Ask about this productRelated genes to: CHN2 antibody
- Gene:
- CHN2 NIH gene
- Name:
- chimerin 2
- Previous symbol:
- -
- Synonyms:
- ARHGAP3, RhoGAP3
- Chromosome:
- 7p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-08-28
- Date modifiied:
- 2016-10-05
Related products to: CHN2 antibody
Related articles to: CHN2 antibody
- Cervical cancer remains a leading cause of cancer related mortality in women worldwide. Cisplatin (CP) is a cornerstone chemotherapeutic agent; however, its clinical utility is constrained by dose-limiting toxicity and the emergence of drug resistance, necessitating novel combinatorial strategies. This study investigated the therapeutic potential of combining CP with Aloe vera extract (AVE) against HeLa cervical cancer cells and the normal human skin fibroblast cell line CCD-1072Sk. Cytotoxicity assays performed using the xCELLigence Real-Time Cell Analysis (RTCA) system determined IC values of 18.45 µM for CP and 18.88 µg/mL for AVE in HeLa cells, compared with 53.31 µM and 19.09 µg/mL, respectively, in CCD-1072Sk cells. The CP + AVE combination exhibited markedly enhanced antiproliferative activity in HeLa cells compared with CP alone, while CCD-1072Sk cells exhibited continued but decelerated proliferation, suggesting a differential cellular response. Seahorse metabolic analysis revealed that AVE, both alone and in combination with CP, markedly increased mitochondrial oxygen consumption rate (OCR) and ATP-linked respiration in HeLa cells, indicating induction of sustained bioenergetic stress beyond the cells' adaptive capacity. Transcriptomic profiling of HeLa cells identified 453 differentially expressed genes (DEGs) upon combination treatment, with significant downregulation of oxidative phosphorylation (OXPHOS) components, mitochondrial electron transport chain subunits, and the fatty acid metabolism gene CPT1B, collectively indicating a severe disruption of cellular energy metabolism. DepMap database analysis confirmed that downregulated targets including CPT1B and CHN2 are functionally important for HeLa cell survival. Collectively, these data suggest that AVE drives HeLa cells into a hypermetabolic state that overloads mitochondrial capacity; in combination with CP, this converging bioenergetic stress produces enhanced cytotoxicity descriptively consistent with an additive interaction (a term used here in its dose-response sense, as no formal combination-index or Bliss/Loewe synergy analysis was performed) at the IC doses employed. This study highlights the potential of AVE as a metabolically active combinatorial agent capable of potentiating CP efficacy by targeting cancer cell energy metabolism, and provides a mechanistic basis for further investigation. - Source: PubMed
Publication date: 2026/08/06
Kul Köprülü TuğbaErkal Çam Burçin - The diagnosis, prevention, and treatment of tuberculosis (TB) are crucial for controlling its spread. This study aimed to identify potential pathogenic mechanisms and biomarkers for differentiating active pulmonary TB (PTB) and latent TB (LTB). - Source: PubMed
Publication date: 2026/05/15
Wu JingWen YaHuang Suhui - Gray leaf spot (GLS) is a devastating foliar disease that causes substantial yield losses in maize. The identification and utilization of GLS resistance genes in hybrid cultivation is a critical strategy for GLS-resistance breeding. The mapped quantitative trait loci (QTLs), the genome-wide associated quantitative trait nucleotides (QTNs), and multi-omics datasets provide foundational resources for gene discovery. Here, we integrated GLS resistance QTLs and QTNs to identify 164 QTL hotspots, 13 meta-QTL (MQTL) regions, and 86 QTN hotspots. We further extracted a total of 1,343 recurrent differentially expressed genes (DEGs) from multiple transcriptomic studies, including 200 high-confidence DEGs. These DEGs exhibited significant enrichment in key biological pathways, including ‘metabolic pathways’ and ‘plant-pathogen interaction’, implicating them in defense resistance. Through integrative analysis, we identified 340 high-confidence candidate genes in multiple dimensions, with five locating in both QTL hotspots and MQTL regions. Key candidate genes function within known resistant network, such as chitinase (chn2, chn7, chn17), wall-associated kinase-like (WAKLs) (wakl23, wakl56, and wakl27), and calcium-dependent protein kinase (CPKs) (cpk20, cpk36, and cpk25). Expression profiling revealed that most candidate genes were consistently down- or up-regulated at the reproductive stage. These findings provide novel genetic resources and mechanistic insights for GLS-resistance breeding in maize. - Source: PubMed
Publication date: 2026/03/17
Zhu YonghuiZhang XiaoWen XuantaoYang LinHe YuanyuanHe Wenzhu - Despite the substantial global impact of ischemic stroke, current therapeutic options remain limited and only partially effective. To advance neuroprotective strategies that could improve the safety and efficacy of existing treatments while preserving brain tissue, we synthesized and evaluated seven new nitrones (, , ) and oximes (, , , ) derived from different neuroactive steroids-ethisterone (), mifepristone () and stanolone ()-in an in vitro model of cerebral ischemia. Overall, these derivatives exhibited neuroprotective and antioxidant effects superior to those of the reference compounds cholesteronitrone , α-tert-butyl nitrone () and N-acetylcysteine (). Notably, nitrones showed greater neuroprotective, anti-necrotic, and antioxidant potency than their corresponding oximes, regardless of the degree of molecular conjugation. Among them, the stanolone-derived nitrone , which lacks conjugated double bonds, displayed the most balanced and robust profile, consistently enhancing cell viability, reducing necrotic cell death, and suppressing superoxide anion production. Consequently, has been selected as a promising lead compound for further in vivo studies of cerebral ischemia. - Source: PubMed
Publication date: 2025/11/27
Izquierdo-Bermejo SaraChioua MouradHadjipavlou-Litina DimitraLópez-Muñoz FranciscoMarco-Contelles JoséOset-Gasque María Jesús - Ph-like ALL has gene expression profile similar to Ph-positive ALL but without the BCR::ABL1 fusion. The disease presents higher rates of severe clinical features and is associated with unfavorable outcomes. There is still no standard pipeline for molecular characterization of the disease, and no valid predictor gene panel is available worldwide. - Source: PubMed
Publication date: 2024/10/02
Thangrua NonthayaSiriboonpiputtana TeerapongRerkamnuaychoke BudsabaChareonsirisuthigul TakolKorkiatsakul VeerawatPongphitcha PongpakMukda EkcholChutipongtanate SomchaiPakakasama Samart