Ask about this productRelated genes to: RBBP7 antibody
- Gene:
- RBBP7 NIH gene
- Name:
- RB binding protein 7, chromatin remodeling factor
- Previous symbol:
- -
- Synonyms:
- RbAp46
- Chromosome:
- Xp22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-23
- Date modifiied:
- 2016-10-05
Related products to: RBBP7 antibody
Related articles to: RBBP7 antibody
- Asymmetric transcription of noncoding RNA LincGET is currently recognized as the earliest event regulating the first cell fate decision in mammalian embryogenesis. However, whether key protein factors modulate this process remains elusive. Here, we identify RBBP7 as the earliest protein factor regulating developmental cell fate in mammals. Loss of RBBP7 drives cells towards ICM lineage. In mouse late 2-cell embryos, unequal translation of Rbbp7 contributes to its asymmetric protein distribution, which subsequently induces inversed asymmetric histone acetylation H3K9ac by interaction with HDAC1, thereby promoting cell differentiation. Interestingly, RBBP7 and LincGET exhibit a consistent asymmetric tendency but direct different cell fates; depletion or overexpression of both Rbbp7 and LincGET restored the cell fate bias, suggesting a coordinated regulatory mechanism during initial lineage specification. In summary, our study reveals RBBP7 as a new protein factor and elucidates its role in the first cell fate decision. - Source: PubMed
Publication date: 2026/08/18
Ju Lin-FangHan XiaoZhang DanruXu Heng-JiJia ShaokangLiu Meng-XiaLiu YanchenCai Yu-TingChen Yu-ShengGao Chun-ChunZhao Yong-LiangHao YajingWang Xiu-JieLi DangshengZhou XiangYang YingHan JianyongYang Yun-Gui - Ovarian cancer (OC) remains one of the leading causes of gynecological cancer-related mortality, with limited biomarkers for early detection and prognosis. Changes in DNA methylation-stable and detectable in blood-are potential candidates for clinical application. In our earlier genome-wide methylation study involving monozygotic twins where one had ovarian cancer and the other did not, we identified two genes, RBBP7 and RIBC1, as differentially methylated. These findings laid the groundwork for further targeted investigation. - Source: PubMed
Publication date: 2026/07/29
Erdoğan Özge ŞükrüoğluErciyas Seda KılıçDemirbaş Betül ÇelikDinç AhmetÜnal ElifUğurlucan Funda GüngörÖdemiş Demet AkdenizPasin ÖzgeSaip Pınar MuallaYazıcı HülyaTuncer Seref Bugra - Polycomb repressive complex 2 (PRC2) silences MHC class I antigen presentation across cancer types, yet the role of its core scaffolding subunit SUZ12 in pancreatic ductal adenocarcinoma (PDAC) immune phenotypes remains poorly characterized. - Source: PubMed
Publication date: 2026/06/23
Wang ZhuoxinJin ChenyangYin FeiWu XuejiaoYang Zilin - Esophageal carcinoma has high mortality and poor prognosis. Current multimodal therapies remain limited by scarce actionable targets and suboptimal systemic efficacy. Tumor stemness programs sustain invasive, therapy-resistant cells and may offer new opportunities for precision stratification and treatment. - Source: PubMed
Publication date: 2026/05/19
Liu YubingYang XiaoDu RuiqinWu LanxiangWu Qingchen - The genetic contributions of the X chromosome to Alzheimer's disease (AD) remain poorly understood yet are expected to importantly shape sex differences in AD. We therefore performed large-scale X-chromosome-wide association studies (N=1,240,451), evaluating differential risk due to sex, *4, and escape from X-chromosome inactivation, finding most X-linked loci appear relevant to female-biased AD etiology. In evaluating genetic pleiotropy with hormonal, lipid, and brain imaging traits, we discovered X-linked AD loci converged on white matter traits, particularly in the anterior corona radiata and splenium of the corpus callosum. Through brain-centric functional genomics analyses, we then nominated candidate causal genes, including 5 that appeared highly robust. Notably, we found the escape gene decreases AD risk in *4 carriers likely through higher expression in excitatory neurons to counter tau-related neurodegeneration. Altogether, we provide an atlas of sex and *4-informed candidate X-linked AD risk loci, genes, and mechanisms that will guide future studies. - Source: PubMed
Publication date: 2026/05/06
Cook NoahZeng YoujieYang ChenyuJiang ZhiwenWang Ting-ChenLe Guen YannCody KarlyJohnson MatthewZhang RuiMerritt Victoria CHauger Richard L Koran Mary EllenMormino Elizabeth CGordon BrianDeCasien AlexAndrews SheaDumitrescu LoganArcher DerekHohman Timothy JPottier CyrilCruchaga CarlosSherva RichardLogue MarkNapolioni ValerioGreicius Michael DBelloy Michael E