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- Cashmere goats are prized for their high-quality fibers, which are soft, fine, strong, and exhibit remarkable elasticity and luster. Cashmere growth occurs in secondary hair follicles and follows a distinct, periodic cycle. This study seeks to offer a more comprehensive understanding of the regulatory mechanisms driving cashmere growth, as well as the impact of exogenous melatonin, by integrating transcriptomic and proteomic data. - Source: PubMed
Publication date: 2025/11/14
Xie LuyaoLi ChunTian JindongFu ShaoyinSu RuiFeng CongChen Ming - In this study, the molecular mechanism of superfine fiber properties of Inner Mongolia Alpas cashmere was revealed by using fiber physical properties measurement and deep proteomics technology. The results showed that the average diameter of Alpas cashmere fiber (14.13 μm) was significantly lower than that of ordinary cashmere (17.29 μm). A total of 79 functional annotation proteins were identified by proteomics analysis, of which 28 were differentially expressed proteins (DEPs). The key findings showed that the down-regulated expression of keratins such as KRT5, KRT14, KRT8, KRT18, and keratin-associated proteins such as KRTAP11-1 and KRTAP15-1 were the core molecular nodes affecting fiber fineness. Functional enrichment analysis showed that these DEPs were significantly concentrated in biological processes such as intermediate fibrous tissue, keratinization, and epithelial cell differentiation, and were localized to keratin filaments. Further studies have found that the enrichment of the estrogen signaling pathway may indirectly affect fiber diameter by regulating the hair follicle cycle, and the interaction between serum albumin (ALB) and keratin group provides a key nutrient transport guarantee for fiber growth. PPI network analysis confirmed that KRT5, KRT14, and other proteins were at the hub of the regulatory network. Parallel reaction monitoring targeted verification ensures the reliability of proteome data. This study proposes that the down-regulation of specific keratins and their associated proteins leads to the formation of finer fibers by finely regulating the differentiation of hair follicle basal cells, cytoskeleton assembly, and keratinization. This study provides an important target for molecular breeding of cashmere goats. By targeting and improving these key genes, it is expected to cultivate new varieties with better cashmere and promote the sustainable development of the industry. - Source: PubMed
Publication date: 2025/10/14
Zhang ChongyanWang YichuanXing AnruXu BoWang MingkunWang ZhixinLiu Zhihong - Hair follicles (HFs) are complex organs that grow cyclically during mammals' growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration were screened, and we identified that the novel lncRNA, lncRNA2919, was significantly expressed during catagen. Here, we identified that lncRNA2919 has no coding potentiality and is highly expressed in the cell nucleus, and downregulates HF growth and development-related genes, inhibits cell proliferation, and promotes cell apoptosis in rabbit dermal papilla cells. lncRNA2919 recruits STAT1 to form a compound. As a key transcription factor, STAT1 regulates the transcriptional expression of KRTAP11-1. Our study revealed that lncRNA2919 is involved in HF cyclic regeneration through the -regulatory lncRNA2919-STAT1-KRTAP11-1 axis. This study elucidates the mechanism through which lncRNA2919 regulates HF growth and development and the role of lncRNA2919 as a new therapeutic target in animal wool production and human hair-related disease treatment. - Source: PubMed
Publication date: 2022/08/06
Zhao BohaoLi JialiLiu MingHu ShuaishuaiYang NaisuLiang ShuangZhang XiyuDai YingyingBao ZhiyuanChen YangWu Xinsheng - The development of hair follicle in cashmere goats shows significant periodic change, as with mice and humans. However, for cashmere goat with double-coat, the periodic change may be due to other regulatory molecules and signal pathways. To understand the mechanism of periodic development of hair follicle, we performed a weighted gene coexpression network analysis (WGCNA) to mine key genes and establish an interaction network by utilizing the NCBI public dataset. Ten coexpression modules, including 7689 protein-coding genes, were constructed by WGCNA, six of which are considered to be significantly related to the development of the hair follicle cycle. A functional enrichment analysis for each model showed that they are closely related to ECM- receptor interaction, focal adhesion, PI3K-Akt signaling pathway, estrogen signaling pathway, and so on. Combined with the analysis of differential expressed genes, 12 hub genes from coexpression modules were selected as candidate markers, i.e., , , , , , , , , , , and , which might be applied to improve cashmere production. - Source: PubMed
Publication date: 2021/01/27
Wang JianfangSui JieMao ChaoLi XiaoruiChen XingyiLiang ChengchengWang XiaohuiWang Si-HuJia Cunling - Keratin-associated protein (KAP), the structural protein molecule of hair fibers, plays a key role in determining the physical properties of hair. Studies of Krtap11-1 have focused only on its localization. Functional studies of Krtap11-1 in hair follicle development have so far not been reported. - Source: PubMed
Publication date: 2020/09/21
Liang ShuangBao ZhiyuanZhao BohaoZhou TongLi JialiLiu MingHu ShuaishuaiYang NaisuChen YangWu Xinsheng