Ask about this productRelated genes to: ZW10 antibody
- Gene:
- ZW10 NIH gene
- Name:
- zw10 kinetochore protein
- Previous symbol:
- -
- Synonyms:
- KNTC1AP
- Chromosome:
- 11q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-11
- Date modifiied:
- 2016-10-05
Related products to: ZW10 antibody
Related articles to: ZW10 antibody
- The spindle assembly checkpoint (SAC) prevents sister chromatids separation until all chromosomes are properly attached to spindle microtubules and bi-oriented. SAC controls the metaphase-to-anaphase transition by inhibiting the anaphase promoting complex/cyclosome (APC/C). A critical step in this process is the recruitment of the Mad1-Mad2 complex to unattached kinetochores mediated by the KBB pathway (KNL1-Bub3-Bub1) and the RZZ pathway (Rod-Zw10-Zwilch). Here, we show that hSpindly contributes to the regulation of Mad1-Mad2 recruitment through the RZZ pathway. We demonstrate that hSpindly is a dynamic protein that oligomerizes at unattached kinetochores, and we identify threonine 552 as a key residue controlling its mobility and function. A non-phosphorylatable mutant (T552A) displays reduced dynamics at kinetochores, impairs SAC signaling, and increases cellular resistance to antimitotic drugs. Altogether, our findings identify hSpindly as a dynamic regulator of SAC signaling and potential therapeutic target for overcoming resistance to mitotic inhibitors. - Source: PubMed
Publication date: 2026/06/16
Mora-Santos MarHerrero-Ruiz JoaquínFennema-Galparsoro DirkBelmonte-Fernández AlejandroFerrandiz NuriaRomero Francisco - Oocyte aneuploidy is a major contributor to age-related fertility decline, but the effective treatments are still unavailable. The spindle assembly checkpoint (SAC), which functions to maintain chromosomal euploidy in oocytes, may become impaired with aging, manifesting primarily as an aberrant acceleration of meiotic progression. In the present study, we investigated the effects, effective components, and molecular mechanisms of the secretome of mesenchymal stem cells (MSC-sec) in reducing aneuploidy by alleviating the accelerated meiotic progression of aged mouse oocytes. - Source: PubMed
Publication date: 2026/06/13
Mi XinZhou JialiChen CaiyiZhou JingYang YajuanWang HongyanJiao XueQin YingyingChen Zi-JiangZhao Shidou - This study investigated the interactive effects of warming and inundation on methane (CH) fluxes and soil physicochemical mechanisms in the littoral wetland of Qinghai Lake. Soil samples were collected from the Bird Island littoral wetland. Eight treatments were established: natural control (CK), different inundation depths (S0, S10, S20), warming alone (ZWCK), and warming combined with inundation (ZW0, ZW10, ZW20). CH fluxes were measured over one year using an ABB LGR analyzer. Principal component analysis (PCA) and Mantel tests were used to identify environmental drivers. The main findings are as follows: (1) Under different water level treatments, CH fluxes showed a unimodal seasonal pattern, peaking in autumn. Warming and the interactive treatments shifted the emission pattern to bimodal or multimodal and significantly increased emission intensity. The warming-alone group had the highest annual emission, with anomalously high winter emission (47.683 μg·m·h). Under the ZW20 treatment, emissions were synergistically enhanced in summer and autumn but turned to suppression in winter. (2) PCA showed that the carbon nitrogen pool (70.5%) and the salinity pH gradient (14.9%) were the main drivers of soil variation. The interactive effects on carbon-nitrogen dynamics shifted with season: warming promoted accumulation in spring; warming with shallow inundation retained carbon-nitrogen in summer, but deep inundation caused loss; warming with deep inundation formed a nutrient center in autumn; inundation dominated accumulation in winter, while warming increased loss. (3) Mantel tests showed that carbon-nitrogen components were highly correlated across seasons, but were strongly and positively correlated with CH flux only in autumn (Mantel's r ≥ 0.4, < 0.05), indicating autumn as the key window. These findings provide important insights into carbon cycling processes and regulatory mechanisms of alpine wetlands under future climate change scenarios. - Source: PubMed
Publication date: 2026/05/27
Zhao HairuiYang ZiweiYang YanfenCao MingzhuMa YuyuChen ChenZhu ShuchangChen Kelong - Immune dysfunction in the tumor microenvironment contributes to the progression of non-small cell lung cancer (NSCLC) in patients with chronic obstructive pulmonary disease (COPD). This study aimed to elucidate the roles of the RNA-binding protein Aly/REF export factor (ALYREF) and its target, ZW10 interacting protein (ZWINT), in mediating CD4 T cell dysfunction in this context. - Source: PubMed
Publication date: 2026/03/23
Li ShiMinSong QiDong FuShiLiu HaiYangMeng ShanShanHu Xin - Zeste White 10 (ZW10) is a key component of the spindle assembly checkpoint (SAC) that maintains chromosomal stability during mitosis. Dysregulation of ZW10 can cause chromosomal instability and aneuploidy-hallmarks of many cancers, including breast cancer, particularly triple-negative breast cancer (TNBC). However, its prognostic and therapeutic relevance in breast cancer remains unclear. - Source: PubMed
Publication date: 2026/03/11
Bellah Sm FaysalHossen Md AlimBillah Sm SakerDurojaye Olanrewaju AyodejiRaihan Md Obayed