Ask about this productRelated genes to: FBXO25 antibody
- Gene:
- FBXO25 NIH gene
- Name:
- F-box protein 25
- Previous symbol:
- -
- Synonyms:
- FBX25
- Chromosome:
- 8p23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-27
- Date modifiied:
- 2014-11-18
Related products to: FBXO25 antibody
Related articles to: FBXO25 antibody
- F-box proteins serve as substrate adapters in SCF ubiquitin ligase complexes, regulating proteolysis to modulate eukaryotic signaling, such as cell cycle progression and stress responses. Here, we characterize the F-box gene family in water buffalo (Bubalus bubalis), identifying 70 genes across 24 autosomes and the X chromosome using HMMER and BLASTP searches against Pfam domains. Phylogenetic analysis with orthologs from human, sheep, goat, horse, and cattle grouped them into four subfamilies (FBX, FBXL, FBXW, FBXO), with 58 core buffalo genes aligning closely to mammalian clades (bootstrap >95%). MEME analysis identified nine conserved motifs, including the F-box domain (motifs 1-2, e.g., LPDELLLYIFSYLDA), LRRs for specificity (motif 3), and WD40 repeats for scaffolding (motifs 5-7,9), confirmed by Pfam. Gene structures ranged from 2 to 23 exons, indicating regulatory diversity. Synteny with cattle conserved ∼85% of orthologs, reflecting artiodactyl ancestry. Physicochemical properties spanned MW 18.10-93.71 kDa (mean 49.2 kDa, excluding outliers), pI 4.27-10.41, and GRAVY -0.75 to 0.143 (mean - 0.32), consistent with hydrophilic profiles. Five segmental duplications (e.g., FBXO25/FBXO32) showed Ka/Ks ratios of 0.144-1.194 (four <1), suggesting purifying selection and divergence 48-220 MYA (Ks Poisson correction, refined ruminant rate). nsSNP analysis in 70 genes via nine tools predicted >95% benign/synonymous effects, with deleterious exceptions like FBXO16 V160T (consensus score 0.82, disrupting binding) and FBXO48 R7G (0.91, affecting stability). WoLF PSORT localized 17 nuclear, 10 cytoplasmic, 12 plasma membrane, 7 mitochondrial, 5 extracellular, and 7 dual sites, implying roles in transcription, degradation, and trafficking. These genes may represent potential candidates for future functional studies and genome-editing approaches; however, experimental validation will be required before their application in breeding programs. - Source: PubMed
Publication date: 2026/04/04
Nasir TanveerSafdar MuhammadImran SafdarTariq MuhammadJunejo YasmeenOzaslan MehmetYounus Muhammad - Given the high morbidity and mortality of colorectal cancer (CRC), as well as its challenging treatment, the present study was conducted to identify reliable prognostic signatures for predicting clinical outcomes. - Source: PubMed
Publication date: 2026/01/02
Wang QiangChen ZhongshengLi LiangheZhang JiandongLi QingZhan Wei - is a bacterium that causes chlamydia, the most diagnosed bacterial sexually transmitted infection (STI) in the world. In the U.S., chlamydia is most prevalent among non-Hispanic African American (AA) individuals, implying substantial racial disparity. Despite prevention and control efforts, reinfection is common, suggesting that some individuals have insufficient protective immunity to . To better understand the genetically mediated risks of chlamydia reinfection, we sought to identify genetic loci associated with reinfection using a Genome-Wide Association Study (GWAS) approach. - Source: PubMed
Publication date: 2025/09/25
Tiwari Hemant KPatki AmitSrinivasasainagendra VinodhVejandla Sandeep CSadeesh ArchishGupta KanupriyaAppah MaryGeisler William M - Ubiquitination, a pivotal posttranslational modification, plays a central role in regulating many biological processes. Nevertheless, its prognostic significance in cervical cancer remain largely unexplored. - Source: PubMed
Publication date: 2025/06/04
Ding WenxiuLiu ShuZhang HuiaiDing HongxiaZhou ShaobingYe Hongxun - ACTN1 belongs to the α-actinin family and is considered a tumor-promoting gene in various tumor types; however, the biological function and fundamental molecular mechanisms of ACTN1 in ovarian cancer remain unclear. - Source: PubMed
Publication date: 2025/03/20
Sun ZhengweiZhang ZihanZhang JiaminYang ZiyiPan ShuyaLi XiaoshengWang XujingZhu Xueqiong