genes to predict patient survival and therapeutic response in glioma. - Source: PubMed
Publication date: 2025/10/08
Li YadanTang XiaolongZhao WenhuiSi XiuwenCui YanfangDong YanbinLiu Yongshuo