Ask about this productRelated genes to: NLRP1 antibody
- Gene:
- NLRP1 NIH gene
- Name:
- NLR family pyrin domain containing 1
- Previous symbol:
- NALP1, SLEV1
- Synonyms:
- KIAA0926, DKFZp586O1822, CARD7, NAC, CLR17.1, DEFCAP, VAMAS1
- Chromosome:
- 17p13
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-28
- Date modifiied:
- 2016-06-01
Related products to: NLRP1 antibody
Related articles to: NLRP1 antibody
- Voltage-gated sodium channel (VGSC) dysregulation, particularly of the Nav1.6 subtype, is a core mechanism underlying epileptogenesis and its associated neuropsychiatric comorbidities. The scorpion venom peptide BmK AS has demonstrated anticonvulsant potential, but its efficacy in chronic epilepsy and the precise mechanisms of action remain undefined. - Source: PubMed
Publication date: 2026/04/15
Zhao LuWang ChaoQi DandanSun MengQi HongDong YinZeng YunqingTang LeleDing JieZhu YudanXiao QianWu WeiJi YonghuaTao Jie - Upon stimulation, NLRP1 assembles into an inflammasome complex to defend against pathogen invasion and protect the host. However, excessive activation of NLRP1 can disrupt immune homeostasis and contribute to various inflammatory diseases. Therefore, understanding the regulatory mechanisms of the NLRP1 inflammasome is of significant importance. The B-cell lymphoma-2 (BCL-2) protein family, known as key regulators of mitochondrial outer membrane permeability, plays a central role in the mitochondrial-mediated apoptosis pathway. In the present study, we cloned the anti-apoptotic protein CcBCL-2-like sequence from the genome of common carp and discovered that it could interact with NLRP1 and participate in the regulation of pyroptosis. The qPCR analysis showed that CcBCL-2-like was highly expressed in the brain and intestinal tissues of healthy common carp (n = 3), and the expression of CcBCL-2-like in intestinal tissue was significantly upregulated following stimulation with A. hydrophila and E. tarda. Immunofluorescence assays indicated that CcBCL-2-like localized both in the nucleus and cytoplasm. Furthermore, co-immunoprecipitation and co-localization experiments demonstrated a direct interaction between CcBCL-2-like and CcNLRP1 in 293T and EPC cells. Functional analysis of inflammasome downstream pathways revealed that CcBCL-2-like significantly inhibited ASC oligomerization, caspase-1 enzymatic activity, LDH release, and pyroptosis triggered by the CcNLRP1 inflammasome. These findings provide a theoretical foundation for further elucidating the activation mechanism of CcNLRP1 and for developing strategies to prevent and treat infectious diseases in fish. - Source: PubMed
Publication date: 2026/04/27
Chen QiChen XinpingZhang JiahuiYang GuiwenLi WeiLi Hua - Altered glial function, and increased proinflammatory cytokines are associated with behavioral and cognitive problems seen in autism spectrum disorder (ASD). In this study, we aimed to investigate the neuroinflammatory process in ASD and the relationship between neuroinflammatory markers and the severity of autism symptoms. - Source: PubMed
Kara BülentSavaş MerveÖzer TolgahanŞişmanlar Şahika GülenAkarsu RemziyeÖztürk Sinem YavuzAkpinar Şeyma NurDeniz AdnanGüneş Ayfer SakaryaDursun FulyaAkkoyunlu Deniz SünnetçiÇine NaciTüzün Erdem - The genetics of multiple sclerosis (MS) has advanced dramatically through the combined impact of high-throughput genotyping, large biobank resources, worldwide collaborations, and powerful computational analyses. Over the past two decades, genome-wide association studies (GWAS) have significantly reshaped our understanding of the genetic architecture of complex multifactorial diseases such as MS. The number of MS susceptibility-associated genomic regions is now more than 200, underscoring its highly polygenic nature. Within the major histocompatibility complex (MHC), the HLA-DRB1*15:01 allele and its extended haplotypes remain the most robust and reproducible risk factors. This historical association reflects a long-standing link between antigen presentation, immune regulation, and central nervous system autoimmunity. Beyond the MHC, common non-HLA loci implicate a wide network of immune pathways involving T-cell and B-cell activation, cytokine signaling, and antigen presentation. Moreover, rare variant analyses and family-based designs, although limited in power, have uncovered additional susceptibility genes, such as PRF1, CYP27B1, and NLRP1, shedding light on distinct mechanisms of immune modulation and metabolic regulation. The step forward will be now to explore diverse genetic ancestry populations, bearing differences in risk allele frequencies; multi-ethnic and family-based designs are needed to disentangle true genetic effects from environmental confounders. In parallel, progress has been made toward MS progression, as variants potentially influencing disability accumulation and neurodegeneration were identified. These findings have deepened our understanding of MS pathophysiology. They now provide a foundation for future integrative models that combine genetics, environment, and multi-omics data to elucidate disease heterogeneity and guide personalized therapeutic strategies. - Source: PubMed
Publication date: 2026/04/02
Bourguiba-Hachemi SParis JGourraud P-AVince N - This study investigated the clinical significance of pyroptosis-related factors, including NLRP1, NLRP3, and HMGB1, in patients with acute coronary syndrome (ACS), and analyzed their prognostic value. - Source: PubMed
Publication date: 2026/03/02
Shi PeiZheng Qiangsun