Ask about this productRelated genes to: GNB2 antibody
- Gene:
- GNB2 NIH gene
- Name:
- G protein subunit beta 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-20
- Date modifiied:
- 2016-03-03
- Gene:
- RACK1 NIH gene
- Name:
- receptor for activated C kinase 1
- Previous symbol:
- GNB2L1
- Synonyms:
- Gnb2-rs1, H12.3
- Chromosome:
- 5q35.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-19
- Date modifiied:
- 2019-02-01
Related products to: GNB2 antibody
Related articles to: GNB2 antibody
- The influenza A virus (IAV) protein PB1-F2, which is encoded by an alternative ORF of the PB1 polymerase gene, has been implicated as an important virulence factor and apoptosis inducer. However, the molecular mechanism of PB1-F2 function remains elusive. In this study, eight cellular proteins were identified as potential PB1-F2 interacting partners using the yeast two-hybrid system. Two positive candidate proteins, guanine nucleotide binding protein (G protein) beta polypeptide 2 (Gβ2) and macrophage migration inhibitory factor (MIF), were selected to be further characterized. The interaction of MIF and Gβ2 with PB1-F2 was confirmed by both GST pull-down and co-immunoprecipitation assays. Confocal laser microscopy showed that the interaction between PB1-F2 and the two cellular proteins occurred in the cytoplasm. The novel interactions between PB1-F2 and host proteins provide further pieces of evidence in the investigation of the pathogenic mechanism of IAV. - Source: PubMed
Guan Z HZhang M LHou P LDuan MCui Y MWang X R