Ask about this productRelated genes to: NOLA3 antibody
- Gene:
- NOP10 NIH gene
- Name:
- NOP10 ribonucleoprotein
- Previous symbol:
- NOLA3
- Synonyms:
- NOP10P, MGC70651
- Chromosome:
- 15q14
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-06
- Date modifiied:
- 2019-04-23
Related products to: NOLA3 antibody
Related articles to: NOLA3 antibody
- Erythroblastic sarcoma is a rare and aggressive hematologic malignancy presenting as a mass-forming extramedullary proliferation of immature erythroid cells. Myeloid/lymphoid neoplasms with JAK2 rearrangement, most often PCM1::JAK2, may show eosinophilia, myelofibrosis, and expansion of immature erythroid precursors. NUTM1 rearrangements, initially recognized as defining alterations of NUT carcinoma, have subsequently been identified in selected hematologic malignancies but remain exceptionally rare in myeloid neoplasms. Here, we report an adult erythroblastic sarcoma harbouring concurrent PCM1::JAK2 and a novel NOP10::NUTM1 fusion, accompanied by partial chromosome 8p deletion and complicated by secondary hemophagocytic lymphohistiocytosis. To our knowledge, this is the first reported adult erythroblastic sarcoma with concurrent PCM1::JAK2 and NOP10::NUTM1 fusions. This case extends the molecular spectrum of erythroblastic sarcoma and underscores the value of integrated morphologic, immunophenotypic, cytogenetic, and genomic assessment in diagnostically challenging erythroid neoplasms. - Source: PubMed
Ge TongKuang DongMao XiaLiu SongyaWang JinAo QilinXiao Min - - Source: PubMed
Publication date: 2026/01/23
Franco GiovanniBruno Lucia PiaAlviano Antonio MariaVankann LuciaBrümmendorf TimGuerra FabiolaVendemini FrancescaFaverio PaolaL'Imperio VincenzoCazzaniga GiovanniLuppi FabrizioBiondi AndreaBalduzzi AdrianaBeier FabianSaettini Francesco - Diffuse large B-cell lymphoma (DLBCL) is the most common non- Hodgkin lymphoma. Despite its high prevalence, treatment options remain limited, and molecular mechanisms underlying its pathogenesis remain poorly understood. This study aimed to identify potential biomarkers for DLBCL by integrating microarray analysis, Mendelian randomization (MR), and experimental validation. - Source: PubMed
Publication date: 2026/01/08
Zhang TingHe LiZhu Yidong - H/ACA small nucleolar ribonucleoproteins (H/ACA snoRNPs) facilitate essential cellular processes such as RNA modification, folding, and stability. Here, we present multiple cryo-EM structures of endogenous insect H/ACA snoRNPs containing two protomers assembled on a two-hairpin H/ACA snoRNA. By characterizing key protein-protein and protein-RNA interactions, we reveal the coordination of pseudouridylation activity across the two protomers which explains the predominance of two-hairpin structures in eukaryotic H/ACA snoRNAs. Moreover, we found that several mutations in H/ACA proteins associated with dyskeratosis congenita (DC) directly impair pseudouridine formation suggesting how these mutations disrupt RNA modification and ribosome biogenesis in this disease. Additionally, we uncover coordinated structural changes between Nop10, Nhp2, and the N-terminal extensions of Cbf5 in the 3' protomer that resemble active and inactive conformations and may regulate H/ACA snoRNP activity. In summary, this study provides detailed insight into the structure and function of RNA modification-competent H/ACA snoRNPs, which play pivotal roles in cellular processes including ribosome biogenesis, rRNA folding, (m)RNA modification, and telomere maintenance. - Source: PubMed
Publication date: 2025/12/18
Panwar Hemendra SinghVos Timothy JXie XiaoyanJang H JoshLee HyoungjooSheldon Ryan DWorden Evan JKothe Ute - Clear cell renal cell carcinoma (ccRCC) presents significant clinical challenges. This study investigates the causal relationship between telomere length (TL) and ccRCC risk using a comprehensive multicohort genetic approach. - Source: PubMed
Publication date: 2025/11/27
Zhang KaixiangHuang CongjunZhou JingFan KaiRuan MingXiao Youping