Ask about this productRelated genes to: KLHL15 antibody
- Gene:
- KLHL15 NIH gene
- Name:
- kelch like family member 15
- Previous symbol:
- -
- Synonyms:
- KIAA1677
- Chromosome:
- Xp22.11
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-14
- Date modifiied:
- 2018-11-16
Related products to: KLHL15 antibody
Related articles to: KLHL15 antibody
- To utilize the Traditional Chinese Medicine constitution (TCMC) as a complementary and alternative approach for early disease detection and treatment, with a focus on and deficiency constitutions, which serve as key references for disease prevention and management. - Source: PubMed
Xi LongZixuan W UYunfeng Y UJie LinQinghua Peng - Transcription cofactor vestigial-like 3 (VGLL3), as a master regulator of female-biased autoimmunity, also functions in tumor development, while the underlying mechanisms remain largely elusive. Here, we report that VGLL3 plays an important role in DNA damage response (DDR). VGLL3 can be recruited to damage sites in a PARylation-dependent manner. VGLL3 depletion impairs the accumulation of RNF8 and RAD51 at sites of DNA damage, leading to reduced homologous recombination efficiency and increased cellular sensitivity to chemotherapeutic drugs. Mechanistically, VGLL3 can prevent CtIP from KLHL15-mediated ubiquitination and degradation through competitive binding with KLHL15 and, meanwhile, stabilize MDC1 by limiting TRIP12-MDC1 but promoting USP7-MDC1 associations for optimal RNF8 signaling initiation. Consistently, VGLL3 depletion delays tumor development and sensitizes the xenografts to etoposide treatment. Overall, our results reveal an unexpected role of VGLL3 in DDR, which is distinct from its transcriptional cofactor function and not conserved among VGLL family members. - Source: PubMed
Publication date: 2024/10/09
Wu WeiFan ZhenzhenFu HuiMa XiaoluWang DongzhouLiu HongmeiZhang ChuanchaoZheng HuiYang YeranWu HonglinMiao XiuxiuAn RuiyuanGong YifeiTang Tie-ShanGuo Caixia - To analyze the clinical features and genetic etiology of 17 Chinese pedigrees affected with X-linked intellectual disability (XLID). - Source: PubMed
Li YanQin LitaoYang KeChen XinZhu HongjieMi LuyaWang YaopingMa XinruiLiao Shixiu - Specificity within the ubiquitin-proteasome system is primarily achieved through E3 ubiquitin ligases, but for many E3s their substrates-and in particular the molecular features (degrons) that they recognize-remain largely unknown. Current approaches for assigning E3s to their cognate substrates are tedious and low throughput. Here we developed a multiplex CRISPR screening platform to assign E3 ligases to their cognate substrates at scale. A proof-of-principle multiplex screen successfully performed ~100 CRISPR screens in a single experiment, refining known C-degron pathways and identifying an additional pathway through which Cul2 targets C-terminal proline. Further, by identifying substrates for Cul1, Cul2, Cul3, Cul3, Cul3 and Cul3, we demonstrate that the approach is compatible with pools of full-length protein substrates of varying stabilities and, when combined with site-saturation mutagenesis, can assign E3 ligases to their cognate degron motifs. Thus, multiplex CRISPR screening will accelerate our understanding of how specificity is achieved within the ubiquitin-proteasome system. - Source: PubMed
Publication date: 2023/09/21
Timms Richard TMena Elijah LLeng YumeiLi Mamie ZTchasovnikarova Iva AKoren ItayElledge Stephen J - Kelch-like (KLHL) 15, localized on chromosome Xp22.11, was recently identified as an X-linked intellectual disability gene. Herein, we report a case of a male patient with a novel nonsense variant, c.736 C > T p.(Arg246*), in KLHL15, who presented with impaired intelligence, short stature, frequent hypoglycemia, and periodic fever. Patients with nonsense variants in KLHL15 may develop intellectual disabilities, minor skeletal anomalies, and facial dysmorphisms. - Source: PubMed
Publication date: 2023/07/14
Kido JunEgami KimiyasuMisumi YoheiSugawara KeishinTsuchida NaomiMatsumoto NaomichiUeda MitsuharuNakamura Kimitoshi