Ask about this productRelated genes to: ATG16L1 antibody
- Gene:
- ATG16L1 NIH gene
- Name:
- autophagy related 16 like 1
- Previous symbol:
- APG16L, ATG16L
- Synonyms:
- WDR30, FLJ10035, ATG16A
- Chromosome:
- 2q37.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-22
- Date modifiied:
- 2015-11-24
Related products to: ATG16L1 antibody
Related articles to: ATG16L1 antibody
- Glioblastoma (GBM), a rare, highly aggressive and chemoresistant brain cancer, exhibits profound metabolic plasticity that relies, in part, on aberrant transforming growth factor-β (TGF-β) signaling. Such plasticity was recently associated with TGF-β-regulated apoptosis and autophagy. Here, we questioned whether TGF-β-regulated apoptotic/autophagic phenotypes are recapitulated in a preclinical in vitro 3D spheroid culture model of human U87 GBM-derived cells, and how metabolic alterations affect such phenotypes. - Source: PubMed
Publication date: 2026/03/30
Payet-Desruisseaux MaellisZgheib AlainDanalache Bogdan AlexandruDesjarlais MichelAnnabi Borhane - Autophagy-mitophagy pathways are essential for regulating immune homeostasis. However, their contribution to population-level chronic low-grade systemic inflammation (SI) remains unclear. The objective was to investigate the association between variation in the genes related to the autophagy-mitophagy pathways and SI, and to examine whether lifestyle factors modify this relationship. We conducted genome-wide association studies and gene-set enrichment analyses using data from the Korean Genome and Epidemiology Study (KoGES, n = 28,102) and UK Biobank (UKBB, n = 343,892). SI was defined as an elevated white blood cell count or high-sensitivity C-reactive protein. Using Core Longevity State Vectors (CLSVs)-gene sets representing immune-longevity pathways derived from comparative transcriptomic analysis-we tested six pathways and constructed a weighted genetic risk score (GRS) from significant variants. Gene-lifestyle interactions were examined with respect to major dietary and lifestyle factors. Among six CLSVs, only CLSV-2 (mitophagy and autophagy) showed a significant association with SI (β = 0.425, = 0.008). Six single nucleotide polymorphisms (SNPs) in autophagy-mitophagy genes (, , , , , and ) were associated with SI in KoGES ( < 5 × 10), and ten SNPs (genes selected in KoGES plus , , , ) reached genome-wide significance in UKBB ( < 5 × 10). A higher GRS was associated with increased SI in both cohorts and was strongly associated with metabolic syndrome (MetS, OR = 1.91 in KoGES; OR = 1.62 in UKBB). SI was characterized by neutrophilia with relative lymphopenia. In UKBB, significant gene-lifestyle interactions were observed for diet, physical activity, smoking, and alcohol ( < 0.01). Favorable lifestyle factors reduced SI most effectively in individuals with protective genotypes. Among individuals with a high vegetable/fruit intake, SI prevalence was 35%, 36%, and 38% in the negative-, zero-, and positive-GRS groups, respectively, compared with 36%, 45%, and 48% in the low-intake groups. In conclusion, genetic variations in autophagy-mitophagy pathways specifically influence SI. Genetic predisposition substantially modifies the benefits of lifestyle, underscoring the importance of integrating genetic and lifestyle factors in understanding SI susceptibility. - Source: PubMed
Publication date: 2026/03/27
Choi YoungjinPark Sunmin - UFMylation plays an essential role in multiple physiological processes. Ribosomal protein L26 (RPL26), a principal target of UFMylation and a component of the ribosomal 60S subunit, is directly involved in protein synthesis. However, the biological significance of RPL26 UFMylation in intestinal epithelial cells (IECs) and intestinal homeostasis remains largely unknown. - Source: PubMed
Publication date: 2026/04/08
Xu JunjieChen ZhixiLi PingYan JingjingDeng ZihanChen FanghuiCai Yafei - Modified Ma-Xing-Shi-Gan Decoction (MMXSGD) has been widely used in the treatment of Klebsiella pneumoniae (KP)-induced pneumonia, which is derived from the classical traditional Chinese medicine formula Ma-Xing-Shi-Gan Decoction. - Source: PubMed
Publication date: 2026/04/04
Jiang QiruiGeng RuizhiSun XiaoluoTao SianLiu HaihuiZhang JingLiang YuWu WenjunLiu WenpingXi ChongchengWang DongMao YiLi BaixueFeng QuanshengLiu Jibin - The transcription factor erythroid 2 (NFE2)-related factor 2 (NRF2) is a key regulator of cellular homeostasis. Recent discoveries have identified agonists of NRF2 as inducers of broad cellular resistance to viral infection including SARS-CoV-2. Nevertheless, it is still unclear to what extent NRF2 itself is an inducer of anti-viral immunity and its downstream antiviral effectors have not been mapped. Here, we first demonstrate through specific genetic activation and silencing that NRF2 restricts SARS-CoV-2 replication. We then used a focused CRISPR-activation screen to map antiviral NRF2-inducible effector genes that restrict replication of SARS-CoV-2, Influenza A virus (IAV), Herpes Simplex virus 1 (HSV1) and Vaccinia virus (VACV). This approach allowed us to identify a range of antiviral effectors each of which restrict members of one or more virus families. Importantly, we identified the NRF2-inducible selective autophagy receptor p62/SQSTM1 as a broadly effective restriction factor across all the tested viruses. Importantly, p62 inhibited SARS-CoV-2 replication in cells treated with the lysosomal inhibitor bafilomycin A1, as well as in cells deficient in the autophagy protein ATG5. Similarly, p62 inhibited replication of HSV1 and IAV independently of ATG5 and ATG16L1 respectively. Thus, NRF2 restricts viral replication through a hitherto underappreciated network of antiviral restriction factors effective across multiple virus families. Importantly, we identify p62 as a broadly acting antiviral effector that restricts viral replication independently of canonical autophagy. - Source: PubMed
Publication date: 2026/04/01
Pedersen AliceBlay-Cadanet JuliaStorgaard JacobHernaez BrunoThyrsted JacobBach-Nielsen Cecilie STwayana KrishnaJørgensen Sofie ERio-Bergé ClàudiaPoulsen CecilieThielke Anne LThomsen Emil AKalucka JoannaOlagnier DavidLuo YonglunReggiori FulvioMogensen Trine HAlcamí AntonioHansen Anne LouiseHolm Christian K