Ask about this productRelated genes to: FAM83B antibody
- Gene:
- FAM83B NIH gene
- Name:
- family with sequence similarity 83 member B
- Previous symbol:
- C6orf143
- Synonyms:
- FLJ30642
- Chromosome:
- 6p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-06-09
- Date modifiied:
- 2018-11-15
Related products to: FAM83B antibody
Related articles to: FAM83B antibody
- The family with sequence similarity (FAM) gene family links pathological mechanisms of male infertility and oncogenesis. This review focuses on five key FAM members (FAM71D, FAM46C, FAM170A, FAM83D, and FAM172A), which were selected based on: clinical relevance (FAM83D as a breast cancer prognostic biomarker, hazard ratio, 1.29, p<0.05; FAM71D homozygous mutation c.440G>A associated with asthenoteratospermia); adequate experimental validation (in vitro assays, in vivo models, and clinical samples-for example, FAM170A knockout mice exhibit male infertility, with reduced transcription observed in patients); and recent impact (≥30 PubMed-indexed studies within 5 years and clearly defined mechanisms). In reproduction, FAM71D maintains sperm motility via calmodulin- plasma membrane Ca2+-ATPase (PMCA)- Ca2+ signaling, FAM46C anchors the sperm head-flagellum junction, and FAM170A regulates chromatin remodeling through ubiquitin- specific protease 7 (USP7)-mediated H2B deubiquitination. In oncology, FAM83D activates mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to drive hepatocellular carcinoma, whereas FAM172A dysregulates p38 mitogen-activated protein kinase in thyroid cancer. Translational advances include FAM83B nanodetection, the Fam20C inhibitor FL-1607 (IC50=2.1 μM), and clustered regularly interspaced short palindromic repeats (CRISPR)-corrected FAM170A. Cross-species functional divergence remains a challenge. FAM genes enable novel diagnostics and targeted therapies for reproductive and oncological care, with near-term clinical applications in personalized assisted reproductive technology and cancer precision medicine. - Source: PubMed
Publication date: 2026/03/11
Zhang PengLu SaiYin JiuLi Hemei - Reproductive traits are critical for improving productivity and profitability in the pig industry, and genome-wide association studies (GWASs) are a powerful tool in detecting genetic markers related to target traits. Genome imputation provides an effective approach to obtain a greater number of genetic markers from low-density sequencing data. China's pig industry recently introduced an imputation panel and is now seeking to determine what types of data are required to meet breeding needs. In this study, we collected and analyzed two pig sequencing datasets, including Yorkshire pig (YY), Landrace pig (LL), and Duroc pig (DD), genotyped by either an SNP chip ( = 816) or genotyping-by-targeted sequencing ( = 314), and applied an imputation strategy before validation in a third dataset ( = 2401). The aim of this study was to identify SNPs associated with reproductive traits and compare imputation results of two different types of data to evaluate whether sample size or marker density more strongly impacts imputation-enabled GWAS performance. Through a GWAS, we identified 73 significant SNPs from imputed Chip data across seven reproductive traits, 94 SNPs from imputed GBTS data across three traits, and 34 SNPs from the combined dataset across seven traits. Seven of these SNPs passed validation and were associated with number born alive, number born healthy, and gestation length. Gestation length (GL) and number born alive (NBA) are the most noteworthy traits. and are high-confidence candidate genes affecting GL and NBA, respectively. In addition to , , , , , , , , , , , , and are associated with GL. Moreover, in addition to , , , , and are associated with NBA. The results of this study indicate that sample size is of greater importance than marker density in imputation strategies and provide beneficial insights into genes affecting pigs' reproductive traits. - Source: PubMed
Publication date: 2026/02/12
Zhou JiekeFu YangZhang YingyingTu WeilongHuang JiLiang YaxuLi BusheZhang HejunLiu YanWang KejunWang HongyangTan Yongsong - SACK1G (aka FAM83G, PAWS1) plays a central role in activating canonical WNT signalling through interaction with the Ser/Thr kinase CK1α. The loss of CK1α binding and WNT signalling underlies the pathogenesis of palmoplantar keratoderma (PPK) caused by several reported mutations in the SACK1G gene. We modelled the scaffold anchor of CK1 (SACK1) domain of SACK1G and used fragment-bound structures of the SACK1B (FAM83B) dimer to guide our analysis. This allowed us to computationally predict several key residues near the fragment-binding site in SACK1G that may be important for its function. We mutated these residues, introduced them into SACK1G-/- DLD-1 colorectal cancer cells and investigated their ability to bind endogenous CK1α. We uncovered two SACK1G mutations, namely Y204A and I206A, that abolish interaction with CK1α similarly to the PPK pathogenic mutant A34E. Consistent with this loss of SACK1G-CK1α interaction, the molecular glue degrader of CK1α, DEG-77, fails to co-degrade the Y204A and I206A mutants while it still co-degrades native SACK1G. Our findings demonstrate the utility of our computational methods to uncover functional residues on proteins based on fragment-binding sites. - Source: PubMed
Utgés Javier SXuan Diane Lee ZhiLe Chatelier BruneGlennie LorraineMacartney ThomasWood Nicola TBarton Geoffrey JSapkota Gopal P - Prostate cancer (PCa), a common malignancy among men globally, requires the identification of biomarkers for early diagnosis and predicting progression. This study aimed to identify the key genes involved in the occurrence and development of PCa. - Source: PubMed
Publication date: 2025/06/26
Yuan JianxuZhou DalinYu Shengjie - FAM83B is a novel oncogene that mediates transformation. Despite emerging evidence supporting an association between FAM83B and cancer, a holistic view of FAM83B's correlation with pan-cancer is limited and its carcinogenic and radioresistant roles in esophageal squamous cell carcinoma (ESCC) remain to be explored. Using data from the TCGA project, GTEx database, and other online resources, we comprehensively examined FAM83B expression, genetic mutation, copy number variations (CNV), methylation, prognosis, function, immune-associated analyses, and drug sensitivity in pan-cancer. In addition, the biological function of FAM83B in ESCC was verified by CCK-8, colony formation assays, and flow cytometry. We discovered aberrant expression of FAM83B affected prognosis in various malignant tumors. Abnormal FAM83B mRNA expression was associated with CNV and methylation. Significant correlations were also observed between FAM83B expression and immune cell infiltration, immune checkpoints, tumor mutational burden (TMB), and microsatellite instability (MSI) in malignancies. In vitro experiments indicated that FAM83B mRNA and protein were upregulated in ESCC, and knockdown of FAM83B significantly inhibited the proliferation while promoting apoptosis and radiosensitivity of ESCC. These results suggest the multiple functional roles of FAM83B in pan-cancer and provide an attractive diagnostic and therapeutic biomarker for certain cancer types, especially ESCC. - Source: PubMed
Publication date: 2025/05/26
Guo WeiZhao XixiHuang XinranZhang RuijuanWang YuchenHe XinyuMa XiangyunHao YuGeng ShangyiPan ShupeiMa Hongbing