Ask about this productRelated genes to: CHN2 antibody
- Gene:
- CHN2 NIH gene
- Name:
- chimerin 2
- Previous symbol:
- -
- Synonyms:
- ARHGAP3, RhoGAP3
- Chromosome:
- 7p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-08-28
- Date modifiied:
- 2016-10-05
Related products to: CHN2 antibody
Related articles to: CHN2 antibody
- Despite the substantial global impact of ischemic stroke, current therapeutic options remain limited and only partially effective. To advance neuroprotective strategies that could improve the safety and efficacy of existing treatments while preserving brain tissue, we synthesized and evaluated seven new nitrones (, , ) and oximes (, , , ) derived from different neuroactive steroids-ethisterone (), mifepristone () and stanolone ()-in an in vitro model of cerebral ischemia. Overall, these derivatives exhibited neuroprotective and antioxidant effects superior to those of the reference compounds cholesteronitrone , α-tert-butyl nitrone () and N-acetylcysteine (). Notably, nitrones showed greater neuroprotective, anti-necrotic, and antioxidant potency than their corresponding oximes, regardless of the degree of molecular conjugation. Among them, the stanolone-derived nitrone , which lacks conjugated double bonds, displayed the most balanced and robust profile, consistently enhancing cell viability, reducing necrotic cell death, and suppressing superoxide anion production. Consequently, has been selected as a promising lead compound for further in vivo studies of cerebral ischemia. - Source: PubMed
Publication date: 2025/11/27
Izquierdo-Bermejo SaraChioua MouradHadjipavlou-Litina DimitraLópez-Muñoz FranciscoMarco-Contelles JoséOset-Gasque María Jesús - Ph-like ALL has gene expression profile similar to Ph-positive ALL but without the BCR::ABL1 fusion. The disease presents higher rates of severe clinical features and is associated with unfavorable outcomes. There is still no standard pipeline for molecular characterization of the disease, and no valid predictor gene panel is available worldwide. - Source: PubMed
Publication date: 2024/10/02
Thangrua NonthayaSiriboonpiputtana TeerapongRerkamnuaychoke BudsabaChareonsirisuthigul TakolKorkiatsakul VeerawatPongphitcha PongpakMukda EkcholChutipongtanate SomchaiPakakasama Samart - Stroke is a leading cause of death worldwide, yet current therapeutic strategies remain limited. Among the neuropathological events underlying this disease are multiple cell death signaling cascades, including autophagy. Recent interest has focused on developing agents that target molecules involved in autophagy to modulate this process under pathological conditions. This study aimed to analyze the role of autophagy in cell death induced by an in vitro ischemia-reperfusion (IR) model and to determine whether nitrones, known for their neuroprotective and antioxidant effects, could modulate this process. We focused on key proteins involved in different phases of autophagy: HIF-1α, BNIP3, and BECN1 for induction and nucleation, LC3 for elongation, and p62 for degradation. Our findings confirmed that the IR model promotes autophagy, initially via HIF-1α activation. Additionally, the neuroprotective effect of three of the selected synthetic nitrones (quinolylnitrones and , and homo-bis-nitrone ) partially derives from their antiautophagic properties, demonstrated by a downregulation of the expression of molecular markers involved in various phases of autophagy. In contrast, the neuroprotective power of cholesteronitrone seems to derive from its promoting effects on the initial phases of autophagy, which could potentially help inhibit other forms of cell death. These results underscore the importance of autophagy modulation in neuroprotection, highlighting the potential of inhibiting prodeath autophagy and promoting prosurvival autophagy as promising therapeutic approaches in treating ischemic stroke clinically. - Source: PubMed
Publication date: 2024/08/03
Izquierdo-Bermejo SaraChamorro BeatrizMartín-de-Saavedra María DoloresLobete MiguelLópez-Muñoz FranciscoMarco-Contelles JoséOset-Gasque María Jesús - Echovirus 11 (E11) has gained attention owing to its association with severe neonatal infections. From 2018 to 2023, a surge in severe neonatal cases and fatalities linked to a novel variant of genotype D5 was documented in China, France, and Italy. However, the prevention and control of E11 variants have been hampered by limited background data on the virus circulation and genetic variance. Therefore, the present study investigated the circulating dynamics of E11 and the genetic variation and molecular evolution of genotype D5 through the collection of strains from the national acute flaccid paralysis (AFP) and hand, foot, and mouth disease (HFMD) surveillance system in China during 2000-2022 and genetic sequences published in the GenBank database. The results of this study revealed a prevalent dynamic of E11 circulation, with D5 being the predominant genotype worldwide. Further phylogenetic analysis of genotype D5 indicated that it could be subdivided into three important geographic clusters (D5-CHN1: 2014-2019, D5-CHN2: 2016-2022, and D5-EUR: 2022-2023). Additionally, variant-specific (144) amino acid mutation sites and positive-selection pressure sites (132, 262) were identified in the region. Cluster-specific recombination patterns were also identified, with CVB5, E6, and CVB4 as the major recombinant viruses. These findings provide a preliminary landscape of E11 circulation worldwide and basic scientific data for further study of the pathogenicity of E11 variants. - Source: PubMed
Publication date: 2024/06/05
Ying LiuQiang SunJinbo XiaoBinzhi RenHua ZhaoYong ShiShuaifeng ZhouMei HongKangping ZhouJianping CunYunting ZengJianhua ChenQiong GeYu JuHuanhuan LuJichen LiRuyi CongTingting YangRui WangYanjun ZongTiantian SunLiheng YuXiaoyi WangShuangli ZhuDongmei YanTianjiao JiQian YangZhen ZhuYong Zhang - Sugarcane (Saccharum spp.) is an important sugar and biofuel crop in the world. It is frequently subjected to drought stress, thus causing considerable economic losses. Transgenic technology is an effective breeding approach to improve sugarcane tolerance to drought using drought-inducible promoter(s) to activate drought-resistance gene(s). In this study, six different promoters were cloned from sugarcane bacilliform virus (SCBV) genotypes exhibiting high genetic diversity. In β-glucuronidase (GUS) assays, expression of one of these promoters (P) is similar to the one driven by the CaMV 35S promoter and >90% higher compared to the other cloned promoters and Ubi1. Three SCBV promoters (P, P, and P) function as drought-induced promoters in transgenic Arabidopsis plants. In Arabidopsis, GUS activity driven by promoter P is also upregulated by abscisic acid (ABA) and is 2.2-5.5-fold higher when compared to the same activity of two plant native promoters (P from sugarcane and P from Arabidopsis). Mutation analysis revealed that a putative promoter region 1 (PPR1) and two ABA response elements (ABREs) are required in promoter P to confer drought stress response and ABA induction. Yeast one-hybrid and electrophoretic mobility shift assays uncovered that transcription factors ScbZIP72 from sugarcane and AREB1 from Arabidopsis bind with two ABREs of promoter P. After ABA treatment or drought stress, the expression levels of endogenous ScbZIP72 and heterologous GUS are significantly increased in P:GUS transgenic sugarcane plants. Consequently, promoter P is a possible alternative promoter for genetic engineering of drought-resistant transgenic crops such as sugarcane. - Source: PubMed
Publication date: 2024/03/26
Sun Sheng-RenWu Xiao-BinChen Jian-ShengHuang Mei-TingFu Hua-YingWang Qin-NanRott PhilippeGao San-Ji