Ask about this productRelated genes to: TTC6 antibody
- Gene:
- TTC6 NIH gene
- Name:
- tetratricopeptide repeat domain 6
- Previous symbol:
- NCRNA00291, C14orf25
- Synonyms:
- -
- Chromosome:
- 14q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-20
- Date modifiied:
- 2018-11-22
Related products to: TTC6 antibody
Related articles to: TTC6 antibody
- Fatty acid metabolism (FAM) is essential for cancer cell proliferation and progression, contributing to membrane synthesis, energy storage, and signaling molecule production. However, effective therapeutic strategies targeting FAM are yet to be established in clinical practice. This study aimed to develop a novel FAM-related prognostic signature for bladder cancer (BLCA) and investigate its biological and clinical significance. - Source: PubMed
Publication date: 2026/02/27
Yu HuiLei QingqiangYang WenyongCao MinZhang MiaoyuWang TaisongDong JunhaoChen XueruiSu XuHuang YiXu HeZhuo HuiLin Liangbin - NCI-MATCH (EAY131) is a precision medicine trial using genomic testing to allocate patients with advanced malignancies to targeted treatments. Arm Y evaluated capivasertib, a pan AKT inhibitor, in patients with an -mutated tumor. Here, we report on the translational objectives of the study, a molecular and genomic analysis of specimens to identify potential biomarkers of response or resistance to capivasertib. - Source: PubMed
Publication date: 2025/03/28
McCourt Carolyn KGross JacobKalinsky KevinGuan PingMcShane Lisa MWang VictoriaO'Dwyer Peter JLahey Matthew TMaican CaydenBu XiangningPatton DavidHarris Lyndsay N - Obesity is an established risk factor for hypertension, but the mechanisms are only partially understood. We examined whether body mass index (BMI)-related DNA methylation (DNAm) variation would mediate the association of BMI with blood pressure (BP). We first conducted a genomewide DNA methylation analysis in monozygotic twin pairs to detect BMI-related DNAm variation and then evaluated the mediating effect of DNAm on the relationship between BMI and BP levels using the causal inference test (CIT) method and mediation analysis. Ontology enrichment analysis was performed for CpGs using the GREAT tool. A total of 60 twin pairs for BMI and systolic blood pressure (SBP) and 58 twin pairs for BMI and diastolic blood pressure (DBP) were included. BMI was positively associated with SBP (β = 1.86, = .0004). The association between BMI and DNAm of 85 CpGs reached < 1×10 level. Eleven BMI-related differentially methylated regions (DMRs) within , , , , , , , , , and were found. Of the 85 CpGs, 9 mapped to , , , , , and were significantly associated with SBP levels. Of the 9 CpGs, 2 within negatively mediated the association between BMI and SBP, with a mediating effect of -0.24 (95% CI [-0.65, -0.01]). BMI was also positively associated with DBP (β = 0.60, = .0495). The association between BMI and DNAm of 193 CpGs reached < 1×10 level. Twenty-five BMI-related DMRs within , , , , , , and were found. Of the 193 CpGs, 33 mapped to , , , , , , and were significantly associated with DBP levels. Of the 33 CpGs, 12 within , , , , , , and negatively mediated the association between BMI and DBP, with a total mediation effect of -0.66 (95% CI [-1.07, -0.30]). Interestingly, BMI might also negatively mediate the association between the DNAm of most CpG mediators mentioned above and BP. The mediating effect of DNAm was also found when stratified by sex. In conclusion, DNAm variation may partially negatively mediate the association of BMI with BP. Our findings may provide new clues to further elucidate the pathogenesis of obesity to hypertension and identify new diagnostic biomarkers and therapeutic targets for hypertension. - Source: PubMed
Publication date: 2024/01/31
Yao JieNing FengWang WeijingZhang Dongfeng - Sperm motility and structural integrity are essential for successful fertilization in vivo, and any hindrance of the correct assembly of the axoneme and peri-axonemal structures in the sperm flagellum can lead to fertility problems. While there has been considerable advancement in studying diseases related to the flagellum, the underlying mechanisms that control sperm movement are not yet fully understood. In this study, we reveal that the tetratricopeptide repeat protein 6 () gene, expressed mainly in the testes, plays a crucial role in maintaining male fertility in mice. We further demonstrate that the knockout of in mice results in decreased sperm motility and induces an abnormal circular swimming pattern, consequently leading to male subfertility. Morphological analysis showed an atypical hairpin-like appearance of the spermatozoa, and ultrastructural studies showed unsheathed flagella at the juncture between the midpiece and principal piece. Collectively, these findings suggest that TTC6 plays an essential role in maintaining the stability of the annulus region of the sperm flagellum, thus ensuring the swift and directed motion of sperm. - Source: PubMed
Publication date: 2023/08/18
Wang ZiqiFang KailunWan YanlingYin YingyingLi MengjingXu KeLi TongtongCao YongzhiLv YueLu GangLiu HongbinHuang Tao - Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality with infection by human papilloma virus (HPV) being the most important risk factor. We analysed the association between different viral integration signatures, clinical parameters and outcome in pre-treated CCs. - Source: PubMed
Publication date: 2020/11/16
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