Ask about this productRelated genes to: IARS antibody
- Gene:
- IARS NIH gene
- Name:
- isoleucyl-tRNA synthetase
- Previous symbol:
- -
- Synonyms:
- ILRS, IARS1
- Chromosome:
- 9q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-07-11
- Date modifiied:
- 2016-10-05
Related products to: IARS antibody
Related articles to: IARS antibody
- Childhood trauma often leads to maladaptive emotional schemas that affect social adjustment and self-compassion. This study aimed to investigate the correlation of childhood trauma with social adjustment and self-compassion, based on the moderating role of emotional schemas in adolescents with risky behaviors. - Source: PubMed
Publication date: 2026/07/01
Dabiri SolmazEbrahimi Moghaddam HosseinBabakhani Narges - Male patients with the classical phenotype of Fabry disease (FD) are at risk of developing inhibiting antidrug antibodies (iADAs) against recombinant α-galactosidase-A, administered in the form of enzyme replacement therapy (ERT). The presence of ADAs is linked to infusion-associated reactions (IARs) and reduced ERT effectiveness. This study evaluates the incidence of iADAs and IARs in ERT treated classical male FD patients, their interrelatedness and the effect of an adjusted ERT initiation protocol, aimed at inducing immune tolerance. In this monocenter cohort study, a retrospective analysis was performed to evaluate the occurrence of iADAs and IARs. Prospectively, a stepwise dose escalation ERT initiation protocol was evaluated in classical male FD patients with a calculated high risk of iADA formation and compared to the standard initiation protocol. Retrospectively (n = 52), the proportion of patients experiencing IARs was higher in patients that developed iADAs (20/27 seropositive patients, 0/19 seronegative, p < 0.001). Higher iADA titers were associated with persisting iADA titers (p = 0.004). Prospectively (n = 17), none of the patients in the intervention group (stepwise dose escalation) experienced IARs (0/8), compared to half of the patients in the control group (5/9, p = 0.029). The proportion of patients developing iADAs was not different between the two groups (respectively, 4/8 and 6/9, p = 0.52). To conclude, iADA development is associated with the occurrence of IARs. The stepwise dose escalation at ERT initiation used in the current study in a single cohort seems to prevent IARs in male patients with classical FD, but does not seem to prevent iADA development. - Source: PubMed
Janssens Maudvan der Veen Sanne Jvan Dussen Lauravan Kuilenburg André B PBrands Marion M M GLangeveld Mirjam - Critical care competencies are increasingly relevant across specialties, yet structured exposure in undergraduate medical education (UME) remains variable. We describe the design, implementation, and early outcomes of a four-week, modular ICU clerkship. - Source: PubMed
Publication date: 2026/07/16
Arkin NicoleRamaswamy TaraCarvalho BernadetteKache SaraswatiNassar Aussama KhalafJohnson Christine L CHennessey ErinBarr Juliana - Enzyme replacement therapy (ERT) is the standard treatment for patients with Pompe disease, a hereditary metabolic myopathy. While ERT in the home situation is increasingly common in adults with Pompe disease, experience in children remains limited due to higher dosing requirements and increased risk of infusion-associated reactions (IARs). We analysed the results of the in-hospital and home-based infusion programme applied in the Netherlands to children since 1999 to provide guidance. - Source: PubMed
Publication date: 2026/07/20
Ditters Imke A MHuidekoper Hidde HHardon Jacqueline FKruijshaar Michelle Evan der Ploeg Ans Tvan den Hout Johanna M P - Modern connected and automated vehicles are equipped with various onboard sensors, which continuously generate high-rate perception data. The reliable and timely sharing of such sensor data among neighboring vehicles requires high-capacity and low-latency vehicle-to-vehicle (V2V) communications. Millimeter-wave (mmWave) technology is a promising solution for supporting such high-rate transmission. However, mmWave V2V communication may be severely affected by non-line-of-sight (NLOS) blockage caused by limited transmission range, roadside obstacles, and moving vehicles. Relay forwarding can improve communication reliability and extend transmission distance, while intelligent reflecting surfaces (IRSs) can construct virtual line-of-sight (LOS) links to mitigate NLOS blockage. In this paper, we propose deploying IRSs on urban roadsides to improve mmWave multi-hop V2V communication for vehicular sensor-data sharing by integrating IRS-assisted link selection into multi-hop relay forwarding. However, IRS deployment introduces new challenges in relay selection and directional transmission coordination under interference. To address these challenges, we propose an IRS allocation and relay selection (IARS) scheme for IRS-assisted multi-hop V2V communication. The proposed scheme is based on a transmission evaluation function that jointly considers inter-vehicle distance, link quality, and concurrent transmissions. Simulation results show that the proposed IARS scheme can effectively improve communication reliability and reduce multi-hop delay, thereby supporting reliable and timely sensor-data sharing in urban vehicular networks. - Source: PubMed
Publication date: 2026/06/16
Yin XiaojunDu XuyangWu XiaohanZhang Xinming