Ask about this productRelated genes to: ASGR1 antibody
- Gene:
- ASGR1 NIH gene
- Name:
- asialoglycoprotein receptor 1
- Previous symbol:
- -
- Synonyms:
- CLEC4H1
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-24
- Date modifiied:
- 2016-10-05
Related products to: ASGR1 antibody
Related articles to: ASGR1 antibody
- Asialoglycoprotein receptor 1 (ASGR1), a hepatocyte-specific receptor, represents a potential therapeutic target for hypercholesterolemia. However, liver safety risks of ASGR1-targeted therapies remain poorly characterized. This study aims to investigate the impact of ASGR1 deficency on liver fibrosis and its underlying mechanisms. - Source: PubMed
Zhu HuiHuang Xin-PingYou KaiChen YanLi Peng-HuiTao Jia-WangYu Xiao-RuiXu Jie-HuiXu Guo-ShengLi Yin-Xiong - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease with limited therapeutic options. Hepatocyte senescence is a critical driver of MASLD progression, but its upstream regulators remain poorly understood. This study aims to investigate the role and mechanism of high expression of asialoglycoprotein receptor 1 (ASGR1) in MASLD-associated hepatocyte senescence. - Source: PubMed
Publication date: 2026/08/19
Zhang Chen-YuDing JieSun Yi-JiaZhong Wen-JingYang Nan-Si-YuLi Pei-ZeZheng Jia-HuiYang Jin-TongLiang Li-YingZhou YongTang Si-YuanHuang Xiao-Ting - Barker's hypothesis posits that adverse in utero exposures, often reflected by low birthweight, increase adult cardiovascular disease (CVD) risk. However, underlying mechanisms remain unclear; identifying potentially causal mediators is crucial for developing effective interventions. Emerging research suggests epigenetic modifications may influence CVD traits from early life. We aimed to identify DNA methylation (DNAm) signatures that mediate birthweight and CVD traits and to establish their biological relevance across three developmental time points using multi-omics integration. - Source: PubMed
Publication date: 2026/08/14
Tang John YenNg Nicole Ying TingKwok Alice Wing SzeMak Christopher Chun YuCheung Yiu-FaiChung Brian Hon Yin - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent but heterogeneous condition. How its genetic diversity shapes systemic disease risk remains unclear. We aimed to identify genetically defined MASLD subtypes, assess their effects on extrahepatic diseases, and uncover potential protein-mediated mechanisms. - Source: PubMed
Publication date: 2026/08/11
Weng YuxuanDu MingyiWu TianhaoLu LinyaoJiang YanfengSuo ChenJin LiZhang TiejunChen XingdongLiu Zhenqiu - - Source: PubMed
Publication date: 2026/07/20
Dong Le-WeiSong Bao-Liang