Ask about this productRelated genes to: RHPN1 antibody
- Gene:
- RHPN1 NIH gene
- Name:
- rhophilin Rho GTPase binding protein 1
- Previous symbol:
- -
- Synonyms:
- KIAA1929, RHPN, ODF5
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-21
- Date modifiied:
- 2016-12-08
Related products to: RHPN1 antibody
Related articles to: RHPN1 antibody
- The sensitivity of nasopharyngeal carcinoma (NPC) cells to radiation is the primary factor influencing the therapeutic effect of radiotherapy for patients with NPC. This study aimed to investigate the mechanism underlying the potential regulatory effect of long non-coding RNA (lncRNA) on the radiosensitivity of NPC cells. - Source: PubMed
Publication date: 2026/01/27
Jiang JunWang DongKang MeiQian YaqinZha TianqiShao Chang-Sheng - Idiopathic pulmonary fibrosis (IPF) is associated with poor prognosis. - Source: PubMed
Publication date: 2026/01/06
Yang WangPan Peng - BACKGROUND: Several long non-coding RNAs (lncRNAs) have been identified as oncogenic factors in hepatocellular carcinoma (HCC). This study aims to investigate the biological function and prognostic value of lncRNA RHPN1-AS1 in HCC. METHODS: HCC data were drawn from TCGA database. Coexpression, enrichment, and immune infiltration analyses were performed to identify the roles and mechanisms of RHPN1-AS1 in HCC. Kaplan‒Meier analysis was used to determine overall survival (OS) and progression-free survival (PFS). Univariate and multivariate Cox regression analyses were employed to discover independent prognostic indicators. A prognostic nomogram was established and validated. RESULTS: The expression of RHPN1-AS1 was significantly upregulated in HCC samples, and was associated with poor OS and PFS. Univariate Cox regression analysis demonstrated that RHPN1-AS1, AJCC stage, T stage, and M stage were correlated with OS. In multivariate Cox regression analysis, RHPN1-AS was significantly linked to HCC prognosis. The predictive model based on RHPN1-AS1 and clinical factors reached good accuracy. In addition, RHPN1-AS1 was positively co-expressed with TONSL, CHRAC1, JRK, RECQL4, STK3, and CYHR1. Functional enrichment analysis of RHPN1-AS1 co-expressed genes were indicated significant involvement in the cell cycle, DNA replication, and double-strand break repair. CONCLUSIONS: LncRNA RHPN1-AS1 was identified as a potential independent prognostic indicator for HCC patients. A prognostic nomogram integrating RHPN1-AS1 expression and T and M stage was constructed to predict the survival of HCC patients. Furthermore, our findings suggested the involvement of the cell cycle in the action of RHPN1-AS1, providing new insights into the molecular mechanism underlying HCC progression. - Source: PubMed
Publication date: 2025/12/23
Li XiaoxuanLi YujingLuan XinchiLeng ChuanyuLi XinSun XueyingTian JingwenSong JialinGuo JingQiu Wensheng - Prostate cancer has a high incidence and a low 5-year survival rate. We aimed to combine cholesterol- and immune-related genes to screen prostate cancer prognosis-related genes and construct a prognostic risk model. - Source: PubMed
Publication date: 2025/09/26
Wu Jie - Distant metastasis is a primary factor contributing to the significantly shorter survival time of patients with advanced lung adenocarcinoma. The transcription factor Kruppel-like factor 5 (KLF5) facilitates the progression of lung adenocarcinoma. However, the specific mechanism by which KLF5 is involved in the tumor metastasis of lung adenocarcinoma metastasis remains largely unclear. - Source: PubMed
Publication date: 2025/10/10
Zhang TaoWang Ruo-QiYang Yu-BinZhao Wen-JunZhang Qi-DongMa Xu-LiGuo Juan-JuanSu QianShen Xiao-YunLu Yong-BinSu FeiHou Xiao-Ming