Ask about this productRelated genes to: FBXW11 antibody
- Gene:
- FBXW11 NIH gene
- Name:
- F-box and WD repeat domain containing 11
- Previous symbol:
- FBXW1B
- Synonyms:
- KIAA0696, Fbw1b, BTRCP2, BTRC2, Hos, Fbw11
- Chromosome:
- 5q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-27
- Date modifiied:
- 2015-09-11
Related products to: FBXW11 antibody
Related articles to: FBXW11 antibody
- Macrophages can be polarized to various states in physiologic and pathologic microenvironments. The simplified but widely accepted M1/M2 polarization states play contradictory roles in tumor progression. The ubiquitin-proteasome system (UPS), particularly F-box proteins, has been reported to be involved in immune regulation. However, the role of F-box and WD-40 domain protein 11 (FBXW11) on macrophage remains unclear. Here, the effects of FBXW11 on macrophage polarization and anti-tumor function were investigated. The results showed that FBXW11 promoted macrophage proliferation and induced a mild M1 polarization phenotype in the absence of tumor cells. Furthermore, overexpression of Fbxw11 enhanced the M1 polarization of macrophages in tumor co-culture system. Moreover, overexpression of Fbxw11 also enhanced glucose uptake and increased mitochondrial reactive oxygen species (ROS) levels, while reducing the mitochondrial membrane potential (Δψ) in macrophages in tumor co-culture system. Functionally, Fbxw11 overexpression increased the phagocytosis and killing of A20 lymphoma cells. RNA-sequencing analysis revealed that FBXW11 activated critical innate immune pathways, including JAK-STAT, NF-κB, and Toll-like receptor signaling, and upregulated effector molecules such as IL-6 and type I interferons. Collectively, our results reveal that FBXW11 paly a positive role on macrophage M1 polarization and anti-tumor function, which broaden the knowledge about how UPS modulates innate immunity. - Source: PubMed
Publication date: 2026/04/03
Zhang SiqiLi RuiyunXie WanzhenCui XiaoxiLi YifeiZhao HuidiRen QianWang LinaZheng Guoguang - Goldenhar syndrome (oculo-auriculo-vertebral spectrum, OAVS) is a rare congenital disorder characterized by craniofacial malformations, systemic anomalies, and significant phenotypic variability. Although it is the second most common craniofacial malformation after a cleft palate, the genetic etiology of Goldenhar syndrome remains largely unexplored. This study aimed to identify genetic variants contributing to Goldenhar syndrome in a Lebanese family with three affected individuals, using whole-exome sequencing and complementary genomic approaches. - Source: PubMed
Publication date: 2026/02/28
Bejaoui YosraAl-Sarraj YasserAl-Hage JanaBitar Fadi FEl Hajj NadyNemer GeorgesKurban Mazen - Lysosomal associated membrane protein family member 5 (LAMP5), a recently identified member of the LAMP family, has been associated with poor prognosis in multiple cancer types; however, its precise oncogenic mechanisms remain unclear. This study systematically investigated the oncogenic and immunological functions of LAMP5 using multiple datasets. LAMP5 expression was significantly dysregulated in various cancers, highlighting its potential as a diagnostic and prognostic biomarker. GSVA indicated that LAMP5 expression is likely associated with enhanced cell proliferation and tumor invasive potential; it may also be correlated with alterations in anti-tumor immune responses. Immune infiltration analyses using Multi-database analyses revealed that high LAMP5 expression was associated with increased infiltration of immune cells including natural killer T cells and tumor-associated fibroblasts, accompanied by upregulation of immune checkpoint molecules and chemokines. Validation using various immunotherapy cohorts showed that elevated LAMP5 expression may be linked to reduced immunotherapy efficacy. A focused investigation in bladder cancer revealed that LAMP5 facilitates proliferation via regulation of the FBXW11/p27 axis. These findings identify LAMP5 as a multifunctional oncoprotein with both prognostic and therapeutic relevance in bladder cancer. This study provides insights into the molecular mechanisms by which LAMP5 promotes bladder cancer progression and offers potential targets for therapeutic intervention and clinical management. - Source: PubMed
Publication date: 2026/02/09
Lin ZhenniZhao KunWang SijiaLiu JiantingLiu YijieQiang KemengHuang MingzhiSun NingZhang PeipeiHu YanLu YongyongJin Honglei - Acute pancreatitis (AP) remains a challenging clinical condition with limited therapeutic options and high mortality rates in severe cases. Traditional anti-inflammatory approaches have shown disappointing results in clinical trials, highlighting the urgent need for novel therapeutic strategies targeting the underlying pathophysiological mechanisms. The study by Jia presents compelling evidence for a previously unrecognized mechanism through which rutaecarpine, a bioactive alkaloid from traditional Chinese medicine, exerts protective effects against AP. This research demonstrates that rutaecarpine alleviates AP by targeting the epigenetic machinery, specifically through enhancer of -mediated suppression of . The authors employed both cerulein-induced AR42J cell models and sodium taurocholate-induced rat models to establish the therapeutic efficacy of rutaecarpine and elucidate its molecular mechanisms. Their findings reveal that rutaecarpine upregulates expression, leading to increased histone H3 methylation at the promoter region, thereby suppressing expression and consequently reducing inflammatory infiltration and oxidative stress. The significance of this work extends beyond demonstrating rutaecarpine's protective effects. It identifies as a novel therapeutic target in AP and provides the first evidence that traditional Chinese medicine compounds can modulate epigenetic reprogramming in pancreatic inflammation. Recent studies have confirmed 's role as an inflammatory biomarker in pancreatitis, supporting the clinical relevance of this pathway. The study's comprehensive approach, combining molecular docking, cellular thermal shift assays, and co-immunoprecipitation studies, strengthens the mechanistic insights. These findings open new avenues for AP treatment by targeting epigenetic regulators rather than relying solely on conventional anti-inflammatory strategies, potentially leading to more effective therapeutic interventions for this devastating condition. - Source: PubMed
Liang Li-PingZhang LeJin Dan-DanZhang Shao-HengLiu Le - Regulatory T cells (Tregs) exhibit compromised immunosuppressive functions in psoriasis, yet understanding of their dysregulated perturbations remains limited. - Source: PubMed
Publication date: 2026/01/12
Huang ZhihaoSui YuanLiu Shengxiu