Ask about this productRelated genes to: HERC4 antibody
- Gene:
- HERC4 NIH gene
- Name:
- HECT and RLD domain containing E3 ubiquitin protein ligase 4
- Previous symbol:
- -
- Synonyms:
- DKFZP564G092, KIAA1593
- Chromosome:
- 10q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-27
- Date modifiied:
- 2015-09-01
Related products to: HERC4 antibody
Related articles to: HERC4 antibody
- SARM1 is a neuronal Nicotinamide adenine dinucleotide (NAD) hydrolase that drives axonal degeneration and neuronal death by depleting NAD, yet how NAD loss triggers axon loss and cell death has remained unclear. Here, we define a nonapoptotic death program downstream of endogenous SARM1 activation and NAD loss using a genetically tractable nonneuronal eHAP cell model. Upon NAD depletion, BAX is activated but caspase activation is suppressed due to APAF1 degradation via the E3 ligase HERC4, effectively uncoupling mitochondrial outer membrane permeabilization from apoptosome formation. Mechanistically, NAD depletion inhibits mTOR/AKT signaling, destabilizing MCL1 and relieving BAX from repression. We further identified Neurofibromatosis type II, NF2, as a regulator that promotes SARM1 transcription through the Hippo-YAP/TAZ pathway. The SARM1-dependent BAX activation and the role of NF2 in axon degradation were validated in neuronal models of axon degeneration. Together, these findings reveal how SARM1-driven metabolic collapse rewires cell death execution, positioning BAX, MCL1, APAF1, NF2, and HERC4 as core effectors in a nonapoptotic degenerative pathway linking metabolic stress to neurodegeneration. - Source: PubMed
Publication date: 2025/12/09
Pan WeilongGuo DejiaLiu DaiyuanWang Xiaodong - The epidermal growth factor receptor (EGFR) and Yes-associated protein (YAP) signalling pathways are two intrinsic mechanisms that typically control fibrosis. The intracellular molecules that regulate these two pathways remain unclear. Here, we investigated how EGFR and YAP signalling control retinal Müller cell-related diabetic retinal fibrosis in vivo and in vitro. - Source: PubMed
Publication date: 2025/11/19
Zhang WeiZhang XiaopeiChen KexiWang Ying - Metastasis is a major cause of treatment failure and poor prognosis in lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) plays a crucial role in promoting LUAD metastasis. Pulmonary sarcomatoid carcinoma (PSC), a highly aggressive non-small cell lung cancer subtype, contains both carcinomatous component (CaC) and sarcomatous component (SaC) with strong metastatic potential. Previous studies have shown that EMT contributes to the formation of Sac in PSC. - Source: PubMed
Publication date: 2025/11/04
Sun Hao-JiaPeng Ming-HuiFeng Zi-YangFu HuaLiu Xue-Wen - Vitiligo is a chronic autoimmune disorder characterized by melanocyte loss and depigmented skin patches. Effective treatment options are limited, and therapeutic progress has been hindered by incomplete understanding of its precise pathogenic mechanisms. We aimed to identify candidate protein biomarkers and therapeutic targets for vitiligo by integrating large-scale proteomics and genomic data using Mendelian randomization (MR). - Source: PubMed
Liu LinliDeng LingliPan XingyuChen JinYu Chunshui - Ewe longevity indicators are complex traits that are lowly heritable, expressed late in life, and sex-limited, making them challenging to include in breeding programs. In this context, genome-wide association studies (GWASs) can provide more information on the complex genetic control of these traits. Therefore, the primary objective of this study was to carry out association analyses for 8 longevity-related traits in 12,734 Katahdin ewes. A total of 126 associations at the chromosome-wide level and 3 at genome-wide level were found. These associations involved 86 single-nucleotide polymorphisms (SNPs) located across 22 chromosomes, with 24 of these SNPs associated with two or more traits. The variants overlapped with genes previously associated with prolificacy (, , , , and ), ovarian follicle pool (, , and ), synthesis and release of reproductive hormones (, , and ), and early pregnancy events (, , , , , , , , and ). Moreover, genes related to response to stress or pathological conditions (, , , , , , , , , , , , , and zinc-finger proteins), growth performance (, , , and ), and carcass traits ( and ) were also implicated. Metabolic pathways such as oxytocin signaling and cardiac-related pathways were enriched. These findings suggest that longevity indicators in Katahdin ewes are highly polygenic traits influenced by a combination of voluntary and involuntary culling reasons. Candidate genes and metabolic pathways influencing reproductive performance and health may play a key role in the functional longevity of Katahdin ewes. - Source: PubMed
Publication date: 2025/07/03
Pinto Luis F BLewis Ronald MRocha Artur OFreking Brad AMurphy Tom WWilson Carrie SNilson Sara MBurke Joan MBrito Luiz F